Laparoscopic versus open appendicectomy for complicated appendicitis in children: A systematic review and meta-analysis.

BACKGROUND: Laparoscopic appendectomy (LA) is the preferred approach in uncomplicated appendicitis. However, in patients with complicated appendicitis (CA), the best approach is still unclear though laparoscopy is being increasingly preferred over open appendicectomy (OA) nowadays. AIM: To comprehensively review the current literature and compare the associations of LA and OA concerning various postoperative outcomes in order to determine the best approach for children with CA. METHODS: The PRISMA guidelines were adhered to and an electronic database search was extensively performed. Data analysis, including subgroup analysis of randomized-control trials, was performed using RevMan 5.3. Methodological and statistical heterogeneity, as well as publication bias of the included studies, were assessed. RESULTS: Four randomized controlled trials (266 LA versus 354 OA) and thirty-six case-controlled trials (2580 LA versus 3043 OA) were included in the analysis. Compared to OA, LA has a shorter length of stay, a lower rate of surgical site infection as well as a significantly lower overall complication rate. The rates of intraabdominal abscess formation, post-operative fever, pneumonia and ileus are similar in the two groups. So are the rates of readmissions and reoperations. LA was also shown to have a shorter time taken to oral intake and a lesser requirement of analgesics as well as intravenous antibiotics. Operative time for OA was found to be significantly shorter than that for LA. CONCLUSION: This meta-analysis objectively demonstrates that laparoscopy has a better overall complication profile compared to OA and should be the procedure of choice in children with complicated appendicitis.

Role of endoscopic treatment of vesico-ureteric reflux in downgrading renin angiotensin system activation.

OBJECTIVES: The objective of this study was to assess the role of endoscopic treatment of vesico-ureteric reflux (VUR) in downgrading renin angiotensin system (RAS) activation. METHODS: Of 115 patients diagnosed and treated for VUR, 63 underwent hyaluronic acid/dextranomer (deflux) injection in a total of 99 ureteric moieties. Patients were monitored for urinary tract infection (UTI), glomerular filtration rate (GFR), plasma renin activity (PRA), renal scarring, persistence, or appearance of contra-lateral reflux. RESULTS: Grade III VUR was most common (38%), and the most common cause of VUR was primary (60%). Analysis of patient characteristics at presentation revealed increased PRA in most cases (68%). Grade I VUR showed the most avid decrease in serum PRA levels after single injection. Serum PRA levels were sustainably low in patients of grade I and II VUR, whereas in patients of grade III values kept rising after reaching nadir. This increase in PRA levels correlated well with persistence of symptoms and reappearance of VUR in some patients. CONCLUSION: PRA levels can be used as an indicator to initiate treatment of VUR. They can also be used for monitoring the progress of the disease and efficacy of the treatment given.

Endoscopic treatment of vesico-ureteral reflux: Experience of 99 ureteric moieties.

AIMS: To study the outcome of endoscopic hyaluronic acid/dextranomer injection in patients with vesico-ureteric reflux (VUR). MATERIALS AND METHODS: Sixty-three children were evaluated with a median follow up of 18 months (12-55 months) before injecting hyaluronic acid/dextranomer in a total of 99 ureteric moieties. Median age at presentation was 24 months (6-72 months). Primary VUR was the main presenting diagnosis in 60%. Patients were monitored for urinary tract infection (UTI), glomerular filtration rate (GFR), renal scarring, persistence, or appearance of contra-lateral reflux. RESULTS: Grade III VUR was the most common (38%) followed by Grade IV (24%), Grade V (17%), Grade II (14%), and Grade I (7%). Most common cause for VUR was Primary (60%), followed by posterior urethral valve (PUV) (19%), bladder exstrophy (5%), anorectal malformation (ARM), epispadias, and duplex system. Analysis of patients characteristics at presentation revealed renal scarring (40%), split renal functions <35% (35%), recurrent UTI (15%), GFR <50 ml/min/1.73 m(2) (15%), serum creatinine >1.4 mg/dL (10%). Complete resolution (100%) of Grade I and Grade II VUR was achieved after single injection. For Grade III VUR, single injection resolved reflux in 85.5% ureters, 100% resolution was seen after 2(nd) injection. In Grade IV VUR, 1(st) injection resolved VUR in 83.3% ureters, 95.8% ureters were reflux free after 2(nd) injection, and 100% resolution was seen after 3(rd) injection. In Grade V VUR, 94% ureters showed absent reflux after three injections. CONCLUSION: Hyaluronic acid/dextranomer injection holds promise even in higher grades of VUR.

Presence of hernia sac in prediction of postoperative outcome in congenital diaphragmatic hernia.

We conducted this study to assess the value of presence of hernia sac in prediction of postoperative outcome in congenital diaphragmatic hernia (CDH). Data were obtained form medical records of 70 children operated for CDH between 2002-12. Postoperative neonatal death occurred in 1/10 (10%) of infants with a hernia sac and 26/60 (43.3%) in cases without a hernia sac, respectively (P =0.04). Perinatal morbidity in surviving infants was lower in the group with a hernia sac although not significantly. We conclude that the presence of a hernia sac is associated with better postoperative outcome and overall prognosis of CDH.

Effect of ipsilateral ureteric obstruction on contralateral kidney and role of renin angiotensin system blockade on renal recovery in experimentally induced unilateral ureteric obstruction.

AIMS: To study, the effects of ipsilateral ureteric obstruction on contralateral kidney and the role of renin angiotensin system (RAS) blockade on renal recovery in experimentally induced unilateral ureteric obstruction. MATERIALS AND METHODS: Unilateral upper ureteric obstruction was created in 96 adult Wistar rats that were reversed after pre-determined intervals. Losartan and Enalapril were given to different subgroups of rats following relief of obstruction. RESULTS: The severity of dilatation on the contralateral kidney varied with duration of ipsilateral obstruction longer the duration more severe the dilatation. There is direct correlation between renal parenchymal damage, pelvi-ureteric junction (PUJ) fibrosis, inflammation and severity of pelvi-calyceal system dilatation of contralateral kidney with duration of ipsilateral PUJ obstruction. CONCLUSIONS: Considerable injury is also inflicted to the contralateral normal kidney while ipsilateral kidney remains obstructed. Use of RAS blocking drugs has been found to significantly improve renal recovery on the contralateral kidney. It can, thus, be postulated that contralateral renal parenchymal injury was mediated through activation of RAS.