[Bilateral hemothorax secondary to combined antiplatelet therapy with clopidogrel and acetylsalicylic acid]. / Hemotórax bilateral secundario al tratamiento antiagregante con clopidogrel y ácido acetilsalicílico.

Clopidogrel is a platelet aggregation inhibitor that increases the risk of bleeding complications when combined with acetylsalicylic acid. We report a rare case of a 79-year-old male treated with clopidogrel and acetylsalicylic acid after coronary angioplasty and stenting to treat unstable angina. Two months after initiation of therapy, the patient presented with symptomatic bilateral pleural effusion. Examination of both effusions confirmed the diagnosis of spontaneous bilateral hemothorax due to combined anti-platelet therapy. Serious functional sequelae were still present 18 months after diagnosis despite bilateral pleural drainage and respiratory physiotherapy.

Hemotórax bilateral secundario al tratamiento antiagregante con clopidogrel y ácido acetilsalicílico / Bilateral hemothorax secondary to combined antiplatelet therapy with clopidogrel and acetylsalicylic acid

El clopidogrel es un inhibidor de la agregación plaquetaria que aumenta el riesgo de complicaciones hemorrágicas cuando se combina con el ácido acetilsalicílico. Presentamos un caso excepcional en un varón de 79 años tratado con clopidogrel y ácido acetilsalicílico después de una angioplastia coronaria y la colocación de un stent por una angina inestable. A los 2 meses de tratamiento presentó un derrame pleural bilateral sintomático. El estudio de ambos derrames confirmó el diagnóstico de un hemotórax espontáneo bilateral atribuido a los antiagregantes. El drenaje pleural bilateral y la fisioterapia respiratoria no impidieron la persistencia de importantes secuelas funcionales a los 18 meses del diagnóstico

Clopidogrel is a platelet aggregation inhibitor that increases the risk of bleeding complications when combined with acetylsalicylic acid. We report a rare case of a 79-year-old male treated with clopidogrel and acetylsalicylic acid after coronary angioplasty and stenting to treat unstable angina. Two months after initiation of therapy, the patient presented with symptomatic bilateral pleural effusion. Examination of both effusions confirmed the diagnosis of spontaneous bilateral hemothorax due to combined anti-platelet therapy. Serious functional sequelae were still present 18 months after diagnosis despite bilateral pleural drainage and respiratory physiotherapy