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1.
Eur J Nucl Med Mol Imaging ; 50(13): 3851-3861, 2023 11.
Article in English | MEDLINE | ID: mdl-37584725

ABSTRACT

INTRODUCTION: NeoB and RM2 are the most investigated gastrin-releasing peptide receptor (GRPR)-targeting radiotracers in preclinical and clinical studies. Therefore, an extensive side-by-side comparison of the two radiotracers is valuable to demonstrate whether one has advantages over the other. Accordingly, this study aims to compare the in vitro and in vivo characteristics of radiolabeled NeoB and RM2 to guide future clinical studies. METHOD: The stability of the radiolabeled GRPR analogs was determined in phosphate buffered saline (PBS), and commercially available mouse and human serum. Target affinity was determined by incubating human prostate cancer PC-3 cells with [177Lu]Lu-NeoB or [177Lu]Lu-RM2, + / - increasing concentrations of unlabeled NeoB, RM2, or Tyr4-bombesin (BBN). To determine uptake and specificity cells were incubated with [177Lu]Lu-NeoB or [177Lu]Lu-RM2 + / - Tyr4-BBN. Moreover, in vivo studies were performed to determine biodistribution and pharmacokinetics. Finally, radiotracer binding to various GRPR-expressing human cancer tissues was investigated. RESULTS: Both radiotracers demonstrated high stability in PBS and human serum, but stability in mouse serum decreased substantially over time. Moreover, both radiotracers demonstrated high GRPR affinity and specificity, but a higher uptake of [177Lu]Lu-NeoB was observed in in vitro studies. In vivo, no difference in tumor uptake was seen. The most prominent difference in uptake in physiological organs was observed in the GRPR-expressing pancreas; [177Lu]Lu-RM2 had less pancreatic uptake and a shorter pancreatic half-life than [177Lu]Lu-NeoB. Furthermore, [177Lu]Lu-RM2 presented with a lower tumor-to-kidney ratio, while the tumor-to-blood ratio was lower for [177Lu]Lu-NeoB. The autoradiography studies revealed higher binding of radiolabeled NeoB to all human tumor tissues. CONCLUSION: Based on these findings, we conclude that the in vivo tumor-targeting capability of radiolabeled NeoB and RM2 is similar. Additional studies are needed to determine whether the differences observed in physiological organ uptakes, i.e., the pancreas, kidneys, and blood, result in relevant differences in organ absorbed doses when the radiotracers are applied for therapeutic purposes.


Subject(s)
Prostatic Neoplasms , Receptors, Bombesin , Animals , Humans , Male , Mice , Biological Transport , Bombesin , Cell Line, Tumor , Prostatic Neoplasms/pathology , Receptors, Bombesin/metabolism , Tissue Distribution
2.
An Otorrinolaringol Ibero Am ; 30(4): 371-80, 2003.
Article in Spanish | MEDLINE | ID: mdl-12940132

ABSTRACT

The laryngeal cartilage radionecrosis is an infrequent treatment complication with radiotherapy of head and neck tumoral lesions and it can present since a few months to many years later its application. We present the different evolution of two patients with laryngeal carcinoma treated with radiotherapy who developed laryngeal radionecrosis. The differential diagnosis with the recidiva and the primitive tumoral lesion are very important, as well as the diagnosis difficulty and its treatment.


Subject(s)
Laryngeal Diseases/etiology , Radiation Injuries/etiology , Radiotherapy/adverse effects , Aged , Humans , Laryngeal Diseases/surgery , Male , Middle Aged , Necrosis , Radiation Injuries/surgery
3.
An Otorrinolaringol Ibero Am ; 30(4): 389-96, 2003.
Article in Spanish | MEDLINE | ID: mdl-12940134

ABSTRACT

The middle facial necrosis is a rare pathology that can be found related to multiple processes that can provoque it: traumatic, chemical, infections, inflammatory and tumorals. So for its diagnosis we require a wide differential diagnosis. We present a clinic case of a nose aspirated cocaine female patient who came to our department with a middle-facial necrosis not telling to us in the anamnesis the cocaine use. We were obliged to do multiple diagnostic tests searching other possible causes.


