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1.
Adv Pediatr ; 70(1): 131-144, 2023 08.
Article in English | MEDLINE | ID: mdl-37422291

ABSTRACT

Lower urinary tract obstruction (LUTO) is a rare birth defect with a prevalence between 1 in 5,000 and 1 in 25,000 pregnancies. LUTO is one of the most common causes of congenital abnormalities of the renal tract. Several genetic conditions have been associated with LUTO. Most common causes of LUTO are posterior urethral valves and urethral atresia. Despite available prenatal and postnatal treatments, LUTO is a significant cause of morbidity and mortality in newborns causing significant end stage renal disease and pulmonary hypoplasia.


Subject(s)
Urethral Obstruction , Urinary Tract , Pregnancy , Female , Humans , Infant, Newborn , Retrospective Studies , Ultrasonography, Prenatal , Urethral Obstruction/diagnosis , Urethral Obstruction/epidemiology , Urethral Obstruction/etiology , Kidney , Urinary Tract/abnormalities
3.
Adv Pediatr ; 69(1): 123-132, 2022 08.
Article in English | MEDLINE | ID: mdl-35985704

ABSTRACT

Chronic kidney disease (CKD) in children has a significant impact on morbidity, mortality, and quality of life. The degree of renal dysfunction should be calculated using pediatric-specific formulas and the degree of CKD staged; this allows for appropriate dosing of medications based on renal function and monitoring for progression and comorbid conditions including metabolic acidosis, bone disease, anemia, cardiovascular complications, malnutrition and electrolyte abnormalities, growth failure, and psychosocial issues. Treatment strategies include treating the underlying disease and using general renal protective measures. Effective management of these complex issues requires a specialized multidisciplinary team approach.


Subject(s)
Acidosis , Anemia , Renal Insufficiency, Chronic , Acidosis/complications , Anemia/diagnosis , Anemia/etiology , Anemia/therapy , Child , Humans , Kidney , Quality of Life , Renal Insufficiency, Chronic/complications , Renal Insufficiency, Chronic/diagnosis , Renal Insufficiency, Chronic/therapy
5.
Fetal Pediatr Pathol ; 26(3): 119-24, 2007.
Article in English | MEDLINE | ID: mdl-17886022

ABSTRACT

Anemia and cough are common problems with adolescent females. We present a case where these common symptoms led to the discovery of an uncommon entity, Goodpasture's Syndrome. The purpose of this report is to review the clinical manifestations, treatment and pathology of Goodpasture's Syndrome.


Subject(s)
Acute Kidney Injury/etiology , Anemia/etiology , Anti-Glomerular Basement Membrane Disease/diagnosis , Cough/etiology , Adolescent , Adult , Anti-Glomerular Basement Membrane Disease/complications , Anti-Glomerular Basement Membrane Disease/pathology , Anti-Glomerular Basement Membrane Disease/therapy , Child , Female , Humans
6.
Pediatr Nephrol ; 19(3): 317-21, 2004 Mar.
Article in English | MEDLINE | ID: mdl-14714171

ABSTRACT

The hemolytic uremic syndrome (HUS) is most commonly associated with Escherichia coli, but has been associated with other infections such as Streptococcus pneumoniae. Pneumococcus-induced HUS carries an increased risk of mortality and renal morbidity compared with E. coli-induced HUS. The pneumococcal organism produces an enzyme, which can expose an antigen (T-antigen) present on erythrocytes, platelets, and glomeruli. Antibodies to the T-antigen, normally found in human serum, bind the exposed T-antigen, and the resultant antigen-antibody reaction (T-activation) can lead to HUS and anemia. Clinicians need to be aware to request specific testing when pneumococcus-induced HUS/anemia is suspected, as current blood banking techniques do not routinely test for the presence of the T-antigen. Once this association is documented, washing all blood products and avoiding plasma products, if possible, is recommended. Plasmapheresis can be considered for the more critically ill patient. The incidence of pneumococcus-induced HUS may be increasing. We report six cases of pneumococcus-induced HUS/anemia presenting at our hospital.


Subject(s)
Hemolytic-Uremic Syndrome/immunology , Hemolytic-Uremic Syndrome/microbiology , Pneumococcal Infections/complications , Pneumococcal Infections/immunology , Streptococcus pneumoniae , T-Lymphocytes/immunology , Anemia/immunology , Anemia/microbiology , Child, Preschool , Humans , Infant , Lymphocyte Activation
7.
Clin Pediatr (Phila) ; 42(7): 627-34, 2003 Sep.
Article in English | MEDLINE | ID: mdl-14552522

ABSTRACT

The objective of this study was to determine rates of blood pressure (BP) screening at well-child visits as recommended by the Task Force on Blood Pressure Control in Children. The 1985 and 1996 National Ambulatory Medical Care Surveys were analyzed for changes in proportion of well visits for children aged 3-18 years at which BP was checked. Patient and physician demographics are described. BP screening increased from 50% in 1985 to 61% in 1996. For pediatricians, the estimates were 50% (95% CI, 43-57) and 60% (95% CI, 53-68). For family/general medicine the estimates were 51% (95% CI, 34-69) and 58% (95% CI, 43-74). Age, geographic location, and length of a visit were significant in predicting BP screening. Gender, race, ethnicity, or urban location were not. A stepwise logistic regression confirmed these results. Rates of screening BP at well-child visits have increased but fall short of current recommendations. High-risk children are not screened at a rate different from their lower risk peers.


Subject(s)
Blood Pressure , Office Visits , Adolescent , Blood Pressure Determination , Child , Child, Preschool , Female , Humans , Logistic Models , Male , Mass Screening , Practice Patterns, Physicians'
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