ABSTRACT
Forty-five patients with acute or recurrent pyelonephritis (32), lower respiratory infection (7) or various other serious infections (6), were treated with ceftazidime. Most infections were severe, often in the presence of aggravating factors, and had failed to respond to previous antibiotic therapy. Infecting organisms were Escherichia coli (23), other Enterobacteriaceae (5), Pseudomonas aeruginosa (11), mixed flora including Ps. aeruginosa (3) and Staphylococcus albus (1). The organisms were often multiresistant. Dosage ranged from 1 to 6 g daily im or iv. All patients were clinically cured, except two who only improved. In 35 patients the organisms were eradicated, in two partially eradicated, and in six persisted or recurred. Most bacteriological failures were observed in patients infected with Ps. aeruginosa. Tolerance of the drug was excellent. A transient leucopenia was observed in one patient and transient high SGOT and LDH in another. After an intramuscular dose of 1 g im serum levels were 33 mg/l at 2 h, 137 mg/l at 6 h and 85 mg/l at 12 h. The average half-life was 2.6 h. Urinary levels were high and 79-92% of the dose was recovered from the urine after 12 h. After 3 days therapy with 1 and 2 g im 12-hourly, bone levels exceeded 10 and 15 mg/l, respectively. Ceftazidime was a safe and effective drug for the treatment of infection. A dose of 0.5 g 12-hourly is sufficient for urinary infections, but higher doses are needed in other infections, especially when due to Ps. aeruginosa.
Subject(s)
Anti-Bacterial Agents/pharmacokinetics , Anti-Bacterial Agents/therapeutic use , Bacterial Infections/drug therapy , Ceftazidime/pharmacokinetics , Ceftazidime/therapeutic use , Adult , Aged , Anti-Bacterial Agents/adverse effects , Bacterial Infections/microbiology , Biological Assay , Bone and Bones/metabolism , Ceftazidime/adverse effects , Drug Resistance, Multiple, Bacterial , Female , Half-Life , Humans , Male , Middle Aged , Treatment Outcome , Young AdultABSTRACT
A number of joints suffering from haemophilic arthropathy was studied. They were surveyed clinically, radiologically, and with a new system of whole-body gamma-camera scintigraphy. This radio-isotopic technique provides advantages such as sensitivity, speed and safety. The results of the survey are presented and discussed.
Subject(s)
Hemophilia A/complications , Joint Diseases/diagnosis , Radionuclide Imaging , Whole-Body Counting , Adolescent , Adult , Child , Child, Preschool , Hemarthrosis/diagnosis , Hemarthrosis/etiology , Hemophilia B/complications , Humans , Joint Diseases/diagnostic imaging , Joint Diseases/etiology , Middle Aged , Radiography , Radionuclide Imaging/instrumentation , Whole-Body Counting/instrumentationABSTRACT
A study was made of 43 patients (48 hips) operated for diseases of the hip using Girdlestone's method. The follow-up time ranged from 2.5 to 13 years. For assessment of the post-operative results the following parameters were taken into consideration: pain, range of movement, gait and the patient's opinion. These were studied separately and in relation to the type of disease, the patient's age, and the time which had elapsed since the operation. Pain decreased in a considerable number of patients and range of movement and gait improved. The patients were generally in favor of the operation, and felt it had had a beneficial effect on their condition.