Subject(s)
Cocaine-Related Disorders/complications , Facial Muscles/physiopathology , Muscular Diseases/etiology , Osteonecrosis/etiology , Osteonecrosis/physiopathology , Palate, Hard/pathology , Adult , Female , Humans , Necrosis
6.
An Otorrinolaringol Ibero Am ; 29(2): 117-24, 2002.
Article in Spanish | MEDLINE | ID: mdl-12053506

ABSTRACT

Reporting the case of a patient, seen in our Hospital Consulting Department, enduring heavy pulsatile tinnitus, following a craniocerebral traumatism. ENT examination was negative, but having the feeling of a carotid-cavernous fistula, angiographies confirmed this pathology. Embolisation of the fistula as treatment stopped the patient's symptomatology. We take the advantage of this case in order to review the etiology, the pathology, diagnostic measure and treatment of this condition.


Subject(s)
Carotid-Cavernous Sinus Fistula/complications , Tinnitus/etiology , Adolescent , Carotid-Cavernous Sinus Fistula/diagnosis , Carotid-Cavernous Sinus Fistula/etiology , Craniocerebral Trauma/complications , Humans , Magnetic Resonance Imaging , Male , Tinnitus/diagnosis , Tinnitus/epidemiology , Tomography, X-Ray Computed
7.
An Otorrinolaringol Ibero Am ; 28(5): 531-7, 2001.
Article in Spanish | MEDLINE | ID: mdl-11729722

ABSTRACT

Verrucous carcinoma is an odd kind from squamous or epidermoid carcinoma, amounting between 1 and 3.5% percent of the whole number of laryngeal growths. Its predominant sitting is glottic and are characterized through the pathological anatomy and its good prognosis. We report one case treated in our Department which evolved during 14 years and we point out its good prognosis and other particularities regarding its etiology, pathologic anatomy and diagnosis.


Subject(s)
Carcinoma, Verrucous/diagnosis , Laryngeal Neoplasms/diagnosis , Humans , Male , Middle Aged , Time Factors
8.
An Otorrinolaringol Ibero Am ; 28(4): 381-8, 2001.
Article in Spanish | MEDLINE | ID: mdl-11692425

ABSTRACT

Sarcoidosis is a disease affecting the reticulo-histiocytary system and characterized by its several manifestations, always linked to the same lesion: the epithelioid granuloma without caseous necrosis. We make a review of this disease so scarce in our consulting rooms, and consider all patients diagnosed in our Hospital during one year-term, with their manifestations in ENT-area as well in other specialties and compare our inventory with other published series.


Subject(s)
Paranasal Sinus Diseases/pathology , Sarcoidosis/pathology , Adult , Aged , Biopsy , Female , Humans , Male , Middle Aged
9.
An Otorrinolaringol Ibero Am ; 28(1): 59-68, 2001.
Article in Spanish | MEDLINE | ID: mdl-11265520

ABSTRACT

The paper is a review of the jugulotympanic paragangliomata seen in our Hospital in a 2 years term. The AA. discuss every case and achieve a checking of several therapeutics procedures accepted for these growths.


Subject(s)
Ear Neoplasms/diagnosis , Ear, Middle , Glomus Jugulare Tumor/diagnosis , Neoplasms, Multiple Primary/diagnosis , Paraganglioma/diagnosis , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged
10.
An Otorrinolaringol Ibero Am ; 28(6): 581-8, 2001.
Article in Spanish | MEDLINE | ID: mdl-11859620

ABSTRACT

Deep neck infections develop as aftermath of spreading infections from an initial focus to the neighbourhood and soft tissues of the neck, through routes offering lesser resistance as fascial sheets. These cervical pictures are not numerous and generally after infective focus bad treated, linked with concomitant factors easing the rapid spread. The presence of complications as the involvement of great blood vessels, mediastin or jeopardizing the air-way may darken the prognosis, for which reason its precocious diagnosis and correct behaviour are very decisive. The paper deals with one case of neck infect, following an acute banal pharyngitis without predisposing circumstances. Follows a review of the published bibliography.


