ABSTRACT
A solution of clindamycin in 50 percent alcohol used topically in the treatment of acne was found to be an adequate therapy to replace systemic tetracycline. Patients followed over a two to three month period showed improvement in lesion counts and subjective improvement as evaluated by the investigator and patient.
Subject(s)
Acne Vulgaris/drug therapy , Clindamycin/therapeutic use , Administration, Topical , Adolescent , Adult , Child , Female , Humans , MaleABSTRACT
Neomycin ointment is shown to be no more effective than placebo ointment in preventing site infection after biopsy according to a double-blind, placebo controlled study, analyzed according to an armitage restricted design, two-sided test, sequential analysis.
Subject(s)
Biopsy/adverse effects , Neomycin/therapeutic use , Skin Diseases, Infectious/prevention & control , Adult , Aged , Clinical Trials as Topic , Double-Blind Method , Female , Humans , Male , Middle Aged , Ointments , PlacebosABSTRACT
Tetracycline was compared to clindamycin as adjunctive therapy in the treatment of moderate to moderately severe acne under double-blind controlled conditions. Both antibiotics were efficacious and differences were not appreciable. Lesion counts of both comedones and pustules were reduced and clinical improvement was noted in the majority of subjects. Side effects were not a problem. The place of clindamycin in the therapeutic armamentarium of the dermatologist is discussed.
Subject(s)
Acne Vulgaris/drug therapy , Clindamycin/therapeutic use , Tetracycline/therapeutic use , Adolescent , Clindamycin/administration & dosage , Clinical Trials as Topic , Drug Evaluation , Female , Humans , Male , Tetracycline/administration & dosageABSTRACT
The progeny of mothers treated with lincomycin during the first, second, or third trimester of their pregnancy were extensively evaluated at various periods extending to 7 years after birth. As compared to a control group (mothers not receiving lincomycin), the study group did not show any more developmental anomalies of the teeth, specific physical defects, general developmental anomalties, or late developing abnormalities in speech, emotional and mental make-up, or ability to adjust to schooling, than would occur in the normal population. The relationship to clindamycin, a closely related derivative, and to antibiotic therapy during pregnancy is discussed.
