ABSTRACT
An installation was developed to precisely evaluate size of the extremity by measuring volume of displaced liquid. A classification of postmastectomy edema of the arm was suggested.
Subject(s)
Edema/classification , Mastectomy, Radical/adverse effects , Postoperative Complications/classification , Arm , Female , Humans , Lymphedema/classification , MethodsABSTRACT
Local UHF-hyperthermia in combined therapy of breast cancer patients as compared to preoperative radiotherapy used alone, resulted in more noticeable therapeutic changes in a tumor. This fact was established during a study of tumor pathomorphosis in 206 patients with stage II breast cancer. A degree of therapeutic tumor pathomorphosis showed good correlation with the frequency and duration of a recurrence-free period of disease. In III-IV degree of tumor pathomorphosis the use of thermoradiotherapy brought about a higher efficacy of radical therapy of breast cancer patients.
Subject(s)
Breast Neoplasms/therapy , Hyperthermia, Induced , Breast Neoplasms/pathology , Breast Neoplasms/radiotherapy , Combined Modality Therapy , Female , HumansSubject(s)
Lung Neoplasms/therapy , Adolescent , Adult , Aged , Combined Modality Therapy , Humans , Lymphatic Metastasis , Mediastinal Neoplasms/secondary , Middle Aged , Thoracic SurgeryABSTRACT
2,023 patients with breast tumors of medial and central localization (aged up to 60 years) received radical treatment at the Institute and oncological dispensaries of the Republic in 1967-1981 (extensive mastectomy after Urban-Kholdin-680; mastectomy after Halsted-1,343). Extensive mastectomy appeared to considerably improve 5-year survival results in patients with T1-3NO, 1MO tumors.
Subject(s)
Breast Neoplasms/surgery , Mastectomy/methods , Axilla , Breast Neoplasms/mortality , Breast Neoplasms/pathology , Combined Modality Therapy , Female , Follow-Up Studies , Humans , Lymphatic Metastasis , SternumABSTRACT
The long-term results of the combined therapy of 284 patients with infiltrative forms of breast cancer were correlated with the manifestations of radiation pathomorphosis in a tumor after preoperative radiation therapy at a single dose of 4 Gy, summary dose of 20 Gy. Surgical intervention was performed in 59% of the patients in the first 3 days after irradiation, in 30% of the patients in 4-9 days, in 11% in 10-20 days. The degree of radiation pathomorphosis was evaluated by the signs of disturbance of the general structure of the tumorous tissue and the structure of some cancer cells. The most significant changes in tumors were recorded 10-20 days after the termination of radiation therapy. An increase in the interval between the termination of irradiation and operation up to 20 days did not influence the long-term results of the combined therapy of patients with breast cancer. No correlation between the degree of radiation pathomorphosis and long-term results of combined therapy was revealed, therefore the qualitative determination of the degree of injury of tissue and cellular elements of a tumor cannot serve as an adequate criterion of efficacy of mean fractional radiation exposure in performing operation in the first 9 days after its completion.
Subject(s)
Breast Neoplasms/therapy , Adult , Breast Neoplasms/pathology , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Combined Modality Therapy , Female , Follow-Up Studies , Humans , Middle AgedABSTRACT
Based on an analysis of the 3- and 5-year results of the combined treatment of 865 patients with breast cancer using 4 variants of radiation exposure in the preoperative period the following aspects are discussed: 1) the conventional variant of gamma-beam therapy at summary doses of 40-45 Gy is not an optimum variant of preoperative irradiation; 2) better results are achieved with the preoperative irradiation of the affected breast and zones of regional metastasis at a single dose of 4 Gy and a summary dose of 20 Gy; 3) a marked tendency towards achieving still better results of treatment and a statistically significant decrease in the frequency of distant metastases detected in the first 2 years after treatment are noted with the use of two other variants of preoperative exposure: an increase in the doses in tumor growth zones up to the level which is equivalent to a carcinocidal dose and a short course of preoperative irradiation (20 Gy) under the conditions of local UHF-hyperthermia.
Subject(s)
Breast Neoplasms/radiotherapy , Hyperthermia, Induced , Preoperative Care , Breast Neoplasms/mortality , Breast Neoplasms/pathology , Combined Modality Therapy , Evaluation Studies as Topic , Female , Gamma Rays/therapeutic use , Humans , Neoplasm Metastasis , Neoplasm Staging , Radioisotope Teletherapy , Radiotherapy Dosage , Random AllocationABSTRACT
The report deals with a retrospective comparison of the effectiveness of standard and large-fractionated preoperative radiation therapy of breast cancer patients (each group included 85 females). As a result of distant irradiation with daily single doses of 4 Gy (total dose--20 Gy), preoperative admission period was reduced 5--7 times, as compared with standard single doses of 2 Gy and total dosage of 40--45 Gy. Large--fractionated radiation therapy results in a relatively low incidence of general and local reactions, does not interfere with surgery and is followed by postoperative complications in fewer cases. The distant metastasis frequency was significantly lower (51 +/- 5 and 32 +/- 5%, respectively), while the 5-year survival rate--higher (45 +/- 5 and 65 +/-5%, respectively) in application of large--fractionated radiation therapy. The said advantages were particularly apparent in cases of local operable tumors (stage III); in such patients, the 5-year survival rate rose from 40 +/- 7 to 64 +/- 6% (p greater than 0.05).
