ABSTRACT
Squamous cell carcinoma (SCC) developing in lesions of discoid lupus erythematosus (DLE) is rare, most frequently arising on sun-exposed skin and very rarely affecting the lips. A review of the English language literature revealed only 21 published cases of labial SCC in patients with DLE. Here, an unusual case of a patient with DLE who developed 3 primary SCCs of the oral and perioral region is presented. A 40-year-old female with a 24-year history of DLE with peri- and intraoral involvement initially developed SCC of the vermillion border of the right lower lip; the lesion was surgically removed and did not recur within 6 months. In spite of strong recommendation for regular follow-up, the patient failed to keep her appointments but returned 7 years later. No signs of recurrence of the original lower lip cancer were noticed, but a new SCC of the left lateral border of the tongue with cervical lymph node metastasis was diagnosed; despite aggressive combined treatment, locoregional recurrence and distant metastatic disease developed within a few months; in addition, a new primary SCC of the vermillion border of the left lower lip developed. This rare case and a thorough review of the pertinent literature underscore the possibility of development of even multiple intraoral and perioral SCCs in the context of longstanding DLE, which necessitates close long term follow-up for early diagnosis and management.
Subject(s)
Carcinoma, Squamous Cell/pathology , Lip Neoplasms/pathology , Lupus Erythematosus, Discoid/pathology , Neoplasms, Multiple Primary/pathology , Tongue Neoplasms/pathology , Adult , Fatal Outcome , Female , HumansABSTRACT
Werner syndrome, also called progeria of the adult and pangeria is a rare autosomal recessive disorder that affects connective tissue throughout the body. It is associated with premature ageing and an increased risk of cancer and other diseases. The mean survival for patients with Werner syndrome is 47 years. Death usually occurs when patients are aged 30-65 years because of atherosclerosis or malignant tumours. The purpose of this paper is to present a patient with Werner syndrome exhibiting a chondrosarcoma of the left temporomandibular joint and ramus. To the best of our knowledge this is the first case, of a Werner syndrome patient with an associated head and neck chondrosarcoma being reported. The diagnostic procedure followed and management of the patient are outlined in the paper as well.
Subject(s)
Chondrosarcoma/diagnosis , Mandibular Condyle/pathology , Mandibular Neoplasms/diagnosis , Temporomandibular Joint Disorders/diagnosis , Werner Syndrome/complications , Biopsy/methods , Biopsy, Fine-Needle/methods , Follow-Up Studies , Humans , Male , Radiography, Panoramic/methods , Tomography, X-Ray Computed/methods , Young AdultABSTRACT
BACKGROUND: Pleomorphic adenoma is the most common neoplasm of the parotid gland. It is a benign tumor composed of epithelial and myoepithelial cells arranged in various morphological patterns. The most common reasons contributing to a recurrent disease are obvious or underestimated tumor spillage, incomplete excision, and violation of the pseudocapsule of the tumor. CASE REPORT: This article presents a case of gross multinodular recurrence of a parotid gland pleomorphic adenoma in a 38-year-old female patient. Upon clinical examination of the homolateral neck, multiple, painless, well-defined, palpable, nontender masses and subcutaneous nodules of the right parotid and homolateral neck region were revealed. The patient was treated with surgery and subsequent radiation therapy. Histologic examination of the resected specimen was suggestive of a recurrent pleomorphic adenoma disease. There were no signs of malignant transformation in the specimen. The diagnostic procedure followed, and management of the patient is outlined in the paper. DISCUSSION: Pleomorphic adenoma is the most common tumor of the parotid gland. In spite of being a benign neoplasm, inadequate management of the lesion may lead to problems such as local recurrence or malignant transformation. Management of recurrent tumors is challenging because the probability of subsequent recurrence increases with each recurrent episode, thus making local control increasingly difficult and damage to the facial nerve more likely.
Subject(s)
Adenoma, Pleomorphic/diagnosis , Head and Neck Neoplasms/diagnosis , Neoplasm Recurrence, Local/diagnosis , Neoplasms, Multiple Primary/diagnosis , Parotid Neoplasms/diagnosis , Adenoma, Pleomorphic/pathology , Adenoma, Pleomorphic/radiotherapy , Adenoma, Pleomorphic/surgery , Adult , Biopsy, Fine-Needle , Combined Modality Therapy , Female , Head and Neck Neoplasms/pathology , Head and Neck Neoplasms/radiotherapy , Head and Neck Neoplasms/surgery , Humans , Magnetic Resonance Imaging , Neck Dissection , Neoplasm Recurrence, Local/pathology , Neoplasm Recurrence, Local/radiotherapy , Neoplasm Recurrence, Local/surgery , Neoplasms, Multiple Primary/pathology , Neoplasms, Multiple Primary/radiotherapy , Neoplasms, Multiple Primary/surgery , Parotid Gland/pathology , Parotid Gland/surgery , Parotid Neoplasms/pathology , Parotid Neoplasms/radiotherapy , Parotid Neoplasms/surgery , Radiotherapy, AdjuvantABSTRACT
INTRODUCTION: Sublingual salivary gland neoplasms are extremely rare, accounting for only 0.3-1% of all epithelial salivary gland tumors. Most of the sublingual tumors are malignant, adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC) being the most common histological types. The coexistence of two salivary gland tumors located in different major salivary glands is uncommon. CASE REPORT: A rare case of two simultaneous tumors of the major salivary glands, one in the sublingual and the other in the contralateral parotid gland in a female patient is reported. DISCUSSION: The diagnostic procedure followed, and the management of the patient, is outlined in the paper.
Subject(s)
Adenoma, Pleomorphic/pathology , Carcinoma, Adenoid Cystic/pathology , Neoplasms, Multiple Primary/pathology , Parotid Neoplasms/pathology , Sublingual Gland Neoplasms/pathology , Adenoma, Pleomorphic/surgery , Carcinoma, Adenoid Cystic/surgery , Female , Humans , Lingual Nerve/surgery , Magnetic Resonance Imaging , Middle Aged , Neoplasms, Multiple Primary/surgery , Parotid Neoplasms/surgery , Sublingual Gland Neoplasms/surgeryABSTRACT
INTRODUCTION: Dermoid cysts of the floor of the mouth and submandibular space represent an unusual clinical entity. CASE REPORT: A case of an enlarged median dermoid cyst in a young female adult causing obstruction of the airway is reported. DISCUSSION: The need of an extraoral and intraoral incision for the removal of the cyst is discussed, along with a review of the literature.
