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Aplastic anaemia after exposure to a weed killer, 2-methyl-4-chlorphenoxyacetic acid.

Palva, H L; Koivisto, O; Palva, I P.

Acta Haematol ; 53(2): 105-8, 1975.

Article in English | MEDLINE | ID: mdl-804793

ABSTRACT

A 64-year-old farmer developed aplastic anaemia after exposure to 2-methyl-4-chlorphenoxyactic acid while spraying weed killer. Muscular weakness, haemorrhagic gastritis and slight signs of liver damage occurred at the same time. All these symptoms, including blood dyscrasia , are consistent with those described as toxic effects of chlorphenoxyacetic acids in animal experiments. A causal relationship between aplastic anaemia and the 2-methyl-4-chlorphenoxyacetic acid thus seems probable. The anaemia was reversible, but the case serves as a warning that careful safety measures are required during the use of chlorphenoxyacetic acids and related compounds.

Subject(s)

2,4-Dichlorophenoxyacetic Acid/analogs & derivatives , Anemia, Aplastic/chemically induced , Herbicides/poisoning , 2,4-Dichlorophenoxyacetic Acid/poisoning , Anemia, Aplastic/blood , Anemia, Aplastic/drug therapy , Humans , Male , Middle Aged , Prednisolone/therapeutic use

Drug-induced malabsorption of vitamin B12. VII. Malabsorption of B12 treatment with potassium citrate.

Palva, I P; Salokannel, S J; Palva, H L; Rytkönen, U; Timonen, T.

Acta Med Scand ; 196(6): 525-6, 1974 Dec.

Article in English | MEDLINE | ID: mdl-4456986

Subject(s)

Intestinal Absorption/drug effects , Malabsorption Syndromes/chemically induced , Potassium/adverse effects , Vitamin B 12/metabolism , Citrates/adverse effects , Citrates/pharmacology , Citrates/therapeutic use , Cobalt Radioisotopes , Depression, Chemical , Heart Diseases/drug therapy , Humans , Hydrogen-Ion Concentration , Male , Potassium/pharmacology , Potassium/therapeutic use , Schilling Test , Vitamin B 12 Deficiency/chemically induced

Drug-induced malabsorption of vitamin B 12 . IV. Malabsorption and deficiency of B 12 during treatment with slow-release potassium chloride.

Palva, I P; Salokannel, S J; Timonen, T; Palva, H L.

Acta Med Scand ; 191(4): 355-7, 1972 Apr.

Article in English | MEDLINE | ID: mdl-5032681

Subject(s)

Intestinal Absorption/drug effects , Malabsorption Syndromes/chemically induced , Potassium Chloride/adverse effects , Vitamin B 12 Deficiency/chemically induced , Heart Diseases/drug therapy , Humans , Hydrogen-Ion Concentration , Ileum , Male , Schilling Test , Telemetry , Vitamin B 12/blood

Drug-induced malabsorption of vitamin B 12 . V. Intestinal pH and absorption of vitamin B 12 during treatment with para-aminosalicylic acid.

Palva, I P; Rytkönen, U; Alatulkkila, M; Palva, H L.

Scand J Haematol ; 9(1): 5-7, 1972.

Article in English | MEDLINE | ID: mdl-5056480

Subject(s)

Aminosalicylic Acids/adverse effects , Ileum/metabolism , Intestinal Absorption/drug effects , Vitamin B 12 Deficiency/chemically induced , Vitamin B 12/metabolism , Aminosalicylic Acids/therapeutic use , Cobalt Isotopes , Humans , Hydrogen-Ion Concentration , Intrinsic Factor/physiology , Schilling Test , Telemetry , Tuberculosis, Pulmonary/drug therapy

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