ABSTRACT
Primary central nervous system lymphoma is one of the most infrequent brain tumours, accounting for 3% of primary central nervous system neoplasms. In addition to its low prevalence, clinical presentation is usually nonspecific, leading to diagnostic delay. Intraocular involvement occurs in 15% of cases, and disease onset in this location is even rarer. We present a case of a patient with intermediate uveitis as the first clinical manifestation of this neoplasm.
Subject(s)
Brain Neoplasms , Lymphoma , Uveitis , Brain Neoplasms/diagnostic imaging , Central Nervous System/pathology , Delayed Diagnosis , Humans , Lymphoma/diagnostic imaging , Uveitis/diagnosisABSTRACT
El linfoma primario del sistema nervioso central (LPSNC) es una de las neoplasias cerebrales más infrecuentes, representando el 3% de los tumores primarios en dicha localización. Sumado a su baja prevalencia, las manifestaciones clínicas de esta patología son poco específicas, por lo que es común el retraso diagnóstico de esta entidad. El compromiso intraocular relacionado al LPSNC ocurre sólo en un 15% de los casos, siendo aún más inusual que dicha topografía se presente como debut en esta enfermedad. Presentamos el caso clínico de una paciente con uveítis intermedia como primera manifestación clínica de esta neoplasia (AU)
Primary central nervous system lymphoma is one of the most infrequent brain tumours, accounting for 3% of primary central nervous system neoplasms. In addition to its low prevalence, clinical presentation is usually nonspecific, leading to diagnostic delay. Intraocular involvement occurs in 15% of cases, and disease onset in this location is even rarer. We present a case of a patient with intermediate uveitis as the first clinical manifestation of this neoplasm (AU)
Subject(s)
Humans , Female , Middle Aged , Central Nervous System Neoplasms/complications , Central Nervous System Neoplasms/diagnostic imaging , Uveitis, Intermediate/diagnostic imaging , Uveitis, Intermediate/etiology , Lymphoma/diagnostic imaging , Lymphoma/complications , Tomography, Optical Coherence , Delayed DiagnosisABSTRACT
Primary central nervous system lymphoma is one of the most infrequent brain tumours, accounting for 3% of primary central nervous system neoplasms. In addition to its low prevalence, clinical presentation is usually nonspecific, leading to diagnostic delay. Intraocular involvement occurs in 15% of cases, and disease onset in this location is even rarer. We present a case of a patient with intermediate uveitis as the first clinical manifestation of this neoplasm.
ABSTRACT
BACKGROUND: Although solid information on the natural history of primary progressive multiple sclerosis (PPMS) is available, evidence regarding impact of disease activity on PPMS progression remains controversial. OBJECTIVE: To describe the clinical characteristics, presence or absence of MRI activity, and natural history of a PPMS cohort from two referral centers in Argentina and assess whether clinical and/or radiological disease activity correlated with disability worsening. METHODS: Retrospective study conducted at two MS clinics in Buenos Aires, Argentina, through comparative analysis of patients with and without evidence of disease activity. RESULTS: Clinical and/or radiologic activity was presented in 56 (31%) of 178 patients. When stratified by age at onset, we found that for every 10 years of increase in age at onset, risk of reaching EDSS scores of 4 and 6 increased by 26% and 31%, respectively (EDSS 4: HR 1.26, CI 95%: 1.06-1.50; EDSS 6: HR 1.31, CI 95%: 1.06-1.62). Patients who presented clinical exacerbations reached EDSS scores of 6, 7 and 8 faster than those without associated exacerbations (p = 0.009, p = 0.016 and p = 0.001, respectively). Likewise, patients who presented gadolinium-enhancing lesions during the course of disease reached EDSS scores of 7 earlier (p = 0.002). CONCLUSION: Older age at onset and presence of clinical and/or radiological disease activity correlated with accelerated disability progression in this cohort of PPMS patients.
ABSTRACT
TITLE: Neurolinfomatosis primaria de cola de caballo como manifestacion inicial del virus de la inmunodeficiencia humana.
Subject(s)
Cauda Equina/pathology , Lymphoma, AIDS-Related/diagnosis , Lymphoma, Large B-Cell, Diffuse/diagnostic imaging , Neurolymphomatosis/etiology , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoma, Renal Cell , Cauda Equina/diagnostic imaging , Cytarabine/administration & dosage , Gait Disorders, Neurologic/etiology , Humans , Kidney Neoplasms , Lymphoma, AIDS-Related/cerebrospinal fluid , Lymphoma, AIDS-Related/diagnostic imaging , Lymphoma, AIDS-Related/drug therapy , Lymphoma, Large B-Cell, Diffuse/cerebrospinal fluid , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Large B-Cell, Diffuse/etiology , Male , Methotrexate/administration & dosage , Middle Aged , Neoplasms, Second Primary/diagnosis , Neoplasms, Second Primary/diagnostic imaging , Neoplasms, Second Primary/drug therapy , Neoplasms, Second Primary/etiology , Neurolymphomatosis/cerebrospinal fluid , Neurolymphomatosis/diagnostic imaging , Neurolymphomatosis/drug therapy , Rituximab/administration & dosageABSTRACT
TITLE: Linfoma B intravascular hipotalamico en una paciente inmunocompetente.
Subject(s)
Hypothalamus/blood supply , Lymphoma, B-Cell/pathology , Vascular Neoplasms/pathology , Aged , Combined Modality Therapy , Confusion/etiology , Cranial Irradiation , Female , Glucocorticoids/therapeutic use , Humans , Hypothalamus/diagnostic imaging , Hypothalamus/pathology , Hypothyroidism/etiology , Immunocompetence , Lymphoma, B-Cell/complications , Lymphoma, B-Cell/diagnostic imaging , Lymphoma, B-Cell/therapy , Neoplasm Invasiveness , Positron Emission Tomography Computed Tomography , Sleep Disorders, Circadian Rhythm/etiology , Vascular Neoplasms/complications , Vascular Neoplasms/diagnostic imaging , Vascular Neoplasms/therapy , Vasopressins/deficiency , Weight LossABSTRACT
TITLE: Linfoma primario de adenohipofisis en una paciente inmunocompetente.
Subject(s)
Lymphoma, Large B-Cell, Diffuse , Pituitary Neoplasms , Aged , Fatal Outcome , Female , Humans , Immunocompetence , Lymphoma, Large B-Cell, Diffuse/diagnostic imaging , Lymphoma, Large B-Cell, Diffuse/therapy , Pituitary Neoplasms/diagnostic imaging , Pituitary Neoplasms/therapyABSTRACT
TITLE: Leucoencefalopatia posterior reversible de afectacion troncoencefalica y medular aislada.
