1.
Bioorg Med Chem Lett
; 26(2): 272-276, 2016 Jan 15.
Article
in English
| MEDLINE
| ID: mdl-26707395
ABSTRACT
A novel series of substituted quinazoline derivatives were designed, synthesized and evaluated for their hypolipidemic activity in cholesterol induced hyperlipidemic rats. In vivo screening concluded that compounds A-4, C-5 and C-6 have shown potent antihyperlipidemic activity by decreasing the plasma level of triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL), followed by increase in level of high density lipoprotein (HDL).