1.
JAMA
; 231(12): 1248-51, 1975 Mar 24.
Article
in English
| MEDLINE
| ID: mdl-163931
ABSTRACT
In two double-blind trials, volunteers challenged with rhinovirus were treated with aspirin or placebo. Aspirin treatment did not alter the rates of infection or illness but was associated with a moderate reduction in the frequency or severity of some symptoms. The overall benefit in rhinovirus infection was not statistically significant. Aspirin treatment appeared to cause a highly significant increase in the rate of virus shedding in treated subjects. The increase in virus shedding must be considered an adverse event that could influence the course of the disease in the individual and increase the likelihood of the spread of the infection to contacts.
Subject(s)
Aspirin/adverse effects , Common Cold/microbiology , Rhinovirus/isolation & purification , Adult , Animals , Antibodies, Viral/analysis , Aspirin/pharmacology , Aspirin/therapeutic use , Clinical Trials as Topic , Common Cold/drug therapy , Common Cold/transmission , Guinea Pigs/immunology , Humans , Informed Consent , Nasal Mucosa/metabolism , Neutralization Tests , Placebos , Rhinovirus/drug effects , Rhinovirus/immunology , Time Factors , Virus Replication
2.
N Engl J Med
; 291(2): 57-61, 1974 07 11.
Article
in English
| MEDLINE
| ID: mdl-4365144
Subject(s)
Common Cold/prevention & control , Interferon Inducers , Propylamines/administration & dosage , Rhinovirus , Administration, Topical , Antibodies, Viral/analysis , Clinical Trials as Topic , Common Cold/immunology , Common Cold/microbiology , Cytopathogenic Effect, Viral , Diamines/administration & dosage , Diamines/therapeutic use , Ethanol/administration & dosage , Ethanol/therapeutic use , Humans , Interferons/analysis , Nasal Mucosa/metabolism , Neutralization Tests , Nose , Placebos , Propylamines/therapeutic use , Rhinovirus/immunology , Rhinovirus/isolation & purification , Rhinovirus/pathogenicity , Time Factors , Virus Cultivation
3.
Proc Inst Med Chic
; 30(2): 70, 1974.
Article
in English
| MEDLINE
| ID: mdl-4602787