ABSTRACT
Scientific data recording and reporting systems are of a great interest for endorsing reproducibility and transparency practices among the scientific community. Current research generates large datasets that can no longer be documented using paper lab notebooks (PLNs). In this regard, electronic laboratory notebooks (ELNs) could be a promising solution to replace PLNs and promote scientific reproducibility and transparency. We previously analyzed five ELNs and performed two survey-based studies to implement an ELN in a biomedical research institute. Among the ELNs tested, we found that Microsoft OneNote presents numerous features related to ELN best functionalities. In addition, both surveyed groups preferred OneNote over a scientifically designed ELN (PerkinElmer Elements). However, OneNote remains a general note-taking application and has not been designed for scientific purposes. We therefore provide a quick guide to adapt OneNote to an ELN workflow that can also be adjusted to other nonscientific ELNs.
Subject(s)
Information Storage and Retrieval/methods , Research Design/trends , Biomedical Research , Laboratories , Reproducibility of Results , Software , WorkflowABSTRACT
Resumen: El estado epiléptico no convulsivo como diagnóstico diferencial de delirio es una enfermedad clínica cada más prevalente en la población geriátrica. Su manifestación se ha relacionado con múltiples factores de riesgo; la confusión es la manifestación clínica inicial en 49% de los pacientes, que interfiere en su calidad de vida y funcionalidad. El diagnóstico diferencial con el delirio es esencial debido a ser clínicamente similar, por lo que descartar factores predisponentes y precipitantes y corregir causas reversibles forma parte del manejo inicial. El electroencefalograma con correlación clínica establece el diagnóstico de acuerdo con el tipo de manifestación de estado epiléptico no convulsivo. El diagnóstico correcto permite su identificación y confirmación tempranas para otorgar el tratamiento anticonvulsivo ideal basado en la edad del paciente, comorbilidades y trastornos psiquiátricos acompañantes que permiten al paciente geriátrico disminuir su morbilidad y mortalidad y preservar su funcionalidad.
Abstract: The non-convulsive epileptic status (NCES) as a differential diagnosis of delirium is an increasingly prevalent clinical entity in the geriatric population. Its presentation has been linked to many risk factors and confusion is the initial clinical manifestation in up to 49% of the patients which interferes with their quality of life and conditions disability. Differential diagnosis with delirium is essential because its similarity, so discard predisposing and precipitating factors and correct reversible causes is part of the initial management. The electroencefalogram (EEG) with clinical correlation establishes the diagnosis according to the type of non-convulsive epileptic status presentation. Diagnostic suspicion allows the identification and early confirmation, for choosing the ideal anticonvulsant treatment based on the patient's age, comorbidities and psychiatric disorders in the geriatric patients, to reduce morbidity and mortality and preserve their functionality.
