ABSTRACT
Anatomoclinical studies have been carried out on tissue samples obtained from patients with various chronic general diseases including cardiovascular diseases, diabetes, kidney diseases, liver diseases, acute and chronic leukemias, that had developed before the time when biologic therapy of the dental pulp had been recommended. In the presence of lesions of various severities of the dental pulp direct application of various biological techniques may trigger violent reactions, just as if the biological substances would represent deleterious factors. Vascular changes, followed by reactional responses in various stages of trophic changes, or dysplasia in the dental pulp, as demonstrated by microscopical studies show a certain degree of deterioration of the dental pulp which are counterindicative for biological therapy. When degenerative lesions of the pulpal connective structures, and vascular-nervous complex have occurred, or when leukemic invading processes have been identified biological therapy is completely counterindicated.
Subject(s)
Dental Care for Disabled , Dental Pulp Diseases/therapy , Root Canal Therapy , Cardiovascular Diseases , Chronic Disease , Contraindications , Dental Pulp/drug effects , Diabetes Mellitus , Humans , Kidney Diseases , Leukemia , Liver DiseasesSubject(s)
Cardiomyopathy, Hypertrophic/pathology , Death, Sudden, Cardiac/etiology , Neuroblastoma/pathology , Retroperitoneal Neoplasms/pathology , Autopsy , Brain/pathology , Cardiomyopathy, Hypertrophic/etiology , Child, Preschool , Death, Sudden, Cardiac/pathology , Humans , Male , Myocardium/pathology , Neuroblastoma/complications , Retroperitoneal Neoplasms/complicationsSubject(s)
Death, Sudden/pathology , Autopsy , Cause of Death , Death, Sudden/epidemiology , Death, Sudden/etiology , HumansSubject(s)
Sudden Infant Death/pathology , Autopsy , Humans , Infant , Infant, Newborn , Sudden Infant Death/etiologySubject(s)
Adrenal Medulla , Hypertension/therapy , Animals , Dogs , Sclerosis/chemically induced , Sodium SalicylateABSTRACT
The selective inhibitory effect of sodium salicylate (2.5 M) on the adrenal medulla was investigated histopathologically, histoenzymatically, electron microscopically and biochemically. It was proved that the different behaviour of nicotinamide-adenine dinucleotide (NAD) and nicotinamide-adenine dinucleotide phosphate (NADP) linked dehydrogenases under the action of sodium salicylate can account for the survival of cortical cells, while the medullar ones are necrosed.