Rango de acción del colocador como indicador de rendimiento en voleibol masculino / Setter’s Action Range as A Performance Indicator in Male Volleyball

Este estudio buscó comprobar si la zona ideal de colocación es la más usada, comparar dicha zona con la Posición Media (AP) del colocador con disponibilidad de primer tiempo y verificar si la distancia entre ambas puede considerarse un indicador de rendimiento. Analizamos 2291 acciones de los 12 mejores equipos del mundial masculino de voleibol (2010). Registramos la posición (latitud y profundidad) del colocador. Calculamos su AP y la distancia a la zona ideal. Recogimos la eficacia de recepción desde las estadísticas de la FIVB. Una correlación aportó la Rho de Spearman. Los resultados confirman el área de latitud 6 y profundidad 1 como la más exitosa, pero los equipos pueden contar con primer tiempo cuando el colocador sale de ella. La distancia entre la AP con disponibilidad de primer tiempo y la zona ideal de colocación correlaciona con la clasificación final más que la eficacia de recepción (AU)

This study aimed to check if the ideal setting zone is the most frequently used, to compare this zone with the Average Position of the setter with middle blocker availability (AP) and to verify if the distance between both can be considered a performance indicator. 2291 actions of the top-12 teams in the 2010 Men’s Volleyball World Championship were analysed. The position (latitude and depth) of the setter was registered. The AP and the distance with the ideal setting zone were calculated. The reception efficacy was retrieved from the FIVB. Spearman’s Rho was obtained through a correlation. Results confirm the area of latitude 6 and depth 1 as the most successful. Nevertheless, teams are able to maintain first tempo availability despite moving the setter out of it. The distance between the AP and the ideal setting zone correlates to the final ranking more than the reception efficacy. (AU)

Nasogastric enteral feeding tubes modulate preterm colonization in early life.

BACKGROUND: Preterm infants are generally fed through nasogastric enteral feeding tubes (NEFTs). The aim of this work was to evaluate the role of NEFTs in the initial colonization of the preterm gut and its evolution within the first 2 weeks after birth. METHODS: For this purpose, fecal and NEFT-derived samples from 30 preterm infants hospitalized in a neonatal intensive care unit (NICU) were collected from birth to the second week of life. Samples were cultivated in ten culture media, including three for the isolation of antibiotic-resistant microorganisms. RESULTS: Isolates (561) were identified by 16S ribosomal RNA gene sequencing. Although the first NEFTs inserted into the neonates after birth were rarely colonized, analysis of NEFTs and fecal samples over time revealed a significant increase in bacterial abundance, diversity, and detection frequency. Results showed a parallel colonization between time-matched NEFTs and fecal samples, suggesting an ongoing bidirectional transfer of bacteria from the neonatal gut to the NEFTs and vice versa. CONCLUSIONS: In short-term hospitalization, length is by far the determinant factor for the early colonization of preterm infants. As NEFT populations reflect the bacterial populations that are colonizing the preterm in a precise moment, their knowledge could be useful to prevent the dissemination of antibiotic-resistant strains. IMPACT: The hospital environment modulates preterm colonization immediately after birth. The colonization of preterm feces and NEFTs occurs in parallel. There is an ongoing bidirectional transfer of microorganisms from the neonatal gut to the NEFTs and vice versa. Bacterial communities inside NEFTs could act as reservoirs of antibiotic resistance genes. NEFT populations reflect the bacteria that are colonizing the preterm at a precise moment.

Episodio maníaco tras la administración simultánea de 4 vacunas: relación temporal frente a relación causal. A propósito de un caso / Manic episode after the simultaneous administration of 4 vaccines: temporal relationship versus causal relationship. A case report

Ante un cambio radical en el comportamiento en un varón de 17 años, a las 12 horas de administrar, en el mismo día, las vacunas contra el Meningococo C, Hepatitis B, Triple Vírica y Varicela, y la detección de un cuadro maníaco a la semana, se sospechó que se tratase de un cuadro de encefalitis post-vacunal. A pesar de la ausencia de hallazgos patológicos en las exploraciones complementarias realizadas, y aunque en la literatura científica no se haya demostrado una asociación temporal a día de hoy, no podemos aceptar ni descartar con certeza la sospecha diagnóstica dado que no contamos con la serología infecciosa o un estudio de anticuerpos en líquido cefalorraquídeo. Los efectos secundarios graves tras vacunaciones no han quedado claramente demostrados, lo que sí está ampliamente demostrado es que la inmunidad adquirida es uno de los mayores logros de la medicina que ha ayudado a erradicar enfermedades potencialmente mortales