Subject(s)
Fasciitis, Necrotizing/etiology , Pharyngitis/complications , Acute Disease , Combined Modality Therapy , Humans , Male , Middle Aged , Pharyngitis/diagnostic imaging , Pharyngitis/therapy , Tomography, X-Ray Computed
11.
An Otorrinolaringol Ibero Am ; 28(6): 589-97, 2001.
Article in Spanish | MEDLINE | ID: mdl-11859621

ABSTRACT

Biopsy cannula is a diagnostic tool allowing anatomopathological examination of tissue samples, achieved through a percutaneous perforation. Unlike puncture-aspiration with fine needle method that only permits a cytologic study, this technique eases the removal of pieces big enough to provide the knowledge of the whole architecture of the lesion. At length in other specialities in our has been forgotten perhaps for the great efficiency of PAFN on neck masses or as complement of traditional surgery. We present one case in which the biopsy-cannula showed its diagnostic usefulness. We also discuss on the technique and made a bibliographic perusal about the published literature.


Subject(s)
Head and Neck Neoplasms/pathology , Biopsy, Needle , Catheterization , Humans , Male , Middle Aged
12.
An Otorrinolaringol Ibero Am ; 28(6): 599-605, 2001.
Article in Spanish | MEDLINE | ID: mdl-11859622

ABSTRACT

Reporting the case of a man, 70-year-old, suffering a chronic obstructive lung disease of moderate degree linked to important Reinke's oedema, who underwent a tracheotomy, being troubled the immediate postoperative period with subcutaneous emphysema and pneumomediastinitis, complications resolved favourably in a ten days term, and the patient could be decannulated.


Subject(s)
Mediastinal Emphysema/diagnostic imaging , Subcutaneous Emphysema/diagnostic imaging , Tracheostomy/methods , Aged , Humans , Male , Mediastinal Emphysema/surgery , Neck/diagnostic imaging , Neck/surgery , Radiography , Subcutaneous Emphysema/surgery
13.
An Otorrinolaringol Ibero Am ; 27(5): 421-6, 2000.
Article in Spanish | MEDLINE | ID: mdl-11116943

ABSTRACT

Diffuse idiopathic skeletal hyperostosis is a rare cause of dysphagia, preferentially affecting older men. This condition is also known as Forestier's malady, being characterized by a paravertebral ossification of 4 contiguous vertebrae at least. Seldom is the last etiology evoked for high dysphagia after other possible diagnosis exclusion. The diagnosis is confirmed by standard or contrast radiography. Introductory treatment is medical, being the surgery indicated for serious or resisting cases. One case is reported with dysphagia as primary sign of Forestier's malady, and review of possible diagnostic exams and treatments.


Subject(s)
Emphysema/etiology , Hyperostosis, Diffuse Idiopathic Skeletal/complications , Aged , Emphysema/diagnostic imaging , Humans , Hyperostosis, Diffuse Idiopathic Skeletal/diagnostic imaging , Neck , Radiography
14.
An Otorrinolaringol Ibero Am ; 27(5): 445-55, 2000.
Article in Spanish | MEDLINE | ID: mdl-11116946

ABSTRACT

After 20 years of existence of this Department we decided to carry out a review of the characteristics of our series and also of the results of treatment, according to the protocol elaborated and followed in agreement with the Tumour Committee if the Hospital. 631 medical histories of patients diagnosed and operated for cancer of larynx between 1974 and 1990 were reviewed. 83 of which (13.154%) disappeared during the 5 year follow-up period. Epidemiological, clinical, location, extension and treatment fdata were considered as well as the survival results and a single descriptive statistical analysis performed. The mean age of our study was 59.02 years, showing a clear relation to exposure to tobacco (91.44% were smokers and 63.39% of more than 20 cigarettes per day). The predominant location of the growth was supraglottic (64.05% of cases) followed by glottic in 33.76%. The most frequently used surgical technique was the total laryngectomy and total and extended to either the pharynx or tongue basis in 76.28%, followed by supraglottic laryngectomy in 13m5%. The stages were rather advanced with predominance of stage III /40.60%) and stage IV (21.17%). Global survive rate of our series accounted for 68.61% while the adjusted survival rate was 71.4%.


