1.
Chem Commun (Camb)
; 54(98): 13841-13844, 2018 Dec 06.
Article
in English
| MEDLINE
| ID: mdl-30468218
ABSTRACT
A novel, simple, one-step and one-tube detection method was developed for ultrasensitive detection of polynucleotide kinase (PNK) activity on the basis of dual enzyme-synergistic signal amplification. This method was also demonstrated to work well for PNK inhibitor screening and endogenous PNK detection in cell lysates at a single-cell level.