A radical behavioral change was observed in a 17-year-old male 12 hours after having received vaccines for Meningococcus C, Hepatitis B, Triple Viral and Varicella on the same day. Moreover a manic episode was detected one week later. It was suspected that this was a case of post-vaccinal encephalitis. In spite of the absence of pathological findings in the complementary explorations carried out and although a temporal association has not been demonstrated to date in the scientific literature, we can not be certain of this diagnostic suspicion since we do not have the infectious serology or a study of antibodies in central spinal fluid. Serious side effects after vaccinations have never been clearly demonstrated, while it has been widely demonstrated that the acquired immunity from these vaccines is one of the greatest achievements of medicine, and this has helped to eradicate life-threatening diseases

Validation of the AIDS Prevention Questionnaire: A Brief Self-Report Instrument to Assess Risk of HIV Infection and Guide Behavioral Change.

This paper describes the process of building and validating the AIDS Prevention Questionnaire (CPS), a brief HIV risk assessment measure. An initial 64-items bank was filled out by 466 young people (192 men and 274 women), aged between 17 and 26 years (M = 20.62; SD = 2.15). The exploratory factor analysis revealed five components: Knowledge about HIV, Condom Attitudes, Intentions of Condom Use, Safe sexual behavior and Stigma and discrimination towards people living with HIV. This structure was confirmed by confirmatory factor analysis. The internal consistency for the different components ranged from .67 to .74. Moreover, CPS has a classification system that allows determining the level of risk. These results support the AIDS Prevention Questionnaire as a valid and reliable measure to detect earlier the risk for HIV infection and to design adjusted preventive interventions.

Toracotomía urgente en traumatismos penetrantes y cerrados: incidencia, características demográficas y análisis de resultados en un registro hospitalario de traumatizados graves / Urgent thoracotomy in blunt and penetrating trauma: incidence, demographic characteristics and analysis of results in a hospital registry of severe trauma

Objetivo. En países de nuestro entorno europeo la necesidad de toracotomía urgente por traumatismo es escasa. Nuestro objetivo ha sido analizar la gravedad de los pacientes con traumatismo penetrante (TP) y cerrado (TC) que han necesitado toracotomía urgente, con el fin de valorar si la toracotomía por traumatismo en nuestro medio no conlleva peores resultados, en términos de supervivencia, que el estándar internacional. Métodos. Hemos analizado las características demográficas, indicaciones, tipos, escalas de gravedad (RTS, AIS, ISS y NISS) y TPS (TRISS Probability of Survival), así como las muertes potencialmente evitables y posibles errores de manejo inicial de los pacientes traumatizados que han necesitado una toracotomía dentro de las primeras 48 h. Resultados. Entre agosto de 1993 y agosto de 2002 se ha recogido en nuestro registro de traumatizados graves un abordaje torácico urgente, único o combinado con otras vía de abordaje, en 51 pacientes. En 26 y 25 pacientes la toracotomía fue por TP y TC, respectivamente. En el grupo con TP el tiempo medio de transporte fue de 49 min. Las indicaciones del abordaje torácico fueron: 3 casos por situación in extremis en el Departamento de Urgencias, 11 por shock al ingreso, 10 por lesiones específicas en pacientes que no estaban en shock y 2 por hemorragia persistente a través de un tubo de drenaje. Un 11,5 por ciento necesitaron abordaje toracoabdominal combinado. La lesión más frecuente fue la herida por arma blanca cardíaca AIS V. El RTS, ISS y NISS medios fueron de 8,2, 23 y 30, respectivamente. La mortalidad a 30 días fue de 7 casos (27 por ciento). En función del TPS dos de los fallecidos aparecen como muertes potencialmente evitables. En el grupo con TC el tiempo medio de transporte fue de 63 min. Las indicaciones de la toracotomía fueron: 3 casos por situación in extremis, 3 por shock al ingreso, 14 por lesiones especificas en pacientes que no estaban en shock y 5 por hemorragia torácica persistente. Un 32 por ciento necesitaron un abordaje toracoabdominal combinado. Hubo lesiones cardíacas o de grandes vasos en 11 pacientes (44 por ciento). El RTS, ISS y NISS medios fueron de 8,9, 34 y 41, respectivamente. La mortalidad a los 30 días fue de 12 casos (48 por ciento), y 2 aparecen como muertes potencialmente evitables en función del TPS. Conclusiones. En las toracotomías por TP los "tiempos de transporte" parecen prolongados a la luz de las recomendaciones de la bibliografía. La necesidad de reanimación cardiopulmonar (RCP) avanzada in situ o durante el traslado ha sido un factor de pronóstico fatal en nuestra serie. En el TC una causa muy frecuente de toracotomía urgente ha sido la rotura aórtica y de cavidades cardíacas. La necesidad de laparotomía asociada ha sido frecuente, y conlleva una alta mortalidad. La baja incidencia global de toracotomía urgente por traumatismo en nuestro medio no parece influir negativamente en los resultados de supervivencia, aunque se han detectado errores de evaluación y manejo susceptibles de corrección (AU)

