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J Am Chem Soc ; 128(35): 11342-3, 2006 Sep 06.
Article in English | MEDLINE | ID: mdl-16939243

ABSTRACT

Nanocompatible chemistry which utilizes a novel nontoxic phosphino amino acid as a reducing agent has resulted in the development of therapeutically useful gold nanoparticles under biologically benign media. Stabilization of gold nanoparticles by the edible gum arabic matrix has provided an effective pathway toward in vivo stable target-specific gold nanoparticles.


Subject(s)
Biocompatible Materials/chemistry , Gold/chemistry , Metal Nanoparticles/chemistry , Nanomedicine , Animals , Biocompatible Materials/pharmacokinetics , Drug Stability , Gold/pharmacokinetics , Mice , Mice, Inbred Strains , Microscopy, Electron, Transmission , Particle Size , Surface Properties , Tissue Distribution
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