Subject(s)
Laryngeal Neoplasms/surgery , Adult , Aged , Aged, 80 and over , Female , Humans , Laryngeal Neoplasms/mortality , Laryngeal Neoplasms/pathology , Male , Middle Aged , Neck Dissection , Neoplasm Staging , Prospective Studies , Retrospective Studies
15.
An Otorrinolaringol Ibero Am ; 27(3): 231-7, 2000.
Article in Spanish | MEDLINE | ID: mdl-11075472

ABSTRACT

A case of temporal bone eosinophilic granuloma is reported. The patient had no symptoms other than aural discharge, conductive hearing loss and postauricular swelling. Otic features of Langerhans cell histiocytosis, diagnosis preferences and therapeutic choices are reviewed.


Subject(s)
Bone Diseases/etiology , Histiocytosis, Langerhans-Cell/complications , Temporal Bone , Adolescent , Biopsy , Bone Diseases/diagnosis , Bone Diseases/pathology , Bone Diseases/surgery , Histiocytosis, Langerhans-Cell/diagnosis , Histiocytosis, Langerhans-Cell/surgery , Humans , Magnetic Resonance Imaging , Male , Temporal Bone/surgery , Tomography, X-Ray Computed
16.
An Otorrinolaringol Ibero Am ; 27(3): 293-9, 2000.
Article in Spanish | MEDLINE | ID: mdl-11075478

ABSTRACT

Giant pleomorphic adenoma is the most common neoplasm of salivary glands, specially of parotitis. Less frequently derives from minor salivary glands and, in the case, its size is small. We report one case of pleomorphic adenoma of great mass seated in a palatine salivary gland and avail the opportunity to review these sort of tumors.


Subject(s)
Adenoma, Pleomorphic/pathology , Salivary Gland Neoplasms/pathology , Salivary Glands, Minor/pathology , Adenoma, Pleomorphic/surgery , Aged , Aged, 80 and over , Female , Humans , Palate, Hard , Salivary Gland Neoplasms/surgery , Salivary Glands, Minor/surgery
17.
O.R.L.-DIPS ; 27(1): 32-36, ene. 2000. tab, graf
Article in Es | IBECS | ID: ibc-5855

ABSTRACT

El Síndrome de Apnea Obstructiva del Sueño (SAOS) ha adquirido una importancia creciente en los últimos años.En este estudio tratamos de evaluar el grado de conocimiento de los médicos de atención primaria sobre esta enfermedad. Para ello, seleccionamos una muestra de 130 médicos generalistas de la ciudad de Zaragoza. Remitimos por correo un cuestionario que constaba de 10 preguntas referentes a aspectos fisiológicos del sueño y su patología incluido el SAOS. 118 cuestionarios (90,7 por ciento) nos fueron devueltos. El 88,1 por ciento de la muestra contestó correctamente entre 4 y 8 preguntas. No hubo diferencias significativas en la puntuación total al agruparla por sexo o año de licenciatura. Es el grupo de menor edad el que contesta más acertadamente (p<0,05) y todos en general, responden mejor a las cuestiones relacionadas con el SAOS.Por todo ello concluimos que el conocimiento de los médicos generalistas sobre patología del sueño es alta (AU)


Subject(s)
Adult , Female , Male , Middle Aged , Humans , Physicians/classification , Physicians , Internal Medicine/education , Internal Medicine/methods , Surveys and Questionnaires , Surveys and Questionnaires/classification , Sleep Apnea Syndromes/classification , Sleep Apnea Syndromes/epidemiology , Sleep Apnea Syndromes/pathology , Health Knowledge, Attitudes, Practice , Risk Factors , Attitude of Health Personnel , Education, Medical, Undergraduate/standards , Education, Medical, Graduate/standards , Health Education/legislation & jurisprudence , Health Education/organization & administration , Health Education/standards , Education, Medical, Continuing/trends , Education, Medical, Continuing , Education, Medical, Continuing/methods
18.
An Otorrinolaringol Ibero Am ; 26(2): 117-23, 1999.
Article in Spanish | MEDLINE | ID: mdl-10230084

