ABSTRACT
INTRODUCTION: Infections caused by Acinetobacter junii are rarely reported. However, some outbreaks of septicemia in neonates and pediatric oncology patients, as well as meningitis, peritonitis, and ocular infection have been described. Since it is highly infrequent to find the molecular characterization of A. junii strains in literature, in this study we described the molecular characterization of A. junii isolates recovered from blood samples of a renal transplant patient. METHODOLOGY: The case was defined as a catheter-related bacteremia caused by A. junii. The patient responded favorably after catheter removal and treatment with ciprofloxacin. RESULTS AND CONCLUSION: The complete molecular characterization of the isolate showed that it harbored a class 1 integron and diverse DNA mobile elements. This explains its genomic plasticity for acquiring antimicrobial resistance determinants and for adapting to a nosocomial niche.
Subject(s)
Acinetobacter Infections/microbiology , Acinetobacter/genetics , Bacteremia/microbiology , DNA, Bacterial/genetics , Integrons , Interspersed Repetitive Sequences , Acinetobacter/isolation & purification , Acinetobacter Infections/drug therapy , Adult , Anti-Bacterial Agents/therapeutic use , Bacteremia/drug therapy , Catheter-Related Infections/drug therapy , Catheter-Related Infections/microbiology , Ciprofloxacin/therapeutic use , Female , Humans , Kidney Transplantation , Transplant Recipients , Treatment OutcomeABSTRACT
Acinetobacter baumannii pigmented strains are not common in clinical settings. Here, we report an outbreak caused by indigo-pigmented A. baumannii strains isolated in an acute care hospital in Argentina from March to September 2012. Pan-PCR assays exposed a unique pattern belonging to the recently described regional CC113(B)/CC79(P) clonal complex that confirms the relevant relationships among the indigo-pigmented A. baumannii strains. All of them were extensively drug resistant and harbored different genetic elements associated with horizontal genetic transfer, such as the transposon Tn2006, class 2 integrons, AbaR-type islands, IS125, IS26, strA, strB, florR, and the small recombinase ISCR2 associated with the sul2 gene preceded by ISAba1.
Subject(s)
Acinetobacter Infections/epidemiology , Acinetobacter Infections/microbiology , Acinetobacter baumannii/drug effects , Acinetobacter baumannii/metabolism , Disease Outbreaks , Drug Resistance, Multiple, Bacterial , Pigments, Biological/metabolism , Acinetobacter baumannii/isolation & purification , Adult , Aged , Aged, 80 and over , Animals , Argentina , Cluster Analysis , DNA, Bacterial/chemistry , DNA, Bacterial/genetics , Female , Genotype , Humans , Interspersed Repetitive Sequences , Male , Middle Aged , Molecular Sequence Data , Molecular Typing , Polymerase Chain Reaction , Sequence Analysis, DNASubject(s)
Aortic Valve/microbiology , Endocarditis, Bacterial/microbiology , Neisseria mucosa/isolation & purification , Neisseriaceae Infections/microbiology , Adult , Alcoholism/complications , Anti-Bacterial Agents/therapeutic use , Aortic Valve/abnormalities , Aortic Valve Stenosis/complications , Cardiomyopathy, Dilated/complications , Disease Susceptibility , Drug Resistance, Multiple, Bacterial , Drug Therapy, Combination , Endocarditis, Bacterial/drug therapy , Endocarditis, Bacterial/etiology , Heart Valve Diseases/complications , Humans , Male , Neisseria mucosa/drug effects , Neisseriaceae Infections/drug therapy , Neisseriaceae Infections/etiology , Smoking/adverse effectsABSTRACT
No disponible
