[Sulacillin (a combination of ampicillin and sulbactam)--a new combined drug form for treatment of bacterial infections]. / Sulatsillin (sochetanie ampitsillina s sul'baktamom)--novaia kombinirovannaia lekarstvennaia forma dlia lecheniia bakterial'nykh infektsii.

The results of the cooperated clinical trial of sulacillin, a formulation including sodium ampicillin and sulbactam (2:1), are presented. The trial was carried out in different hospitals of Moscow and Smolensk. Rapid development of the favourable time course and recovery were stated in 93.7 per cent of the cases with upper and lower respiratory tract infections, urinary and biliferous tract infections, infections of the skin and soft tissues, gynecological infections and severe suppurative complications after surgical operations. Sulacillin is useful in the empirical therapy of purulent inflammatory diseases before the pathogen isolation and identification.

[Build up of a given concentration of tobramycin and sisomycin in the blood of young children by the intravenous infusion of the antibiotics according to a calculated regimen]. / Sozdanie zadannoi kontsentratsii tobramitsina i sizomitsina v krovi detei rannego vozrasta putem vnutrivennoi infuzii antibiotikov v raschetnom rezhime.

Three regimens for intravenous infusion of tobramycin and sisomicin in doses of 1.33 and 1 mg/kg, respectively were analysed theoretically with the use of the constants of a two-compartmental model characterizing the tobramycin pharmacokinetics in adults. The regimen implied administration of the antibiotics by means of a 12-hour infusion. The second regimen consisted of a jet injection of the initial dose simultaneously with the beginning of the maintenance infusion. The third regimen consisted of a rapid initial infusion followed by a slow maintenance infusion. It was shown that maintenance of the drug concentration at the required levels, i.e. 2-8 microgram/ml for tobramycin and 2-61 microgram/ml for sisomicin was most safely provided by the regimen of the subsequent infusions. This regimen was tried clinically in the treatment of 17 children aged 2 months to 2.5 years with severe forms of acute pneumonia. The rate of the 25-minute initial infusion of tobramycin was 22.2 microgram/kg . min and that of the subsequent 2.7-hour maintenance infusion was 4.85 microgram/kg . min, the total dose being 1.33 mg/kg. The rate of the 20-minute initial infusion of sisomicin was 21.7 microgram/kg . min and that of the subsequent 2.4-hour maintenance infusion was 3.88 microgram/kg . min, the total dose being 1 mg/kg. It was shown that the levels of both the antibiotics in the blood serum of the patients were within the required ranges.

[Dicloxacillin the treatment of suppurative inflammatory processes at various sites]. / Dikloksatsillin v lechenii gnoino-vospalitel'nykh protsessov razlichnoi lokalizatsii.

The efficacy of sodium dicloxacillin was studied in the treatment of pyo-inflammatory diseases, such as pneumonia, pyothorax, pulmonary abscess, osteomyelitis, burn disease, infections of the skin and soft tissues and others, caused by multiresistant staphylococci and other organisms sensitive to the antibiotic. The drug was effective both orally or parenterally. Satisfactory results were observed in more than 80 per cent of the patients (children and adults). It was well tolerated by the patients.

[Computerized automatic management of the therapy of arterial hypertension]. / Avtomaticheskoe upravlenie lecheniem arterial'noi gipertonii s pomoshch'iu EVM.

On the basis of the propositions of the theory of automatic control and regulation, the authors developed the method, algorithm, and program of automatic controlled treatment of arterial hypertension by means of computers. It was conducted in 160 patients with hypertensive disease. Treatment was accomplished with reserpine, dopegit, hemiton, combination of these agents with each other and with diuretics, and with brinerdin. The effect was good in 70.6% and satisfactory in 21.9% of cases; no effect was produced in 7.5% of cases. The studies showed that the created algorithms and program make it possible to carry out effective controlled hypotensive therapy by means of computers. With the use of the developed method it was found that the tuning coefficients, and consequently, the dosages of the drugs necessary for reducing arterial pressure and its maintenance on the desirable preset level differ with the patients and in one and the same patient on different days of the treatment. Automatic controlled hypotensive therapy employing computers may be accomplished with a single agent and, whenever necessary, with a combination of several agents.

[Clinical pharmacokinetics and the optimal intravenous ampicillin administration regimen in children]. / Klinicheskaia faramakokinetika i optimal'nyi rezhim vnutrivennogo vvedeniia ampitsillina u detei.

Nineteen children aged 3 months to 3 years were treated with ampicillin for acute pneumonia. The drug pharmacokinetics after a single intravenous administration in a dose of 25 mg/kg was studied. The data of the antibiotic pharmacokinetics in blood serum specimens collected within 3 hours after the drug injection were approximated with the use of the two-compartmental model, which proved to be more adequate than the one-compartmental model. The average period of the antibiotic half-life was 37 minutes and the value of the total clearance was 7.3 ml/min . kg. The optimal regimen for ampicillin administration, i. e. intravenous infusion of the antibiotic at a rate of 70 microgram/min . kg and its administration in a loading dose of 3.5 mg/kg was calculated with the use of the constants of the two-compartmental model. Clinical trials of the above regimen showed satisfactory conformity of the factual and calculated levels of the antibiotic in the blood serum of 7 children.