ABSTRACT
It was shown experimentally that drinking mineral water as primary prophylaxis alleviates postadiation ultrastructural changes in pinealocytes.
Subject(s)
Mineral Waters/administration & dosage , Pineal Gland/ultrastructure , Radiation Injuries, Experimental/prevention & control , Animals , Male , Microscopy, Electron , Radiation Dosage , Radiation Injuries, Experimental/pathology , RatsABSTRACT
The exposure of the rat adrenals 30 days after radiation (1 Gy) to low-intensity infrared laser radiation arrests development of ultrastructural disorders in the cells of hypothalamus and parathyroid gland, enhances subcellular manifestations of adaptation and rehabilitation processes.
Subject(s)
Hypothalamus/radiation effects , Laser Therapy , Parathyroid Glands/radiation effects , Radiation Injuries, Experimental/radiotherapy , Adaptation, Physiological/radiation effects , Adrenal Glands/radiation effects , Animals , Hypothalamus/ultrastructure , Male , Microscopy, Electron , Neurons/radiation effects , Neurons/ultrastructure , Parathyroid Glands/ultrastructure , Radiation Injuries, Experimental/pathology , Rats , Time FactorsABSTRACT
Rat experiments have shown that course intake (21 days) of sulphate sodium-magnesium-calcium water with sulphate concentration 2.6 mg/l and mineralization 3.1 g/l in early postradiation period (1-2 Gy) inhibits development of dystrophic and destructive processes in spermatogenic epithelium of the testes and maintains spermatogenesis at higher level than control.
Subject(s)
Calcium Sulfate/therapeutic use , Magnesium Sulfate/therapeutic use , Mineral Waters/therapeutic use , Radiation Injuries, Experimental/rehabilitation , Spermatogenesis/drug effects , Spermatogenesis/radiation effects , Sulfates/therapeutic use , Animals , Calcium Sulfate/pharmacology , Dose-Response Relationship, Radiation , Drug Evaluation, Preclinical , Gamma Rays , Magnesium Sulfate/pharmacology , Male , Microscopy, Electron , Radiation Injuries, Experimental/pathology , Rats , Sulfates/pharmacology , Testis/drug effects , Testis/radiation effects , Testis/ultrastructureABSTRACT
The authors' experiments have shown that a course intake of sulfate mineral water after total radiation (1 and 5 Gy) can prevent and minimize dystrophic and necrobiotic changes in the liver, stimulate intracellular regeneration, reduce pathological mitoses in the small intestine. The response depended on radiation dose and time of crenotherapy start after radiation. Sulfate mineral water is also a weak radioprotector.
Subject(s)
Mineral Waters/administration & dosage , Radiation-Protective Agents/administration & dosage , Sulfates/administration & dosage , Whole-Body Irradiation/adverse effects , Administration, Oral , Animals , Drug Evaluation, Preclinical , Gamma Rays , Intestine, Small/drug effects , Intestine, Small/radiation effects , Intestine, Small/ultrastructure , Liver/drug effects , Liver/radiation effects , Liver/ultrastructure , Male , Mineral Waters/analysis , Radiation Injuries, Experimental/pathology , Radiation Injuries, Experimental/prevention & control , Radiation Injuries, Experimental/rehabilitation , Radiation-Protective Agents/analysis , Rats , Sulfates/analysis , Time FactorsABSTRACT
In experiments with 135 white breed-less male rats it was shown that the drinking mineral waters containing sulphate or silic ions promoted the postradiated rehabilitation in the liver after whole-body 5 Gy gamma-ray exposure. The decrease of the rate of lipid peroxidation in hepatocyte membranes, the increase of quantity normal cells and the decrease of quantity dystrophic and necrobiotic cells, the change of haemostasis took place. The iodine- and boron-containing mineral waters were less efficacious in these processes than the waters with sulphate and silic ions.
Subject(s)
Liver Regeneration/drug effects , Liver Regeneration/radiation effects , Liver/drug effects , Liver/radiation effects , Mineral Waters/therapeutic use , Animals , Drug Evaluation, Preclinical , Gamma Rays , Lipid Peroxidation/radiation effects , Liver/metabolism , Liver/pathology , Male , Rats , Stimulation, Chemical , Time FactorsABSTRACT
It is shown that both natural and dissolved iodine-bromine water given in courses to animals preexposed to 1 Gy gamma radiation promotes recovery of the damaged processes in the body. The therapeutic action of natural mineral water proved more beneficial because such water contains more iodine and minerals.
Subject(s)
Iodides/administration & dosage , Mineral Waters/administration & dosage , Radiation Injuries, Experimental/rehabilitation , Administration, Oral , Animals , Bromides/administration & dosage , Drug Evaluation, Preclinical , Liver/drug effects , Liver/pathology , Liver/radiation effects , Male , Radiation Injuries, Experimental/pathology , Rats , Thyroid Gland/drug effects , Thyroid Gland/pathology , Thyroid Gland/radiation effectsSubject(s)
Mineral Waters/therapeutic use , Radiation Injuries, Experimental/therapy , Regeneration , Animals , Bone Marrow/metabolism , Bone Marrow/pathology , Bone Marrow/physiopathology , Chromosome Aberrations , Intestinal Mucosa/metabolism , Intestines/pathology , Intestines/physiopathology , Lipid Peroxidation , Liver/metabolism , Liver/pathology , Liver/physiopathology , Mineral Waters/analysis , Mitosis , Radiation Injuries, Experimental/physiopathology , Radiation Tolerance , RatsABSTRACT
Hepatic structural adaptative changes at the cellular and subcellular levels were found to develop when silicon-containing waters were orally used with increases in silicon levels. There were phasic changes in the cellular bioenergy, which associated with changes in the number and extent of intercellular unions. The ultrastructures providing intracellular ion exchange are regarded as an important link in the mechanism of action of drinking natural silicon-containing waters.
Subject(s)
Liver/drug effects , Mineral Waters , Silicon/pharmacology , Administration, Oral , Animals , Intercellular Junctions/drug effects , Intercellular Junctions/ultrastructure , Liver/ultrastructure , Male , Microscopy, Electron , Mineral Waters/administration & dosage , Rats , Silicon/administration & dosage , Time FactorsABSTRACT
The changes of hepatic mitochondrial cells were studied in white male rats during internal application of boron-containing waters, having 250 mg/l concentration of boron, but different ionic-salt basis. Mitochondrial hepatocytes and hepatic boron content relationships were established. It was shown that during boron accumulation in liver (15 applications) decreasing of mitochondrial size occurred, independently, of the type of boron-containing waters. During stable boron level and particularly during its excretion from organism (24 applications, 6 days aftereffect), increase of size of mitochondria and their ellipticity, change of configuration, that depend on the type of applied waters was shown.
Subject(s)
Boron/adverse effects , Mitochondria, Liver/ultrastructure , Water Supply , Animals , Boron/administration & dosage , Boron/analysis , Liver/analysis , Liver/drug effects , Male , Mitochondria, Liver/drug effects , Models, Biological , Rats , SpectrophotometryABSTRACT
It has been established that intake of waters identical by Br concentrations (250 mg/l) but different by an ion-salt base leads to various structural changes of the thyroid at the tissue, cellular and subcellular levels. Artificial Br-containing water induces more pronounced shifts correlating with T3 and T4, blood concentrations. The ion-salt base was found essential in the mechanism of action of Br-containing water.