Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 8 de 8
Filter
Add more filters









Database
Language
Publication year range
1.
4-Aroyl-1,3-dihydro-2H-imidazol-2-ones: a new class of cardiotonic agents. 2. Effect of 4-pyridoyl substituents and related compounds.
Schnettler, R A; Dage, R C; Palopoli, F P.
J Med Chem ; 29(5): 860-2, 1986 May.
Article in English | MEDLINE | ID: mdl-3701794

ABSTRACT

A group of 4-pyridoyl-1,3-dihydro-2H-imidazol-2-ones was prepared and tested for inotropic activity in the anesthetized dog. Positive inotropic effects as well as increases in heart rate and decreases in blood pressure were noted for most of these compounds. One of the compounds (8) is currently undergoing clinical trials for the treatment of congestive heart failure.


Subject(s)
Cardiotonic Agents/chemical synthesis , Imidazoles/chemical synthesis , Animals , Blood Pressure/drug effects , Cardiotonic Agents/pharmacology , Dogs , Heart Rate/drug effects , Imidazoles/pharmacology , Myocardial Contraction/drug effects
2.
Lack of carcinogenicity of oxprenolol, a beta-adrenergic blocking agent.
Newberne, J W; Newberne, P M; Gibson, J P; Huffman, K W; Palopoli, F P.
Toxicol Appl Pharmacol ; 41(3): 535-46, 1977 Sep.
Article in English | MEDLINE | ID: mdl-21472

Subject(s)
Carcinogens , Oxprenolol/toxicity , 2-Acetylaminofluorene , Animals , Ethanolamines/toxicity , Liver Neoplasms/chemically induced , Mice , Rats
3.
Triarylhaloethylenes as gonadotrophin inhibitors.
Palopoli, F P; Feil, V J; Holtkamp, D E; Richardson, A.
J Med Chem ; 17(12): 1333-5, 1974 Dec.
Article in English | MEDLINE | ID: mdl-4427330

Subject(s)
Ethylenes/analogs & derivatives , Gonadotropins, Pituitary/antagonists & inhibitors , Animals , Benzene Derivatives/chemical synthesis , Benzene Derivatives/pharmacology , Depression, Chemical , Ethylenes/chemical synthesis , Ethylenes/pharmacology , Hydrocarbons, Halogenated/chemical synthesis , Hydrocarbons, Halogenated/pharmacology , Male , Organ Size , Prostate/drug effects , Rats , Structure-Activity Relationship
4.
Hypolipidemic substituted 1,3-benzodioxole-2-carboxylates.
Grisar, J M; Claxton, G P; Parker, R A; Palopoli, F P; Kariya, T.
J Med Chem ; 17(7): 721-5, 1974 Jul.
Article in English | MEDLINE | ID: mdl-4836402

Subject(s)
Dioxoles/chemical synthesis , Hypolipidemic Agents/chemical synthesis , Animals , Body Weight/drug effects , Carboxylic Acids/chemical synthesis , Carboxylic Acids/pharmacology , Cholesterol/blood , Dioxoles/pharmacology , Hypolipidemic Agents/pharmacology , Liver/drug effects , Male , Organ Size , Rats , Structure-Activity Relationship , Triglycerides/blood
5.
Synthesis and hypotensive activity of N-substituted 1-trimethoxybenzyl-3-butenylamines and related compounds.
McCarty, F J; Lendvay, L J; Vazakas, A J; Bennetts, W W; Palopoli, F P.
J Med Chem ; 13(5): 814-9, 1970 Sep.
Article in English | MEDLINE | ID: mdl-5458363

Subject(s)
Amines , Amines/analysis , Amines/chemical synthesis , Amines/pharmacology , Amines/therapeutic use , Analgesics/pharmacology , Animals , Blood Pressure/drug effects , Cardiac Output/drug effects , Chemical Phenomena , Chemistry , Dogs , Heart Rate/drug effects , Hypertension, Renal/drug therapy , Isoquinolines/chemical synthesis , Male , Mice , Rats , Spectrophotometry , Vascular Resistance/drug effects
6.
N4, N4'-Decamethylenebis-4-aminopyridine and N9, N9'-decamethylenebis-9-aminoacridine.
Paolini, J P; Lendvay, L J; Palopoli, F P.
J Med Chem ; 12(4): 701-2, 1969 Jul.
Article in English | MEDLINE | ID: mdl-4978366

Subject(s)
Acridines/chemical synthesis , Pyridines/chemical synthesis , Acridines/pharmacology , Candida/drug effects , Escherichia coli/drug effects , Proteus/drug effects , Pseudomonas aeruginosa/drug effects , Pyridines/pharmacology , Trichomonas/drug effects , Trichophyton/drug effects
7.
Synthesis and pharmacology of a series of 1-aralkyl-3-butenylamines.
McCarty, F J; Rosenstock, P D; Paolini, J P; Micucci, D D; Ashton, L; Bennetts, W W; Palopoli, F P.
J Med Chem ; 11(3): 534-41, 1968 May.
Article in English | MEDLINE | ID: mdl-5656492

Subject(s)
Alkenes/chemical synthesis , Alkenes/pharmacology , Amines/chemical synthesis , Amines/pharmacology , Analgesics/pharmacology , Animals , Anti-Inflammatory Agents/pharmacology , Anticonvulsants/pharmacology , Antihypertensive Agents/pharmacology , Mice , Rats
8.
Substituted aminoalkoxytriarylhaloethylenes.
Palopoli, F P; Feil, V J; Allen, R E; Holtkamp, D E; Richardson, A.
J Med Chem ; 10(1): 84-6, 1967 Jan.
Article in English | MEDLINE | ID: mdl-6031709

Subject(s)
Gonadotropins, Pituitary/biosynthesis , Hydrocarbons, Halogenated/pharmacology , Animals , Chemical Phenomena , Chemistry , Chemistry, Organic , Ethylamines/pharmacology , Gonads/drug effects , Injections, Subcutaneous , Male , Organ Size/drug effects , Organic Chemistry Phenomena , Rats
SEND TO:
Email
Export
Print
RSS
XML
SELECTION OF CITATIONS
SEARCH DETAIL