ABSTRACT
BACKGROUND: Atopic dermatitis (AD) is a highly prevalent, chronic relapsing condition in childhood with significant financial burden and impact on the quality of life of patients and caregivers. Proactive maintenance treatment with moisturizing agents is the mainstay AD therapy. OBJECTIVES: The aim of this study was to assess the cost-effectiveness of a non-steroidal barrier cream (Atopiclair), compared to regular emollient in pediatric patients with mild-to-moderate AD. METHODS: A Markov decision model was developed to evaluate the cost-effectiveness of Atopiclair versus regular emollient in 12 Asia-Pacific countries, grouped by income categories based on gross domestic product (GDP) per capita. Data was obtained from structured literature review, expert opinion, fee schedules, and findings from a 2012 survey of 12 Asia-Pacific countries. Analysis was performed a societal perspective. RESULTS: In the base case analysis, Atopiclair was cost-effective against regular emollient, with USD786, USD499, and USD289 in cost savings per year for high, middle, and low-income countries, respectively. Sensitivity analyses showed that Atopiclair remained cost-effective versus regular emollient. CONCLUSIONS: Modelling analysis showed that Atopiclair is a cost-effective treatment compared to regular emollient for mild-to-moderate pediatric AD in the countries included in the study.
Subject(s)
Dermatitis, Atopic/drug therapy , Dermatologic Agents/therapeutic use , Dietary Fats/therapeutic use , Emollients/therapeutic use , Glycyrrhetinic Acid/therapeutic use , Plant Extracts/therapeutic use , Asia , Child , Cost-Benefit Analysis , Dermatitis, Atopic/economics , Dermatologic Agents/economics , Dietary Fats/economics , Emollients/economics , Glycyrrhetinic Acid/economics , Humans , Markov Chains , Plant Extracts/economics , Quality of Life , Treatment OutcomeABSTRACT
Secondary Moyamoya disease, also known as Moyamoya syndrome has been rarely associated with Down syndrome. In pediatric patients, the usual presentation is that of ischemic stroke. Here is reported a 4-year-old child with Down syndrome and Moyamoya syndrome who presented with acute-onset right hemiplegia. A high index of suspicion is necessary to make the diagnosis.
Subject(s)
Down Syndrome/complications , Moyamoya Disease/complications , Stroke/etiology , Child, Preschool , Down Syndrome/diagnosis , Humans , Magnetic Resonance Angiography , Male , Moyamoya Disease/diagnosis , Stroke/diagnosisABSTRACT
Rendu Osler Weber syndrome is a rare vascular disorder and presents with diagnostic problems because of varied and sometimes misleading clinical presentations and radiological findings. A case report of Rendu Osler Weber syndrome in which the diagnosis was suggested in view of presence of pulmonary Arterio-Venous malformations is described. The article also indicates the role of special imaging modalities like contrast echocardiography and pulmonary angiography in approaching the case.
Subject(s)
Arteriovenous Malformations/complications , Pulmonary Artery/abnormalities , Pulmonary Veins/abnormalities , Telangiectasia, Hereditary Hemorrhagic/complications , Arteriovenous Malformations/diagnosis , Child, Preschool , Humans , Male , Telangiectasia, Hereditary Hemorrhagic/diagnosisABSTRACT
Soto's syndrome, also known, as cerebral gigantism is a rare syndrome characterized by large size, large head and early psychomotor delay. Major diagnostic criteria include facial dysmorphisms, advanced bone age and developmental delay. Herein, a case of Soto's syndrome with rare finding of bilateral hydronephrosis and hydroureters is being reported.
