ABSTRACT
The aim of this study was to summarize results on the association of tumor necrosis factor-α (TNF-α) promoter -308A/G polymorphism with systemic lupus erythematosus (SLE) susceptibility in Asian populations by using the meta-analysis. We searched all the publications about the association between TNF-α promoter -308A/G polymorphism and SLE in Asian populations from PubMed, Elsevier Science Direct, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), and Wanfang (Chinese). Meta-analysis was performed for genotypes AA versus GG, GA versus GG, AA versus GG + GA, GA + AA versus GG, and A allele versus G allele in a fixed/random effect model. A total of 12 studies (1017 cases and 1086 controls) were included in the current meta-analysis (Chinese, Japanese, and Thai). When all groups were pooled, a significant association of A allele and increased SLE risk was found (OR = 1.44, 95%CI = 1.04-2.01, P = 0.03). When analyses were restricted to more ethnically homogeneous populations, similar result was found in Chinese population (OR = 1.59, 95%CI = 1.12-2.26, P = 0.009). But the association between TNF-α promoter -308 polymorphism and SLE was not observed when examining the contrast of G/A + A/A versus G/G, A/A versus A/G + G/G, A/A versus G/G, and G/A versus G/G. This meta-analysis demonstrates the association between TNF-α promoter -308A/G polymorphism and SLE in Asian populations, especially in Chinese population.
Subject(s)
Genetic Predisposition to Disease , Lupus Erythematosus, Systemic/genetics , Polymorphism, Single Nucleotide , Tumor Necrosis Factor-alpha/genetics , Asian People , China/ethnology , Humans , Lupus Erythematosus, Systemic/ethnology , Promoter Regions, Genetic , Risk FactorsABSTRACT
The aim of our meta-analysis was to quantitatively summarize the association of TYK2 gene polymorphisms with autoimmune and inflammatory diseases. 11 studies that included data from 21497 cases and 22647 controls were identified. OR was used as a measure of the effect of the association in a fixed/random effect model. Meta-analysis was performed for six TYK2 gene polymorphisms (rs34536443, rs2304256, rs280523, rs280519, rs12720270 and rs12720356). Significant association was found in rs34536443 (C versus G: OR = 0.76, 95% CI = 0.69-0.84, P < 0.00001; GC + CC versus GG: OR = 0.78, 95% CI = 0.68-0.90, P = 0.0005; CC versus GG + GC: OR = 0.76, 95% CI = 0.28-2.05, P = 0.58; CC versus GG: OR = 0.74, 95% CI = 0.27-2.02, P = 0.56; GC versus GG: OR = 0.78, 95% CI = 0.68-0.90, P = 0.0006) and rs2304256 (A versus C: OR = 0.78, 95% CI = 0.70-0.87, P < 0.0001; CA + AA versus CC: OR = 0.69, 95% CI = 0.59-0.81, P < 0.0001; AA versus CC + CA: OR = 0.75, 95% CI = 0.66-1.00, P = 0.05; AA versus CC: OR = 0.64, 95% CI = 0.47-0.86, P = 0.003; CA versus CC: OR = 0.70, 95% CI = 0.60-0.83, P < 0.0001) in TYK2 gene, but not for the other polymorphisms (rs280523, rs280519, rs12720270, and rs12720356). This meta-analysis demonstrates that autoimmune and inflammatory diseases is associated with TYK2 gene rs34536443 and rs2304256 polymorphisms, but not rs280523, rs280519, rs12720270 and rs12720356.
Subject(s)
Autoimmune Diseases/genetics , Genetic Association Studies , Genetic Predisposition to Disease , Inflammation/genetics , Polymorphism, Single Nucleotide/genetics , TYK2 Kinase/genetics , Autoimmune Diseases/enzymology , Humans , Inflammation/enzymology , Linear Models , PubMed , Publication BiasABSTRACT
The tumor necrosis factor-alpha (TNF-alpha) promoter--238A/G polymorphism has been repeatedly associated with systemic lupus erythematosus (SLE), but findings are not consistent across studies. Our aim was to do a meta-analysis to assess the association between TNF-alpha promoter--238A/G polymorphism and SLE. Eleven published studies of this polymorphism with SLE in different ethnic groups were identified using a Medline search. Meta-analysis was performed for genotypes AA versus GG, GA versus GG, AA versus GG+GA, GA+AA versus GG, and A allele versus G allele in a fixed/random effect model. The overall odds ratio (OR) of the AA versus GG+GA genotypes was 3.46 (95% CI = 1.35-8.83, P = 0.01), and a similar result was found in Caucasian population (OR = 4.62, 95% CI = 1.20-17.80, P = 0.03); the overall OR of the AA versus GG genotypes was 3.36 (95% CI = 1.32-8.55, P = 0.01), and a similar result was found in Caucasian population (OR = 4.29, 95% CI = 1.11-16.53, P = 0.03); the OR of the GA versus GG genotypes was 0.48 (95% CI = 0.30-0.75, P = 0.001) in Caucasian population. In conclusion, this meta-analysis demonstrates the association between TNF-alpha promoter - 238A/G polymorphism and SLE, especially in Caucasian population.
