Subject(s)
Thymoma/diagnosis , Thymus Neoplasms/diagnosis , Female , Hepatomegaly/complications , Humans , Middle Aged , Radiography, Thoracic , Recurrence , Respiratory Tract Infections/complications , Splenomegaly/complications , Thymoma/complications , Thymoma/surgery , Thymus Neoplasms/complications , Thymus Neoplasms/surgery , Tomography, X-Ray ComputedSubject(s)
Antigens, Neoplasm/analysis , Biomarkers, Tumor/analysis , Lymphoma, Non-Hodgkin/chemistry , Proliferating Cell Nuclear Antigen/analysis , Adult , Aged , Aged, 80 and over , Female , Humans , Immunoenzyme Techniques , Lymphoma, Non-Hodgkin/diagnosis , Lymphoma, Non-Hodgkin/mortality , Lymphoma, Non-Hodgkin/pathology , Male , Middle Aged , Paraffin Embedding , PrognosisABSTRACT
We report a new case of primary gastric plasmacytoma. The presenting symptoms was upper gastrointestinal bleeding, and the diagnosis was made preoperatively by means of gastroscopically obtained biopsy material. The demonstration of a single type of IgA-kappa immunoglobulin in plasma cells infiltrating the gastric antrum is considered conclusive evidence of its neoplastic nature. Endoscopically, the gastric plasmacytoma progresses from a benign antral ulcer (0.5 cm in diameter) to an ulcerated mass (7 cm in diameter) in an 8-wk period, suggesting rapid tumoral growth of a kind not described in the revised literature.
Subject(s)
Gastrointestinal Hemorrhage/etiology , Plasmacytoma/complications , Stomach Neoplasms/complications , Biopsy , Gastric Mucosa/pathology , Humans , Male , Middle Aged , Plasmacytoma/pathology , Stomach Neoplasms/pathologyABSTRACT
PURPOSE: The purpose of this study is to demonstrate that flow cytometric measurement of DNA content and cell proliferation is useful and provides significant information about the diagnosis and prognosis of non Hodgkin lymphoma. PATIENTS AND METHODS: Clinical and histologic information of 66 lymphoma patients was registered at diagnosis. Fifty thick sections of lymphoma samples and 67 control samples were deparaffined, rehydrated, dissected and DNA stained using a modification of the method described by Hedley. We have studied the relationship between flow cytometric results and clinical, histologic, treatment outcome and prognosis of lymphoma. RESULTS AND CONCLUSIONS: No DNA aneuploid histograms were obtained from the control non neoplastic, lymphoid samples. Side scatter light values were significantly larger in high grade lymphomas. DNA content didn't show any correlation with clinical presentation and evolution of lymphoma, however, DNA aneuploidy was more frequent in high grade lymphomas (p = 0.0172), and in these patients, aneuploidy was related to with a lower percentage of complete remission achievement (p = 0.0248). A high S phase was associated with shorter survival in patients without remission post-treatment (p < 0.0001) and in low grade lymphomas (p = 0.0174). In conclusion, our data suggest that DNA flow cytometric study provides useful information for the diagnosis of lymphoma and identifies different prognostic groups of patients.
Subject(s)
Cell Cycle/genetics , DNA, Neoplasm/analysis , Lymphoma, Non-Hodgkin/genetics , Aneuploidy , Disease-Free Survival , Flow Cytometry , Humans , Lymphoma, Non-Hodgkin/pathology , PrognosisABSTRACT
A case is presented of a woman with Von Recklinghausen's neurofibromatosis and intestinal affectation manifested as recurrent episodes of gastrointestinal bleeding. The literature is commented and a review is made of both the clinical manifestations and evolution of gastrointestinal affectation in this disease which, with other alterations, configure the ample pathologic spectrum that characterizes Von Recklinghausen's neurofibromatosis.
Subject(s)
Gastrointestinal Hemorrhage/etiology , Jejunal Neoplasms/complications , Neurofibromatosis 1/complications , Female , Humans , Jejunal Neoplasms/pathology , Middle Aged , Neurofibromatosis 1/pathology , RecurrenceABSTRACT
Authors report three cases of congenital mesoblastic nephroma. In two of them, diagnosis was neonatal, while the third was made at the 3rd-month. They discuss diagnostic procedures employed as well as pathological findings. Presence of a mass was the first clinical sign in all three cases. Nephrectomy was the only treatment employed, with favourable outcome.
Subject(s)
Kidney Neoplasms/congenital , Wilms Tumor/congenital , Female , Humans , Infant , Infant, Newborn , Kidney Neoplasms/diagnostic imaging , Kidney Neoplasms/pathology , Male , Radiography , Wilms Tumor/diagnostic imaging , Wilms Tumor/pathologyABSTRACT
Two new cases of cystic partially differentiated nephroblastoma, which were treated by nephrectomy, are reported. Their gross appearance is undistinguishable from a multilocular cyst, with the only difference being the presence of buds of blastema within the cystic septa. While cystic partially differentiated nephroblastoma as well as multilocular cyst have never been reported to be associated with local or metastatic recurrence and therefore their treatment consists of simple nephrectomy, the presence of blastema suggests a differentiates stage of Wilms' tumor, thus demanding a close surveillance of the patient.
