1.
Vaccine
; 23(46-47): 5289-93, 2005 Nov 16.
Article
in English
| MEDLINE
| ID: mdl-16054732
ABSTRACT
A 7-valent CRM197 conjugate pneumococcal vaccine (PCV)-induced immune response were evaluated in all Greek symptomatic HIV-1 infected children and 21 age-matched controls. PCV immunogenicity was inferior in HIV patients compared with the controls although differences in geometric mean concentrations (GMC) were not significant (P>.05). Immune responses were strikingly different after anamnestic immunization, given in all study subjects, 12 months later. HIV-positive children achieved lower GMC for all serotypes compared with the controls (P=.002) and avidity for all except serotype 6B was inferior compared to baseline. Long-term PCV effectiveness is expected to be reduced among symptomatic HIV-1 infected children.
Subject(s)
HIV Infections/immunology , HIV-1 , Immunologic Memory/immunology , Pneumococcal Vaccines/immunology , Antibodies, Bacterial/analysis , Antibodies, Bacterial/biosynthesis , Antibody Affinity , Child , Female , Greece , Humans , Immunization Schedule , Immunoglobulin G/analysis , Immunoglobulin G/biosynthesis , Kinetics , Male , Vaccines, Conjugate/immunology
2.
AIDS
; 17(9): 1396-8, 2003 Jun 13.
Article
in English
| MEDLINE
| ID: mdl-12799564