[Thymectomy in myasthenia gravis]. / Timectomía en la miastenia gravis.

OBJECTIVE: To analyze outcome after thymectomy in patients with myasthenia gravis (MG). MATERIAL AND METHODS: Thirty-five patients with MG underwent surgery in our service between June 1987 and June 1998. Ten had associated thymomas. Preoperative Osserman classification showed 2 at level I, 20 at level IIA, 11 at level IIB and 2 at level III. Extended thymectomy through a medial sternotomy was performed in all. RESULTS: Postoperative complications developed in three patients (1 medullary aplasia, 1 postoperative reintubation, 1 myasthenic crisis). Mean follow-up was 89 months, with 22.8% achieving complete remission and 97.1% reporting improvements. The results were similar in the 10 patients with thymomas (20% full remission and 90% showing improvement). By DeFilippi classification, 22.8% were in class 1, 22.8% in class 2, 51.4% in class 3 and 2.8% in class 4. By Osserman classification, 9 were in the same category before and after surgery, 12 had improved one level, 10 had improved 2 levels, 3 had improved 3 levels and 1 patient had improved 4 levels. CONCLUSION: Thymectomy is an appropriate therapeutic procedure in the multidisciplinary treatment of patients with MG and it is the approach of choice for patients with associated thymomas. The intra- and post-operative complication rate is low and the rate of clinical improvement is high.

Design, synthesis, and biological evaluation of analogues of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469).

2-(4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469) is among the most highly and broadly active antitumor agents to have been evaluated in our laboratories and is currently scheduled to enter clinical trials in 2001. The mechanism or mechanisms of action of XK469 remain to be elaborated. Accordingly, an effort was initiated to establish a pharmacophore hypothesis to delineate the requirements of the active site, via a comprehensive program of synthesis of analogues of XK469 and evaluation of the effects of structural modification(s) on solid tumor activity. The strategy formulated chose to dissect the two-dimensional parent structure into three regions-I, ring A of quinoxaline; II, the hydroquinone connector linkage; and III, the lactic acid moiety-to determine the resultant in vitro and in vivo effects of chemical alterations in each region. Neither the A-ring unsubstituted nor the B-ring 3-chloro-regioisomer of XK469 showed antitumor activity. The modulating antitumor effect(s) of substituents of differing electronegativities, located at the several sites comprising the A-ring of region I, were next ascertained. Thus, a halogen substituent, located at the 7-position of a 2-(4-[(2-quinoxalinyl)oxy]phenoxy)propionic acid, generated the most highly and broadly active antitumor agents. A methyl, methoxy, or an azido substituent at this site generated a much less active structure, whereas 5-, 6-, 8-chloro-, 6-, 7-nitro, and 7-amino derivatives all proved to be essentially inactive. When the connector linkage (region II) of 1 was changed from that of a hydroquinone to either a resorcinol or a catechol derivative, all antitumor activity was lost. Of the carboxylic acid derivatives of XK469 (region III), i.e., CONH2, CONHCH3, CON(CH3)2, CONHOH, CONHNH2, CN, or CN4H (tetrazole), only the monomethyl- and N,N-dimethylamides proved to be active.

