Subject(s)
Psoriasis/drug therapy , Toxoplasmosis, Ocular/diagnosis , Ustekinumab/adverse effects , Antibiotic Prophylaxis/methods , Antibodies, Monoclonal, Humanized/adverse effects , Antibodies, Monoclonal, Humanized/therapeutic use , Chorioretinitis/diagnosis , Chorioretinitis/etiology , Dermatologic Agents/administration & dosage , Dermatologic Agents/adverse effects , Dermatologic Agents/therapeutic use , Female , Fundus Oculi , Humans , Injections, Subcutaneous , Middle Aged , Recurrence , Tomography, Optical Coherence/methods , Toxoplasma/isolation & purification , Toxoplasmosis, Ocular/drug therapy , Toxoplasmosis, Ocular/etiology , Ustekinumab/administration & dosage , Ustekinumab/therapeutic useABSTRACT
Purpose To investigate the state of dark adaptation and macular blood flow in different forms of glaucoma. Methods Eighteen eyes of 18 patients with primary open-angle glaucoma, 14 eyes of 14 patients with pseudoexfoliation glaucoma, and 10 eyes of 10 patients with childhood glaucoma (CG) were examined by means of dark adaptometry, scanning-laser retinal flowmetry, and retinal tomography. Results All glaucomatous eyes had comparable optic disc excavation (one-way ANOVA, p = 0.138). Eyes with CG had significantly lower best-corrected visual acuity than the other groups (Tukey, all p < 0.0001). Macular perfusion was comparable in all three groups (one - way ANOVA, p = 0.08). The delay in rod-cone break time in the CG group was significantly higher than in the other groups (Tukey, all p < 0.0001). The scotopic sensitivity threshold in the CG group was significantly greater than in the other groups (Tukey, all p < 0.01). Conclusion This underlying dysfunction of dark adaptation may contribute, at least to some extent, to the decreased visual perception observed in patients with CG.
