Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Hum Exp Toxicol ; 35(9): 958-65, 2016 Sep.
Article in English | MEDLINE | ID: mdl-26500220

ABSTRACT

Vigabatrin (VGB) is an antiepileptic drug thatincreases brain γ-aminobutyric acid (GABA) levels through irreversible inhibition of GABA transaminase. The aim of this study was to evaluate neurotoxicological effects of VGB measuring motor activity and genotoxic and mutagenic effects after a single and repeated administration. Male Wistar rats received saline, VGB 50, 100, or 250 mg/kg by gavage for acute and subchronic (14 days) treatments and evaluated in the rotarod task. Genotoxicity was evaluated using the alkaline version of the comet assay in samples of blood, liver, hippocampus, and brain cortex after both treatments. Mutagenicity was evaluated using the micronucleus test in bone marrow of the same animals that received subchronic treatment. The groups treated with VGB showed similar performance in rotarod compared with the saline group. Regarding the acute treatment, it was observed that only higher VGB doses induced DNA damage in blood and hippocampus. After the subchronic treatment, VGB did not show genotoxic or mutagenic effects. In brief, VGB did not impair motor activities in rats after acute and subchronic treatments. It showed a repairable genotoxic potential in the central nervous system since genotoxicity was observed in the acute treatment group.


Subject(s)
4-Aminobutyrate Transaminase/antagonists & inhibitors , Anticonvulsants/toxicity , DNA Damage , Micronuclei, Chromosome-Defective/chemically induced , Vigabatrin/toxicity , Animals , Cerebral Cortex/drug effects , Cerebral Cortex/enzymology , Cerebral Cortex/pathology , Comet Assay , Dose-Response Relationship, Drug , Hippocampus/drug effects , Hippocampus/enzymology , Hippocampus/pathology , Liver/drug effects , Liver/enzymology , Liver/pathology , Male , Micronucleus Tests , Motor Activity/drug effects , Organ Specificity , Rats, Wistar , Rotarod Performance Test , Time Factors
SELECTION OF CITATIONS
SEARCH DETAIL
...