Mesoscale Modeling Study on Mechanical Deterioration of Alkali-Aggregate Reaction-Affected Concrete.

The alkali-aggregate reaction (AAR) is a harmful chemical reaction that reduces the mechanical properties and weakens the durability of concrete. Different types of activated aggregates may result in various AAR modes, which affect the mechanical deterioration of concrete. In this paper, the aggregate expansion model and the gel pocket model are considered to represent the two well-recognized AAR modes. The mesoscale particle model of concrete was presented to model the AAR expansion process and the splitting tensile behavior of AAR-affected concrete. The numerical results show that different AAR modes have a great influence on the development of AAR in terms of expansion and microcracks and the deterioration of concrete specimens. The AAR mode of the gel pocket model causes slight expansion, but generates microcracks in the concrete at the early stage of AAR. This means there is difficulty in achieving early warning and timely maintenance of AAR-affected concrete structures based on the monitoring expansion. Compared with the aggregate expansion model, more severe cracking can be observed, and a greater loss of tensile strength is achieved at the same AAR expansion in the gel pocket model. AAR modes determine the subsequent reaction process and deterioration, and thus, it is necessary to develop effective detection methods and standards for large concrete projects according to different reactive aggregates.

Selenium Protects against Zearalenone-Induced Oxidative Stress and Apoptosis in the Mouse Kidney by Inhibiting Endoplasmic Reticulum Stress.

This study assessed the molecular mechanism of selenium (Se) protecting against kidney injury induced by zearalenone (ZEA) in mice. The experimental mice were divided into 4 groups including the control group, the Se group, the ZEA group, and the Se+ZEA group; ZEA and Se were administered orally for 28 days. The changes in renal biochemical index (BUN, UA, and CRE), biochemical change of kidney damage such as BUN, UA, and CRE, and oxidative damage such as MDA, T-SOD, and GSH-Px were investigated. Pathological sections and TUNEL staining were used to analyze renal pathological changes and cell apoptosis. qRT-PCR and Western blot were employed to detect the expression of genes and proteins which were related with endoplasmic reticulum stress. The results showed that ZEA increased the concentration of BUN, UA, and CRE and the content of MDA and decreased the activities of T-SOD and GSH-Px in the mouse kidneys. However, Se reversed above changes of the biochemical and antioxidant indexes of renal injury. Moreover, the results also showed that ZEA can increase the expression of Bax, caspase-12, caspase-3, Bip, CHOP, JNK protein, and mRNA and decrease the expression of Bcl-2 protein and mRNA. But Se reversed these proteins and genes related to endoplasmic reticulum stress and apoptosis. It can be concluded that Se protected against the kidney damage induced by ZEA. Se may protect the kidney from ZEA-induced apoptosis and oxidative stress by inhibiting ERS.

Mechanism for large-scale canyon deformations due to filling of large reservoir of hydropower project.

Large storage dam projects may modify geo-environmental conditions in many ways. The reservoir impoundment of the 285.5 m high Xiluodu arch dam located on the Jinsha River (China) caused large-scale canyon deformations, including significant canyon contraction and uplift movements from reservoir to downstream valley. The dam experienced subsequent tilting towards upstream and raised a safety concern of the project. A Thermo-Hydro-Mechanical (THM) mechanism is proposed for this extraordinary behavior. Due to reservoir impounding and seepage, significant temperature drops and fluid pressure increase within the underlying geothermal limestone aquifer in a synclinal basin are primary root causes. Finite element THM simulations successfully reproduce these unique deformations. Recent observations of large quantities of thermalized discharge water downstream and high pore pressure in the limestone layer provide further support for the proposed mechanism. Furthermore, refined numerical modeling is adopted to evaluate the safety of Xiluodu dam subjected to potential larger canyon contractions. We conclude that these unprecedented phenomena are dominantly the consequence of THM response to regional hydrogeological evolution following the build-up of a large reservoir. The accumulated canyon contractions at the current stage would not pose a direct threat to the dam safety, but a tripled situation may cause severe safety issues.

Author Correction: Nano-scale structure and mechanical properties of ASR products under saturated and dry conditions.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Nano-scale structure and mechanical properties of ASR products under saturated and dry conditions.

Alkali-silica reaction (ASR) widely occurs in concrete, resulting in durability problem and premature loss in serviceability of infrastructures all over the world. Understanding of the properties of ASR products, especially at micro scale level, helps mitigation of deterioration in concrete structures. In this study, the nano-scale structure and mechanical properties of the ASR products under dry and saturated conditions are investigated. The scanning electron microscope and energy dispersive spectrometer with X-ray (SEM-EDS) and atomic force microscope (AFM), as well as the nanoindentation are applied to the ASR products. The experimental observation indicates the effect of water on the micromorphology and nano-scale mechanical properties of ASR products. Water makes contribution to the transformation of ASR products from solid to viscous gels and the decrease in the Young's modulus and hardness of ASR products. The testing results reveal the correlation between nano-scale structure and mechanical properties and improve the understanding of the micromechanical behavior of ASR products.