ABSTRACT

Crouzon's syndrome is a chapter of the craneosynostosis, congenital diseases characterized for the precocious closure of cranial sutures. It represents an autosomal dominant heredity. Recently has been find out that the mutation lies in the short arm of chromosome 10, which causes the alteration of type 2 receptor of growth factor of fibroblasts (FRFG2). Clinically together with the cranial deformities appear frequently malformations in ENT-sphere, but only in 3 percent of all cases has been observed otic changes. We present the case of a young girl of 16, bearing a Crouzon's syndrome, coming to our office because of bilateral hypacusis. Clinical examination and complementary tests showed bilateral atresia of both auditive meatus lack of mastoid pneumatization, anomalous facial route and heavy bilateral transmissive hearing impairment, together with septum nasi deflection and hypoplasy of paranasal sinuses.


Subject(s)
Craniofacial Dysostosis/complications , Craniofacial Dysostosis/diagnosis , Hearing Loss, Sensorineural/etiology , Nasal Obstruction/etiology , Adolescent , Audiometry, Pure-Tone , Chromosome Aberrations/genetics , Chromosome Disorders , Chromosomes, Human, Pair 12/genetics , Craniofacial Dysostosis/genetics , Female , Hearing Loss, Sensorineural/diagnosis , Humans , Nasal Obstruction/diagnosis , Nasal Septum/abnormalities , Point Mutation/genetics , Tomography, X-Ray Computed
19.
An Otorrinolaringol Ibero Am ; 26(1): 75-81, 1999.
Article in Spanish | MEDLINE | ID: mdl-10091367

ABSTRACT

Inverted papilloma (PI) is a benign neoplasm of nose and paranasal sinuses. IP's pathophysiology is characterized by its capacity to be locally destructive, its ability to grow rapidly and its tendency to recur. IP's association with carcinoma is about 13 percent of cases. The surgical treatment of IP has evolved over the years, with a progression toward more radical en bloc extirpation. The paper reports an inverted papilloma case of nasal cavities, with destruction of frontal sinus roof and intracranial extension aside frontal lobe displacement.


Subject(s)
Papilloma, Inverted/diagnosis , Paranasal Sinus Neoplasms/diagnosis , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neoplasm Invasiveness , Papilloma, Inverted/surgery , Paranasal Sinus Neoplasms/surgery
20.
Acta Otorrinolaringol Esp ; 49(3): 206-10, 1998 Apr.
Article in Spanish | MEDLINE | ID: mdl-9644859

ABSTRACT

UNLABELLED: The causes of death were studied in a series of 171 patients who died in a 5-year follow-up period, out of a total of 631 patients who underwent different surgical techniques for cancer of the larynx. MATERIAL AND METHODS: The case histories of 631 patients who had undergone surgery between 1974 and 1990 were reviewed; 83 did not have a 5-year follow-up and were excluded from the study. A descriptive and inferential statistical study was made of the remaining cases to determine the relation between cause of death and tumoral extension, primary location, degree of tumoral differentiation, surgical technique and other data. RESULTS: Ninety-one patients died from local or regional recurrence, 50 from distant metastases, 20 from diseases other than the tumor, and 10 from postoperative complications. These findings were studied with regard to factors such as tumor extension, location, surgical technique, etc. CONCLUSIONS: The main cause of death in surgery for cancer of the larynx was recurrence, either local, on the tumor bed (62 patients) or regional (29 patients). The mortality rate was higher in older patients, patients with lymph-node involvement in the postoperative histological study, and patients with less differentiated histological forms.


Subject(s)
Carcinoma/mortality , Carcinoma/surgery , Laryngeal Neoplasms/mortality , Laryngeal Neoplasms/surgery , Adult , Aged , Follow-Up Studies , Humans , Male , Middle Aged , Neoplasm Recurrence, Local , Neoplasm Staging , Prognosis , Retrospective Studies , Spain/epidemiology , Survival Rate
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