Subject(s)
Adenocarcinoma/secondary , Muscle Neoplasms/secondary , Stomach Neoplasms/pathology , Adenocarcinoma/diagnosis , Adenocarcinoma/surgery , Biopsy , Diagnosis, Differential , Gastrectomy , Humans , Leg , Magnetic Resonance Imaging , Male , Muscle Neoplasms/diagnosis , Neoplasm Staging , Stomach Neoplasms/surgeryABSTRACT
OBJECTIVE: To examine the effect of intra-articular injection of contrast media, sorbitol and normal saline on the synovial membrane. MATERIALS AND METHODS: Sixty three rabbits (126 knees) were used in this study. We injected the knees with amidotrizoate, ioxaglate, iopamidol, iotrol and diluted gadolinium-DTPA (2 mmol/l). Normal saline and sorbitol 27.25% were used for comparison. A histological and histochemical examination of the knees was carried out 1, 2, 10, 20, 30, 40 and 60 days after the injection. RESULTS: On histological examination, the knees injected with normal saline, ioxaglate and gadolinium-DTPA had a normal appearance. Intra-articular injection of amidotrizoate, iopamidol, iotrol and sorbitol caused early, mild and transient histological changes of the synovium (synovial hyperplasia, infiltration by leucocytes). Furthermore, the knees injected with amidotrizoate presented with late, extensive histological changes (severe synovial hyperplasia, moderate vascular dilatation, severe infiltration by leukocytes). CONCLUSION: The results suggest that the chemical structure and not the osmolality of the contrast media is the main cause for the histological changes of the synovium.
Subject(s)
Contrast Media/pharmacology , Knee Joint , Synovial Membrane/drug effects , Animals , Arthrography , Diatrizoate/pharmacology , Fluoroscopy , Gadolinium DTPA/pharmacology , Injections, Intra-Articular , Iopamidol/pharmacology , Ioxaglic Acid/pharmacology , Rabbits , Triiodobenzoic Acids/pharmacologyABSTRACT
Noncompaction of the ventricular myocardium is a rare congenital cardiomyopathy, which appears to represent an arrest in intrauterine endomyocardial morphogenesis. It is diagnosed both in children and adults. Its common presentation involves heart failure symptoms, ventricular tachyarrhythmias and thromboembolic events, but the age of onset varies widely. The diagnosis is made by the combined appearance of numerous, excessively prominent trabeculations and multiple deep intertrabecular recesses perfused from the ventricular cavity, commonly involving the apical and midventricular segments of the left ventricle. Although the peculiar echocardiographic picture may possibly lead to the correct diagnosis, this condition may be often misdiagnosed or unrecognized since it is not widely known.
