The First Case of Huntington's Disease like 2 in Mali, West Africa.

Background: Huntington's disease like 2 (HDL2) has been reported exclusively in patients with African ancestry, mostly originating from South Africa. Case report: We report three patients in Mali including a proband and his two children who have been examined by neurologists and psychiatrists after giving consent. They were aged between 28 and 56 years old. Psychiatric symptoms were predominant in the two younger patients while the father presented mainly with motor symptoms. Genetic testing identified a heterozygous 40 CTG repeat expansion in the Junctophilin-3 (JPH3) gene in all three patients. Discussion: This study supports the hypothesis that HDL2 may be widely spread across Africa. Highlights: We report here the first case of HDL2 in West Africa, suggesting that HDL2 is widely spread across African continent, and increasing access to genetic testing could uncover other cases.

[Management of addictions at the University Hospital Center Point G, Bamako-Mali]. / Prise en charge des addictions au Centre Hospitalier Universitaire du Point G, Bamako-Mali.

OBJECTIVE: To evaluate the health impact of drug use among patients in care in the psychiatric unit of the University Hospital Center Point G. METHOD: This was a prospect in description study of drug users admitted to the G-UHC for care. From January to July 2018. It was performed in the Psychiatry Department of the University Hospital Center Point G in Bamako, which is the only structure in Mali that deals with addiction. RESULTS: Our results show that young people in the 20-30 year group were the most affected. Cannabis was the most consumed, followed by Alcohol, and Tramadol Hydrochloride. There were cases of poly-drug abuse as well as new forms of consumption. Drug use has multiple negative consequences on health and social life: addiction, psychopathological disorders. CONCLUSION: Substance abuse of drugs is a reality that is gaining momentum in Mali. Our study have demonstrated its sanitary impact among patients with adduction. The fight against the use of drugs requires the combined efforts of all the actors involved.

OBJECTIF: Evaluer l'impact sanitaire de la consommation des drogues chez les patients pris en charge au service de psychiatrie du Centre Hospitalier universitaire du Point G. MÉTHODE: Il s'agissait d'une étude prospective descriptive chez les patients consommateurs de drogues admis au CHU du Point G pour des soins. Elle a été réalisée de janvier à juillet 2018. Elle a été réalisée dans le service de Psychiatrie du Centre Hospitalier Universitaire du Point G à Bamako, Mali, l'unique structure au Mali qui fait la prise en charge de l'addiction. RÉSULTATS: Nos résultats ont montré que les jeunes de la tranche 20-30 ans étaient les plus touchés. Le Cannabis était le plus consommé, suivi la de l'Alcool, et du Chlorhydrate de Tramadol. La polytoxicomanie ainsi que des nouvelles formes de consommation avait été notée. La consommation de drogues avait généré de multiples conséquences néfastes sur la santé et la vie sociale : la dépendance, les troubles psychopathologiques. CONCLUSION: L'abus de substances psychoactives, est une réalité qui prend de l'ampleur au Mali. Notre étude a démontré son impact sur la santé des consommateurs. La lutte contre l'usage des drogues nécessite la conjugaison des efforts de tous les acteurs impliqués.