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1.
Georgian Med News ; (336): 37-44, 2023 Mar.
Article in English | MEDLINE | ID: mdl-37166877

ABSTRACT

The aim of the research is to study the microstructure, antibiotic-absorbing and framework capacity of the fibrous non-woven PCL matrices designed by us for the regeneration of tissues and capillaries. Samples of microfibrous non-woven matrices made by our technology out of polycaprolactone PCL (invention patent of Ukraine № 119958) were used in the work. Antibiotic retention in samples of matrix materials was evaluated during the 1st, 3rd, 5th, 7th, 14th, 18th and 21st days of the experiment. The experimental part of the research was performed using 30 laboratory animals (rabbits). On the basis of microscopic studies of the biopolymer microfiber matrices obtained by us, the relationship between the increase in polymer concentration in the sucrose melt and the increase in the percentage of thicker microfibers was determined. Microbiological analysis of the antibiotic-absorbing capacity of the obtained microfibrous biopolymer non-woven matrices determined that lincomycin impregnated into polymer matrices is characterized by less stability during storage than cefazolin. Antibiotic concentrations of the impregnated matrix material samples were actively maintained at the level of control values for a period of 5 days. The pathomorphological analysis of soft tissues at all times of subcutaneous implantation in the experiment made it possible to determine the fact of regeneration of tissues and the microcirculatory channel through the entire thickness of the fibrous matrix. This was confirmed by a significant decrease in the area of the connective tissue matrix per vessel from (49345.18+485.63) µm2 to (24797.47+480.28) µm2, an increase in the cross-sectional area of vessels from (697.61+21.79) µm2 to (1321.23+24.82) µm2 and a decrease in the thickness of vascular walls from (3.2+0.05) µm to (2.65+0.07) µm (p<0.01) from the periphery to the center of the frame. These facts, in our opinion, confirm the framework function of the polymer matrix synthesized by us, which is also a means of one-time local delivery of the medicine to the tissues in the damaged area.


Subject(s)
Tissue Engineering , Tissue Scaffolds , Animals , Rabbits , Tissue Scaffolds/chemistry , Microcirculation , Polymers/chemistry , Biopolymers , Anti-Bacterial Agents/pharmacology
2.
Georgian Med News ; (291): 45-49, 2019 Jun.
Article in English | MEDLINE | ID: mdl-31418729

ABSTRACT

The objective of the research consisted in the evaluation of the possibility and effectiveness of fibre matrix use in order to maintain the original geometric parameters of the osseous crest in the places of alveolar sockets of the extracted teeth. Patients in the study group underwent filling of a post-extraction alveolar socket by fibre matrix, developed by the authors of the article, with further overlapping with a polymeric membrane (KLS Martin), which was modified in each certain case according to the peculiarities of defect configuration by means of thermoactive pressing method (Patent for invention of Ukraine №114143). Filling or overlapping of the post-extraction alveolar sockets were not performed in patients of the control group. Computed tomography in patients under research was made 4 months after the initial surgical intervention. Analysis of the parameters of the osseous tissue in the places of the alveolar sockets of the removed teeth was conducted 4 months after the extraction on the basis of the cone-beam computed tomography (CBCT) results in the ImageJ software (Wayne Rasband (NIH)) using the specialized BoneJ plugin. In the study group, the average level of resorption of the medial bone wall of the post-extraction socket was 0.6±0.4 mm (range of indices - 0.3-0.8 mm), distal bone wall - 0.4±0.3 mm (range of indices - 0.2-0.6 mm), vestibular bone wall - 1.4±0.7 mm (range of indices - 0.9-2.0 mm), lingual bone wall - 1.2±0.7 mm (range of indices - 0.8-1.9 mm). In the control group, the average level of bone resorption reached 1.4±0.5 mm (range of indices - 0.8-1.7 mm) from the medial side, 0.9±0.6 mm (range of indices - 0.7-1.5 mm) from the distal side, 2.2±0.4 mm (range of indices - 1.5-2.6 mm) from the vestibular side, 2.1±0.6 mm (range of indices - 1.3-2.4 mm) from the oral side. Obtained results indicate a more pronounced effect of an alveolar socket preservation when using fibre matrix compared with the ordinary healing of the tooth extraction region, which was confirmed by the results of the CBCT examination. Therefore, this approach can be recommended for introduction into practice to optimize the conditions for delayed implantation in the area of the teeth removed due to endodontic, periodontal, traumatic lesions or extensive caries pathology with the pronounced inflammatory changes at the time of intervention.


Subject(s)
Alveolar Bone Loss/prevention & control , Alveolar Ridge Augmentation/methods , Tooth Extraction , Tooth Socket/surgery , Humans , Ukraine
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