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1.
World Neurosurg ; 167: 62-66, 2022 Nov.
Article in English | MEDLINE | ID: mdl-36049721

ABSTRACT

BACKGROUND: Intraoperative ultrasonography (IOUS) in traumatic brain injury is a fast, easy, and low-cost technique that has been poorly investigated so far even though it could potentially answer many of the intraoperative needs of the surgeon. The aim of this study was to investigate the role of IOUS in patients undergoing surgery for traumatic acute subdural hematoma (aSDH), focusing on its influence on intraoperative surgical strategy, particularly regarding the management of intracerebral contusions (ICCs) associated with aSDH. METHODS: Data of patients who consecutively underwent surgical evacuation of traumatic aSDH with IOUS assistance at our institution from May 2017 to December 2020 were retrospectively analyzed. Patients were dichotomized into an ICC group (ICCs associated with aSDH on preoperative computed tomography scan) and no ICC group (no ICCs associated with aSDH on preoperative computed tomography scan). RESULTS: The study included 41 patients. Before aSDH evacuation, IOUS findings were similar to preoperative computed tomography data. After aSDH evacuation, IOUS detected a new-onset ICC in 13% of patients in the no ICC group and a volume increase of the known ICCs in 22% of patients in the ICC group. Therefore, IOUS made it possible to evacuate these new-onset or expanding hematomas in the same operation, changing our surgical strategy and avoiding a delayed reintervention. CONCLUSIONS: Our study suggests that IOUS in patients undergoing surgery for traumatic aSDH can promptly identify possible evolution of a primary head injury, leading to early and effective treatment.


Subject(s)
Hematoma, Subdural, Acute , Hematoma, Subdural, Intracranial , Humans , Hematoma, Subdural, Acute/diagnostic imaging , Hematoma, Subdural, Acute/surgery , Retrospective Studies , Hematoma, Subdural/surgery , Treatment Outcome , Ultrasonography
2.
Neuropathology ; 37(4): 329-334, 2017 Aug.
Article in English | MEDLINE | ID: mdl-28070930

ABSTRACT

Pituitary adenomas are benign tumors representing approximately 15-20% of intracranial neoplasms. There have been few reports of metaplastic osseous transformation and about 60 cases of neuronal metaplasia in pituitary adenoma but adipose metaplasia has not been previously described in the English literature. Here we report a case of pituitary adenoma with metaplastic adipose tissue in a 58-year-old male patient. Histologically this case fulfilled the criteria of a non-functioning pituitary adenoma, and moreover a central area of adipose tissue, made by mature adipocytes, and many tumor cells, containing fat droplet were evident. Lipomatous transformation of tumor cells in the CNS has been previously observed but, to the best of our knowledge, our case is the first pituitary adenoma with such change. The histogenesis of the adipose element in pituitary adenoma is not well understood, and could be a result of a metaplastic change or divergent differentiation from a common progenitor cell.


Subject(s)
Adenoma/pathology , Adipose Tissue/pathology , Pituitary Neoplasms/pathology , Humans , Male , Metaplasia/pathology , Middle Aged
3.
Clin Neuropathol ; 35(4): 186-93, 2016.
Article in English | MEDLINE | ID: mdl-27125869

ABSTRACT

A 54-year-old man with no remarkable past medical history was referred to our hospital for the appearance of generalized tonic clonic seizures with loss of consciousness, preceded by phosphenes at the right eye. On magnetic resonance imaging, a contrast-enhanced tumor in the left occipital lobe with peripheral edema was noted. He underwent craniotomy, and the entire mass was removed. Microscopic examination revealed infiltrative atypical astrocytes (glial fibrillary acidic protein, GFAP, positive) with discrete borders and granular cytoplasm. Ki-67 labeling index was 40%. The tumor was diagnosed as a high-grade granular cell astrocytoma (GCA). Postoperative radiotherapy combined with temozolomide was administered. GCAs are aggressive lesions and should not to be confused with localized, benign granular cell tumors or with other non neoplastic granular cell changes in the central nervous system (CNS). GCAs are rare tumors. At this time, only 63 supratentorial/ hemispheric cases, including our case, have been reported in literature.


