ABSTRACT
The performed studies showed that patients with active phase pulmonary tuberculosis have their T-system function suppressed, that of B-system activated, this phenomenon being the most marked in those patients with fibrocavernous tuberculosis. Increase in the activity of phagocytes was more common in patients with infiltrative tuberculosis. The immunity system state in subjects with non-active post tuberculous alterations did not depart from normal values. DNA and RNA concentrations were decreased in those patients having more pronounced immunologic disturbances (infiltrative and fibrocavernous tuberculosis), reparative capacity of RNA being altered only in patients with focal tuberculosis. Strong correlation was established between immunologic and cytogenetic indices.
Subject(s)
Tuberculosis, Pulmonary/genetics , Tuberculosis, Pulmonary/immunology , B-Lymphocytes/immunology , B-Lymphocytes/metabolism , DNA/blood , DNA Repair , Humans , Neutrophils/immunology , Neutrophils/metabolism , Phagocytes/immunology , Phagocytes/metabolism , RNA/blood , T-Lymphocytes/immunology , T-Lymphocytes/metabolism , Tuberculosis, Miliary/blood , Tuberculosis, Miliary/genetics , Tuberculosis, Miliary/immunology , Tuberculosis, Pulmonary/bloodABSTRACT
Characteristic features of the clinical course and immune status were studied in 24 histiocytosis X patients. Immunologic studies were carried out in 15 histiocytosis X patients by the methods that characterize the T- and B-lymphocyte systems, their sensitivity to tuberculin, the receptor apparatus of lymphocytes and neutrophilic granulocytes and autoimmune processes. The immune status of these patients is distinguished by disorders caused by secondary cellular deficit combined with the imbalance of the immunoregulatory cell system. Disorders of the B-cell link of the immune system are less pronounced and there is a drop in the production of natural antibodies and IgM. A high degree of sensitization to tuberculin was detected in the in vivo and in vitro tests, which indirectly testifies to the tuberculous origin of histiocytosis X.
Subject(s)
Histiocytosis, Langerhans-Cell/immunology , Adolescent , Adult , B-Lymphocytes/immunology , Female , Histiocytosis, Langerhans-Cell/diagnosis , Humans , Immunoglobulins/analysis , Male , Middle Aged , Rosette Formation , T-Lymphocytes/immunology , Tuberculin TestABSTRACT
Data are reported of a comparison of the clinico-immunological efficacy of hemo- and enterosorption in the complex treatment of patients with chronic asthmatic bronchitis. It was found that both sorption methods associated with adequate drug treatment produce a pronounced immunocorrective effect but hemosorption normalizes more quickly the functional activity of T-lymphocytes and number of circulating immune complexes while enterosorption normalizes more quickly the number of T-lymphocytes.
Subject(s)
Asthma/therapy , Bronchitis/therapy , Hemoperfusion , Adsorption , Chronic Disease , Combined Modality Therapy , Evaluation Studies as Topic , Humans , MethodsABSTRACT
A decrease in the concentration of high density cholesterol lipoproteins (HDCSLP) and an increase in the atherogeny index were observed in patients with diabetes mellitus, regardless the sex and age. The blood HDCSLP content is lower in males, suffering from the II and III stage ischemic heart disease, aggravated by diabetes mellitus comparatively to that of the females. Diabetes mellitus compensation promotes HDCSLP rising, nevertheless not acquiring the control level.
