[Usage of flavonoids for effective correction of functional and structural breaches of erythrocytes membranes during an extraordinary physical strain in experiments].

The effect of treatment course of bioflavonoids quercetin and diquertin on phospholipids and fatty acid composition of erythrocytes membranes and amilorid-dependent activity Na+/H+ transmembrane exchanger of erythrocytes have been studied in condition of chronic physical tension in mice in consequence of extraordinary running strain. The studied drugs actively prevented from the changes of chemical composition and as a result structural and functional changes of erythrocytes membranes. It is established that the studied bioflavonoids prevented from the development of extraordinary physical strain syndrome.

[Flavonoid correction of functional elasticity of erythrocyte membranes and hemorheological disorders during oxidative stress caused by chronic physical overstrain in mice].

Effect of a course of treatment by bioflavonoids quercetin and diquertin on the physical work capacity, oxidant and antioxidant status of organism, and hemorheological parameters and deformability of erythrocytes have been studied under conditions of chronic physical overstrain in mice caused by sequential extraordinary running load. The drugs effectively prevent the development of oxidative stress, loss of elasticity of erythrocyte membranes and growth in dynamic blood viscosity in microcirculatory link of hemodynamics. It is established that both bioflavonoids significantly increase the physical work capacity of animals and prevent from the development of physical overstrain syndrome.

[Using carnosine and natural antioxidants for the prophylaxis of acute post-loading oxidative stress].

The effects of a submaximum single physical load with a mixed aerobic-anaerobic character (combined rowing test) on the intensity of lipid peroxidation (LPO) processes, antioxidant state of the organism, and rheological properties of blood have been studied in a group of athletes. The administration of natural antioxidants significantly decreased the LPO stress induced by the physical load, reduced the suppression of the antioxidant system of the organism, and normalized the LPO-disturbed hemorheological parameters. Antioxidants such as carnosine, cytamine, and apilac can be used as non-doping means for the accelerated recovery and increase in the physical work capacity in athletes.

[Effect of carnosine and its combination with essentiale on lipid peroxidation and work capacity of experimental animals].

The effects of carnosine and its combination with essentiale on the processes of lipid peroxidation (LPO) and on the work capacity have been studied in mice. The administration of camosine, essentiale, and vitamin E, increased the work capacity of laboratory mice to a different extent, the effect being most pronounced for a mixture of carnosine and essentiale. Carnosine in the dose range studied exhibited a pronounced antioxidant effect with respect to LPO and optimized the potential of the organism in the course of intensive physical activity. This drug is not a doping and can be recommended as a means of improvement of the physical capacity.

[The effects of cytamines and their combinations with ecdystene, apilak, vitamax, and essentiale on the work capability of athletes]. / Vliianie tsitaminov i ikh kombinatsii s ékdistenom, apilakom, vitamaksom i éssentsiale na rabotosposobnost' sportsmenov.

Cytamines (hepatamin, epifamin, and suprenamin) administered in various combinations increase the working ability of high-rank athletes in experiments. These cytamines also potentiate the effects of apilak, ecdystene, vitamax, and essentiale preparations on the exercise tolerance.

[Comparative study of anabolizing activity of apilac and methandrostenolone on a model of isolated overload of the rat skeletal muscle]. / Sravnitel'noe izuchenie anaboliziruiushchei aktivnosti apilaka i metandrostenolona na modeli izolirovannoi peregruzki skeletnoi myshtsy goleni krys.

The anabolic activity of apilac was studied in rats in comparison to methanrdostenolone A 10-day administration of apilac (200 mg/kg) produced a pronounced anabolic effect manifested by a hypertrophy of m. soleus. Methanrdostenolone (10 mg/kg) also favored a gain in the muscle weight. The anabolic action of apilac was comparable to that of methanrdostenolone.

[A comparative study of the anabolic action of ecdysten, leveton and Prime Plus, preparations of plant origin]. / Sravnitel'noe izuchenie anaboliziruiushchego deistviia preparatov rastitel'nogo proiskhozhdeniia ékdistena, levetona i "Praim Plas".

A new class of anabolic substances includes different saponins, originated from Leuzea rhaponticum sp. The effect of these substances on the human body was studied by caliperometric measurements of body folds. All tested substances taken orally for three weeks diminished fat content under conditions of daily aerobic-anaerobic training. Ekdisten and Prime Plus (combination of ekdisten and pure protein) elevated the muscle mass. The same effect of leventon was less pronounced. We showed that all substances studied elevated the magnitude of "total work", estimated per 1 kg of body weight. Ekdisten and Prime Plus again appeared to be most efficient. The prospects of using the saponins in sport medicine are discussed.