ABSTRACT
We describe a rare and interesting case of a basaloid squamous cell carcinoma (BSC) of the uterine cervix with metastasis in the left iliac region diagnosed by fine needle aspiration (FNA). A 54-year-old woman underwent FNA because of a mass in the left iliac region. The material was processed by conventional liquid based cytology (ThinPrep), and by the cell-block technique and diagnosis was based on the cytomorphologic and immunochemical characteristics as well as the patient's history. The cytologic diagnosis concerned a poorly differentiated squamous cell carcinoma. After a laborious search, we found out that the patient had undergone a total hysterectomy almost 15 years before. The histological diagnosis then was an "infiltrative squamous cell carcinoma of basaloid type" of the uterine cervix. Our case is of particular interest because it is a rare type of neoplasm with an unusual site of metastasis after a long disease-free period.
Subject(s)
Carcinoma, Squamous Cell/secondary , Pelvic Neoplasms/secondary , Uterine Cervical Neoplasms/pathology , Biopsy, Fine-Needle , Carcinoma, Squamous Cell/therapy , Female , Humans , Immunohistochemistry , Middle Aged , Neoplasms, Basal Cell/secondary , Neoplasms, Basal Cell/therapy , Pelvic Neoplasms/therapy , Uterine Cervical Neoplasms/therapyABSTRACT
PURPOSE OF INVESTIGATION: To evaluate mammographic changes in postmenopausal women receiving hormonal replacement therapy (HRT) with tibolone. METHODS: 83 postmenopausal women aged 45-62 received the same dose of tibolone for a period of six months to five years without interruption. The women were examined mammographically every six to 12 months during the observation period. RESULTS: There was a low incidence of breast tenderness. Also, we did not observe any significantly increased mammographic density or neoplasmatic disease of the breast. As far as dysplastic changes are concerned, no remarkable aggravation in the mammographic picture was noted. CONCLUSION: The new synthetic steroid tibolone, in contrast to conventional HRT, rarely causes breast pain. At least short-period tibolone therapy (less than 5 years) has good effects on climacteric disorders and does not cause breast changes (dysplasia or cancer). Our study is on-going.
Subject(s)
Breast/pathology , Estrogen Replacement Therapy/methods , Mammography , Norpregnenes/therapeutic use , Dose-Response Relationship, Drug , Drug Administration Schedule , Estrogen Replacement Therapy/adverse effects , Female , Follow-Up Studies , Humans , Middle Aged , Monitoring, Physiologic/methods , Postmenopause , Risk AssessmentABSTRACT
We report on a rare case of a 63-year-old male with malignant fibrous histiocytoma (MFH) metastatic to the right adrenal gland, first diagnosed with fine needle aspiration (FNA) biopsy. The cytological and immunocytochemical study indicated a malignant neoplasm of mesenchymal origin with characteristics of MFH. The patient was then operated on and the pathological and immunohistochemical findings confirmed the cytological diagnosis. FNA becomes more widely useful for the diagnosis of non-palpable masses. It is worth noting that the fluid-based thin-layer "Thin Prep" method provides the possibility to apply immunocytochemical stainings in FNA cytologic material, especially in cases where the material is inadequate.
