ABSTRACT
A rare observation of ossifying fibromyxoid tumor of the larynx in a 23-year-old young man is presented. Surgical intervention, performed in two stages, provided a positive result. With dynamic observation of this patient for three years, continued growth and tumor recurrence were not observed. Due to the fact that ossifying fibromyxoid tumor is rare, differs in the complexity of differential diagnosis and an uncertain prognosis of the course of the disease, registration and dispensary observation of patients with this pathology is necessary.
Subject(s)
Fibroma, Ossifying , Fibroma , Soft Tissue Neoplasms , Adult , Diagnosis, Differential , Fibroma/diagnosis , Fibroma, Ossifying/diagnostic imaging , Fibroma, Ossifying/surgery , Humans , Male , Neoplasm Recurrence, Local , Soft Tissue Neoplasms/diagnosis , Young AdultABSTRACT
The objective of the present work was to improve the quality of diagnostics and treatment of hypervascular masses in ENT structures based on the multidisciplinary approach. The study involved 51 patients presenting with hypervascular masses in ENT structures. All of them underwent comprehensive medical examination including fibrolaringoscopy, multispiral computed tomography, magnetic resonance tomography, ultrasound dopplerography, selective carotid angiography, and/or various combinations of these techniques. The patients were given surgical, endovascular, and combined treatments. The study has demonstrated the advantages of application of the multidisciplinary approach to combined diagnostics and treatment of hypervascular masses in ENT structures as exemplified by neck hemangioma.
Subject(s)
Angiography/methods , Endoscopy/methods , Hemangioma/diagnosis , Multidetector Computed Tomography/methods , Nose Neoplasms/diagnosis , Otorhinolaryngologic Surgical Procedures/methods , Diagnosis, Differential , Female , Hemangioma/surgery , Humans , Middle Aged , Nose Neoplasms/surgeryABSTRACT
The objective of the present study was to estimate the possibilities and prospects for the use of regional intra-arterial chemotherapy in the combined treatment of locally advanced laryngeal cancer. The results of the chemoradiotherapeutic treatment of 26 patients presenting with locally advanced laryngeal cancer were analysed. The chemical agents were selectively administered intra-arterially three times from the right-hand femoral access by the standard procedure at a total focal dose (TFD) of 26 and 50 gram prior to the onset of and during of radiotherapy. The very first administration of the chemical agent resulted in the 30% decrease the tumour size. It further decreased by 70% on the average after the TFD of 50 gram was achieved. It made possible the continuation of gamma-therapy up to the total therapeutic dose. As a result, complete regression of the tumour was documented. The dynamic endoscopic control study and CT of the larynx revealed recurrent laryngeal cancer in 1 of the 26 patients (3.8%). The remaining patients did not develop metastases during the 18 month follow-up period. It is concluded that the results of the present study confirm high (96.2%) effectiveness of the method employed in this study which allows it to be recommended for the organ-preserving treatment of locally advanced laryngeal cancer.
Subject(s)
Antineoplastic Agents/administration & dosage , Laryngeal Neoplasms/drug therapy , Aged , Angiography , Dose-Response Relationship, Drug , Follow-Up Studies , Humans , Infusions, Intra-Arterial , Laryngeal Neoplasms/diagnosis , Laryngeal Neoplasms/radiotherapy , Male , Middle Aged , Radiotherapy, Adjuvant , Treatment OutcomeABSTRACT
The objective of the present study was to evaluate effectiveness of secretolytic, secreto-stimulating therapy in 40 patients presenting with acute rhinosinusitis. It was confirmed that acute inflammation results in suppression of local protective mechanisms acting in nasal cavity mucosa. Secretolytic and anti-inflammatory activity of Sinuforte was shown to induce these mechanisms; there is correlation between this effect and clinical picture of the disease. Parallel analysis of the results of traditional treatment of sinusitis and secretolytic, secretion-stimulating therapy has demonstrated high efficiency of the latter modality in patients suffering acute rhinosinusitis.
Subject(s)
Anti-Inflammatory Agents/therapeutic use , Exudates and Transudates/drug effects , Rhinitis/drug therapy , Sinusitis/drug therapy , Adult , Female , Humans , Male , Middle Aged , Nasal Mucosa/drug effects , Nasal Mucosa/metabolism , Radiography , Rhinitis/diagnostic imaging , Rhinitis/parasitology , Rhinitis/pathology , Sinusitis/diagnostic imaging , Sinusitis/pathology , Treatment Outcome , Young AdultABSTRACT
The objective of the present study was to analyse results of fibrolaryngoscopic examination of pretumorous and tumorous laryngeal structures in 75 patients aged from 17 to 78 years who underwent repeated laryngeal biopsies to confirm suspected diagnosis of cancer. Vital staining of affected mucosal areas with a 1% methylene blue solution was used for the purpose. It was found that malignant tumours coloured violet as they readily absorbed the dye while its fixation by dysplastic tissue produced all shades of blue depending on the degree of dysplasia. It is concluded that the method employed in this study increases the informative value of clinical and histological diagnosis and thereby permits to avoid the use of additional diagnostic procedures.