Timectomía en la miastenia gravis / Thymectomy in myasthenia gravis

OBJETIVO: Analizar los resultados de la timectomía en pacientes con miastenia gravis. MATERIAL Y MÉTODOS: Entre junio de 1987 y junio de 1998, se intervinieron en nuestro servicio 35 pacientes con miastenia gravis, en 10 de los cuales se asociaban timomas. Los pacientes se clasificaron en el preoperatorio según la clasificación de Osserman (dos grado I, 20 grado IIA, 11 grado IIB y dos grado III). En todos se realizó timectomía ampliada por esternotomía media. RESULTADOS: En 3 pacientes hubo complicaciones postoperatorias (una aplasia medular, una reintubación postoperatoria y una crisis miasténica). Tras una mediana de seguimiento de 89 meses, el 22,8 por ciento estaba en remisión completa y el 97,1 por ciento había mejorado. Los resultados son similares en los 10 pacientes con timoma (un 20 por ciento de remisiones completas y un 90 por ciento de mejorías). Según la clasificación de DeFilippi un 22,8 por ciento se encontraba en clase 1; un 22,8 por ciento, en clase 2; un 51,4 por ciento, en clase 3, y un 2,8 por ciento, en clase 4. Según la clasificación de Osserman, 9 pacientes presentaban el grado previo a la cirugía, 12 habían mejorado un grado, 10 habían mejorado 2 grados, 3 habían mejorado 3 grados y un paciente había mejorado 4 grados. CONCLUSIÓN: La timectomía es una opción terapéutica adecuada en el tratamiento multidisciplinario de los pacientes con miastenia gravis y es el tratamiento de elección en los pacientes en que se asocian timomas. El porcentaje de complicaciones intra y postoperatorias es bajo, y se obtiene un índice elevado de mejorías clínicas (AU)

The productivity of small animal species in small-scale mixed farming systems in subtropical Bolivia.

The productivity of the scavenging, small animal species (chickens, ducks, pigs, hair sheep and guinea-pigs) commonly found on small-scale farms at the forest margin in subtropical Bolivia was monitored over a full year. Chickens and guinea-pigs were kept mainly for home consumption, while ducks and pigs were kept mainly for sale. Sheep served both purposes, depending upon the family requirements. In the absence of veterinary treatment, the productivity varied greatly between farms. Pigs gave the greatest gross return, but received the largest amount of supplementary feed. Under the existing system, chickens, ducks and sheep all gave similar gross returns per breeding female, although chickens produced good returns and made a large contribution to the family diet where the reproductive efficiency was high and the chick mortality was low. Mortality resulting from disease was a major problem in poultry, while internal parasites appeared to be important limiting factors in pigs and sheep. Guinea-pigs showed no major problems apart from theft, and were an important dietary component for immigrant families from the highlands of the country. Small animal species have largely been ignored by agricultural research and development activities in Bolivia and elsewhere. They currently make significant contributions to the livelihoods of poor people in terms of both income and food security, and this could be greatly increased by simple improvements in animal husbandry.

True hermaphroditism in a horned goat with 60XX/60XY chimerism.

Anatomical, behavioral, histological, endocrinological, and cytogenetic characteristics were determined in a horned intersex goat. Histology of the gonads confirmed that the goat was a true hermaphrodite. Cytogenetic analysis showed that it was a chimera (60XX/60XY). Use of laparoscopy allowed determination of characteristics of the internal gonads.

Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17 beta: a 3D QSAR study.