Subject(s)
Astrocytoma/pathology , Brain Neoplasms/pathology , Granular Cell Tumor/pathology , Biomarkers, Tumor/analysis , Humans , Immunohistochemistry , Male , Middle Aged
4.
J Laparoendosc Adv Surg Tech A ; 18(2): 321-3, 2008 Apr.
Article in English | MEDLINE | ID: mdl-18373468

ABSTRACT

UNLABELLED: Blunt abdominal trauma is the most common cause of pancreatic injury in children. Laparoscopic distal pancreatectomy in a child with complete duct disruption has not been reported in the literature in children, although it has been well described in adults. METHODS: In this paper report a case of a 7-year-old male, with grade 4 pancreatic trauma, who was treated nonoperatively in the acute phase and subsequently by laparoscopic distal pancreatectomy 3 months after the trauma. DISCUSSION: Although in adults the surgical management of grade 3-4 pancreatic traumatic injury is well described, including the laparoscopic approach, no report of laparoscopic distal pancreatectomy was found in the literature. We would like to emphasize the importance of using a conservative management in the acute phase of pancreatic injury, including grade 4 injuries. After this phase, the use of the high-definition computed tomography scan and endoscopic retrograde pancreatography were fundamental. CONCLUSION: Magnification of laparoscopic technique allowed us to identify the structures much better than open surgery.


Subject(s)
Abdominal Injuries/pathology , Laparoscopy , Pancreas/injuries , Pancreatectomy , Abdominal Injuries/etiology , Bicycling/injuries , Child , Humans , Male , Pancreas/pathology , Pancreatic Ducts/injuries , Wounds, Nonpenetrating/pathology
5.
J Cardiovasc Med (Hagerstown) ; 7(8): 641-4, 2006 Aug.
Article in English | MEDLINE | ID: mdl-16858246

ABSTRACT

A case of right diaphragmatic hernia is presented associated with a complex congenital heart disease (double-outlet right ventricle, transposition of the great arteries and left isomerism) diagnosed prenatally. Despite high-frequency oscillatory ventilation plus nitric oxide and uneventful repair of the hernia, the infant died after 6 days of uncontrolled pulmonary hypertension and severe aortic coarctation that developed postnatally.


Subject(s)
Heart Defects, Congenital/diagnostic imaging , Hernia, Diaphragmatic/diagnostic imaging , Hernias, Diaphragmatic, Congenital , Diagnosis, Differential , Fatal Outcome , Female , Gestational Age , Humans , Infant, Newborn , Pregnancy , Ultrasonography, Prenatal
6.
J Pediatr Surg ; 40(4): 748-50, 2005 Apr.
Article in English | MEDLINE | ID: mdl-15852298

ABSTRACT

Large fetal neck masses can present a major challenge to securing an airway at birth, with associated risks of hypoxia, brain injury, and death. The authors report a case of a giant neck mass, diagnosed in a fetus of 28 weeks, treated through ex utero intrapartum treatment procedure to assist in securing an airway followed by excision of the mass on the day after delivery. A multidisciplinary team approach, combined with an accurate prenatal diagnosis obtained through fetal ultrasound magnetic resonance imaging examination, was the key to a successful outcome. The role of the pediatric surgeon was initially to secure the airways through a tracheostomy followed by excision of the mass when the infant's vital parameters had been stabilized.


Subject(s)
Fetus/surgery , Head and Neck Neoplasms/surgery , Lymphangioma, Cystic/surgery , Teratoma/surgery , Tracheostomy/methods , Adult , Airway Obstruction/etiology , Cesarean Section , Head and Neck Neoplasms/diagnosis , Humans , Infant, Newborn , Intubation, Intratracheal , Lymphangioma, Cystic/diagnosis , Magnetic Resonance Imaging , Male , Patient Care Team , Physician's Role , Teratoma/diagnosis , Ultrasonography, Prenatal
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