ABSTRACT
Small cell carcinoma either primary or metastatic is an uncommon malignancy in the oral and perioral tissues. We are reporting such a case.
Subject(s)
Carcinoma, Small Cell/secondary , Mandibular Neoplasms/secondary , Carcinoma, Small Cell/pathology , Fractures, Spontaneous/pathology , Humans , Lung Neoplasms/pathology , Male , Mandibular Fractures/pathology , Mandibular Neoplasms/pathology , Middle AgedABSTRACT
Malignant tumors of the temporal bone are rare neoplasms. Adenoid cystic carcinoma (ACC) is the most common malignant tumor of minor salivary glands, while a quite rare tumor of the major. It is considered a slow-growing tumor with a course that is characterized by local recurrences and late distant metastases to lungs (80-90%), bone and liver. When metastases occur in bone especially the spine, the course of disease is usually fulminant. Intracranial involvement can occur by direct extension, hematogenous or perineural spread and represents an advanced stage of the disease. In this paper, we present a rare case of temporal bone ACC reporting for the first time simultaneous bony and pulmonary distant metastases. The origin, the pathology, the imaging techniques, the differential diagnosis, the treatment options and the prognosis of these tumors are discussed.
Subject(s)
Carcinoma, Adenoid Cystic/diagnostic imaging , Carcinoma, Adenoid Cystic/secondary , Skull Neoplasms/diagnostic imaging , Skull Neoplasms/pathology , Temporal Bone/diagnostic imaging , Temporal Bone/pathology , Aged , Aged, 80 and over , Humans , Male , Tomography, X-Ray ComputedABSTRACT
Explants from seeds of Silybum marianum were used to produce either transformed ('hairy') or untransformed root cultures. Silybin, isosilybin, silychristin and silydianin were found in untransformed root cultures, by means of TLC and HPLC. In contrast, only isosilybin and traces of silychristin and silydianin were identified in the 'hairy' root cultures.
Subject(s)
Asteraceae , Plants, Medicinal , Cell Culture Techniques , Chromatography, High Pressure Liquid , Chromatography, Thin Layer , Humans , Lignans/chemistry , Plant Extracts/chemistry , Plant RootsABSTRACT
Angiosarcomas are rapidly growing malignant neoplasms arising from the vascular endothelial cells. Most common sites are the extremities and the retroperitoneal space, with only four per cent of angiosarcomas arising in the head and neck area, whilst the paranasal sinuses are one of the rarest locations. We report the case of a maxillary sinus angiosarcoma in a 72-year-old male patient. The first biopsy was inconclusive, whereas the second revealed an angiosarcoma. Medial maxillectomy was performed with subsequent external irradiation.
Subject(s)
Hemangiosarcoma/diagnostic imaging , Hemangiosarcoma/surgery , Maxillary Sinus Neoplasms/diagnostic imaging , Maxillary Sinus Neoplasms/surgery , Maxillary Sinus/diagnostic imaging , Maxillary Sinus/surgery , Aged , Humans , Male , Tomography, X-Ray ComputedABSTRACT
The fate of leucine nitrogen in the central nervous system was investigated by incubating rat cerebral cortex slices in the presence of 0.5 mM each of L-[15N]-leucine, L-isoleucine, and L-valine. Analysis of the slices and incubation media for free amino acids by gas chromatography-mass spectrometry revealed that the 15N from leucine is incorporated into isoleucine only. No 15N was detected in valine or any other amino acid. These results suggest that leucine, valine, and their corresponding aminotransferases may be compartmentalized in brain cerebral cortex.
Subject(s)
Cerebral Cortex/metabolism , Isoleucine/metabolism , Leucine/metabolism , Amino Acids/isolation & purification , Amino Acids/metabolism , Animals , Chromatography, Gas , Gas Chromatography-Mass Spectrometry , In Vitro Techniques , Isoleucine/isolation & purification , Isotope Labeling/methods , Male , Nitrogen Isotopes , Rats , Rats, WistarABSTRACT
The serum vitamin E levels of 11 full-term and 10 premature infants, jaundiced and subjected to phototherapy, were measured and compared wth 9 premature and 10 full-term jaundiced control infants. No differences were observed before or after phototherapy or 1 week after stopping it. The same negative results were noted in the two groups of infants regarding the values of microhematocrit, Hb and reticulocytes.