Analogues of estradiol-17 beta (E2) have been evaluated for estrogen receptor (ER) binding affinity and mitogenic potential in the human breast cancer cell line MCF-7. These 42 compounds represent subtle modifications of the natural estrogen structure through the placement of hydroxyl, amino, nitro, or iodo groups around the ring system in addition to, or as replacement of, the 3- and 17 beta-hydroxyls of E2. The mitogenic activity of the analogues was found to be related to ER binding only to a limited extent. In order to elucidate structural features that are uniquely responsible for receptor binding affinity or mitogen potential of estrogens, the three-dimensional quantitative structure-activity (QSAR) method Comparative Molecular Field Analysis (CoMFA) was employed. Separate CoMFA models for receptor binding and cell growth stimulation were optimized through the use of various alignment rules and region step size. Whereas the CoMFA contour plots did outline the shared structural requirements for the two measured biological properties, specific topological features in this set of estrogens were delineated that distinguish mitogenic potential from ER binding ability. In particular, steric interference zones which affected growth extend in a band from above the A-ring to position 4 and below, whereas the ER binding steric interference zones are limited to isolated polyhedra in the 1, 2 and 4 positions and the alpha face of the B-ring. In addition, electronegative features located around the A-, B-, or C-rings contribute to receptor affinity. However, growth is dependent only on electronegative and electropositive properties near the 3-position. In a final QSAR model for the mitogenic response, the value of ER binding was included along with structural features as a descriptor in CoMFA. The resulting 3D-QSAR has the most predictive potential of the models in this study and can be considered a prototype model for the general evaluation of a steroidal estrogen's growth stimulating ability in MCF-7 cells. For example, the location of D-ring contours illustrate the model's preference for 17 beta-hydroxy steroids over the less mitogenic 17 alpha- and 16 alpha-hydroxy compounds. In addition, the enhanced mitogenic effect of steric bulk in the 11 alpha-position is also evident. The QSAR studies in this report illustrate the fact that while ER binding may be a required factor of the estrogen dependent growth response in MCF-7 cells, particular structural characteristics, in addition to those responsible for tight receptor binding, must be present to induce an optimal mitogenic response. Therefore, this report demonstrates that the CoMFA QSAR method can be utilized to characterize structural features of test compounds that account for different types of estrogenic responses.

[Short and long term follow-up of spontaneous pneumothorax treated using video-thoracoscopy]. / Seguimiento a corto y largo plazo del neumotórax espontáneo tratado por videotoracoscopia.

The outcome of video-assisted thoracoscopic treatment of spontaneous pneumothorax was analyzed. Eighty-three procedures were performed in 79 patients (58 men, 21 women: mean age 28.3 years, range 16 to 76 years). The reasons for intervention were recurring pneumothorax in 53 patients, contralateral pneumothorax in 10 (one of whom was treated on both sides), bilateral involvement in 3, and persistent air leakage in 13. Seven patients (8.4%) also required open thoracotomy. In 72 (88%) of the remaining 76 procedures, only video thoracoscopy was used. Three patients (3.6%) underwent video-assisted thoracotomy. Mean postoperative hospital stay was 5.1 days (2 to 24 days). No related deaths occurred but surgical complications were reported for 3 (3.9%). Significant postoperative complications developed in 9 cases (11.8%). One patient with prolonged air leakage underwent a second procedure, video-assisted thoracotomy, 12 days after the first intervention. Seventy-one of the 72 patients received follow-up examinations, with a mean follow-up period of 28.1 months (range 54 days to 54 months). Three recurrences (3.9%) were recorded but there were no cases of chronic pain requiring analgesia. We conclude that video thoracoscopy is an effective approach, with the advantage of being minimally invasive. We therefore believe it should be the procedure of choice, once improved morbidity and recurrence rates are observed, as these factors are influenced by the learning curve.

[Severe hypoglycemia secondary to a fibrous pleural tumor]. / Hipoglucemias severas secundarias a tumor fibroso pleural.

A case with recurrent hypoglycemias following a thoracic tumor is presented. Neurologic symptoms due to hypoglycemia were dominant. Subcutaneous somatostatin was administrated preoperatively and hypoglycemia was controlled following tumor resection. Histology analysis shows a localized fibrous pleural tumor. Origin has been widely questioned but now it is accepted to be mesenchymal and not mesothelial. Lung disease owing to chronic compression of the tumor made necessary a lobectomy. Postoperative atelectasis required reoperation and a pneumonectomy was performed. To date insulin-like factors secreted by the tumor are supposed to be responsible for hypoglycemics discharges.