Adherence to healthy dietary patterns and its association with physical fitness in military personnel.

INTRODUCTION: Poor nutritional status might impact in unintentional weight loss and decreased muscle mass and strength. The levels of physical fitness (PF) is a predictor of chronic diseases in future years. Also, evaluation of fitness is an essential factor for duty in occupations which are sensitive to time and emergency reaction. Since there is no literature that study the association between dietary patterns and the PF level in physically strenuous occupations, the aim of this study was to examine the relationship between dietary patterns and the PF level in military staffs. METHODS: This cross-sectional study was carried out in military zones of Iran. Typical dietary intakes were assessed by using a semi-quantitative food-frequency questionnaire. Mediterranean diet (MD) score and healthy diet indicator (HDI) score were calculated. PF tests were designed to test the muscular strength, endurance and cardiovascular respiratory fitness (CRF). RESULTS: Mean age of participants was 33.03±4.65 in the study. Referring to the performance in the PF tests, there was a correlation between tertiles of MD (OR 4.37, p=0.048) and HDI (OR 5.21, p=0.019) scores and suitable PF level in the crude and confounder adjusted models. Also, a negative relationship was found between body mass index and waist circumference with fitness score. CONCLUSIONS: We concluded that accompanying a medium or high adherence to a healthy dietary pattern will have an impact on good level of PF and will result in a better working power and long-term health consequences among physically strenuous occupations.

Immunoregulation of Inflammatory and Inhibitory Cytokines by Vitamin D3 in Patients with Inflammatory Bowel Diseases.

Inflammatory bowel disease (IBD) is a group of idiopathic, chronic and relapsing inflammatory conditions of the gastrointestinal tract, caused by an aberrant and exaggerated immunological response in the gut. Supplementation of vitamin D3 in patients with IBD exerts both direct and indirect regulatory roles on the naïve T cells, thereby maintaining a balance between inflammatory and inhibitory cytokines. The direct actions of vitamin D3 on naïve T cells result in the proliferation of more regulatory T cells and inhibitory cytokines such as IL-4, IL-10 and IL-5. The binding of vitamin D to dendritic cells (DCs) through vitamin D receptors inhibits the action of IL-12 on DCs, resulting in the downregulation of Th1 and Th17. On the other hand, this interaction favours Th2 and Treg upregulation and facilitates the maintenance of immune homoeostasis between inflammatory and inhibitory cytokines which is essentially significant in the management of patients with IBD. The aim of this review was to explore the current and mounting scientific evidence on the roles of vitamin D3 in immunoregulation of inflammatory and inhibitory cytokines in patients with IBDs. An extensive literature search was conducted using keywords such as Vitamin D3*, IBD*, inflammatory cytokines*, inhibitory cytokines*, naïve-T-cells* and antigen presenting cells* through PubMed, SCOPUS and MEDLINE search engines. The results of the accumulated bodies of research that have been conducted demonstrate that vitamin D3 plays a major role not only in the immunoregulation of cytokines involved in the pathogenesis of IBDs but also in many other inflammatory disorders.