1.
Nucleosides Nucleotides Nucleic Acids
; 26(10-12): 1641-3, 2007.
Article
in English
| MEDLINE
| ID: mdl-18066843
ABSTRACT
Quadruplex-forming oligonucleotides containing INA [(R)-1-O-(1-pyrenylmethyl)glycerol] insertions have been designed and studied for their capacity to inhibit the expression of the KRAS oncogene in pancreatic adenocarcinoma cells. It is found that INA can influence the folding topology of the G-quadruplex. The oligonucleotides forming the most stable G-quadruplex (ODN-637) is found to exhibit the highest bioactivity.