Filling Capacity Evaluation of Self-Compacting Concrete in Rock-Filled Concrete.

The good filling performance of self-compacting concrete (SCC) to pre-placed assembly of rocks is essential for quality of rock-filled concrete (RFC). In this study, a theoretical model is proposed to evaluate the filling capacity of SCC in porous media that is simplified to approximate the assembly of rocks. Numerical simulation of SCC flow in the porous media is carried out based on the computational fluid dynamics. The effects of yield stress of SCC and size and shape of grains in the porous media on the filling capacity of SCC are considered. The inclination of the free surface of the distribution of SCC at flow stoppage is defined to evaluate the filling capacity of SCC in the porous media. According to the theoretical model, the inclination is directly proportional to the yield stress of the SCC and the blocking effect of grains, while inversely proportional to the grain size. The numerical simulation provides consistent results with the theoretical model. The results suggest the use of rounded large rocks and SCC with low yield stress to ensure good quality of RFC.

Pediococcus pentosaceus xy46 Can Absorb Zearalenone and Alleviate its Toxicity to the Reproductive Systems of Male Mice.

Zearalenone (ZEA) contamination is a very serious problem around the world as it can induce reproductive disorders in animals and affect the health of humans. Therefore, reducing the damage it causes to humans and animals is a current focus of research. In this study, we assess the removing capacity of Pediococcus pentosaceus xy46 towards ZEA and investigate the mechanism responsible for its action, thus confirming if it can alleviate ZEA toxicity to the reproductive systems of male mice. Our results show that the rate at which the strain removes ZEA is as high as 89.2% in 48 h when the concentration of ZEA is 4 µg/mL in the liquid medium. Heat and acid treatment significantly enhanced the ability of the bacteria to remove ZEA. The animal experiments results show that the oral administration of xy46 to mice (0.2 mL daily at a concentration of 109 CFU/mL for 28 days) significantly reduces the degree of testicular pathomorphological changes and apoptosis induced by ZEA when the mice are intragastric administration with 40 mg/kg ZEA daily for 28 days. Moreover, oral administration of xy46 enhances the decrease in the testosterone level and improves the oxidative stress injury induced by ZEA. Furthermore, oral administration of xy46 reverts the expression of these genes and proteins in the testicular tissues of the mice involved in the blood-testis barrier and apoptosis (e.g., Vim, caspase 12, Cldn11, N-cad, Bax, and Bcl-2). However, xy46 cannot significantly revert in some of these evaluated parameters, especially in sperm quantity and quality when the mice were given 70 mg/kg ZEA daily for 28 days. In conclusion, our results suggest that the strain Pediococcus pentosaceus xy46 can efficiently remove ZEA from the liquid medium, the mechanism responsible for its action is absorption, and it can alleviate the toxicity of ZEA to the reproductive systems of male mice when the mice are given 40 mg/kg ZEA daily, However, it cannot completely alleviate the reproductive toxicity of higher dosage of zearalenone through its ability to adsorb ZEA.

Neurotoxicity of low bisphenol A (BPA) exposure for young male mice: Implications for children exposed to environmental levels of BPA.

To investigate the neuron toxicities of low-dose exposure to bisphenol A (BPA) in children, mice were used as an animal model. We examined brain cell damage and the effects of learning and memory ability after BPA exposure in male mice (4 weeks of age) that were divided into four groups and chronically received different BPA treatments for 8 weeks. The comet assay and hippocampal neuron counting were used to detect the brain cell damage. The Y-maze test was applied to test alterations in learning and memory ability. Long term potentiation induction by BPA exposure was performed to study the potential mechanism of performance. The percentages of tail DNA, tail length and tail moment in brain cells increased with increasing BPA exposure concentrations. Significant differences in DNA damage were observed among the groups, including between the low-dose and control groups. In the Y-maze test, the other three groups qualified for the learned standard one day earlier than the high-exposed group. Furthermore, the ratio of qualified mice in the high-exposed group was always the lowest among the groups, indicating that high BPA treatment significantly altered the spatial memory performance of mice. Different BPA treatments exerted different effects on the neuron numbers of different regions in the hippocampus. In the CA1 region, the high-exposed group had a significant decrease in neuron numbers. A non-monotonic relationship was observed between the exposure concentrations and neuron quantity in the CA3 region. The hippocampal slices in the control and medium-exposed groups generated long-term potentiation after induction by theta burst stimulation, but the low-exposed group did not. A significant difference was observed between the control and low-exposed groups. In conclusion, chronic exposure to a low level of BPA had adverse effects on brain cells and altered the learning and memory ability of adolescent mice.