[Clinical and morphological characterizations of first detected cases of caseous pneumonia and its outcomes under conditions of current antibacterial therapy]. / Kliniko-morfologicheskaia kharakteristika vpervye vyiavlennoi kazeoznoi pnevmonii i ee iskhodov v usloviiakh sovremennoi antibakterial'noi terapii.

The paper provides a clinical and X-ray picture of first detected caseous pneumonia. It shows the potentialities of currently available antibiotic therapy used in patients with this diagnosis. At the same time closure of decay cavities and eradication of bacteria can be achieved only in 29% of cases. The major outcome of caseous pneumonia is fibrocavernous tuberculosis. Thus, surgical methods must play an important role in curing such patients. A detailed morphological characterization of surgical materials has demonstrated that active chemotherapy may result in 3 types of caseous pneumonia outcomes: acute progression, chronicity tended to progression, and the development of fibrocavernous tuberculosis. The morphological studies have provided evidence for the validity of the clinical and X-ray dynamics of the disease and for the correctness of choice of surgical policy.

[Effectiveness of a liposomal form of rifampicin in the treatment of experimental tuberculosis in mice]. / Effektivnost' liposomal'noi formy rifampitsina pri lechenii éksperimental'nogo tuberkuleza myshei.

The therapeutic effectiveness of rifampicin as a free form and a component of multilamellar phosphatidylcholine cholesterol liposomes was studied on a model of generalized tuberculosis in BALB/c mice. Rifampicin as a liposomal form was found to have no advantages over its free form. Possible mechanisms of the phenomenon and prospects for using liposomes in the chemotherapy of tuberculosis are discussed.