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Free Radic Res ; 34(6): 629-37, 2001 Jun.
Article in English | MEDLINE | ID: mdl-11697038

ABSTRACT

4-Hydroxynonenal (HNE) is one of the major end products of lipid peroxidation. Here we show that the exposure of murine erythroleukemia (MEL) cells to 1 microM HNE, for 10.5 h over 2 days, induces a differentiation comparable with that observed in cells exposed to DMSO for the whole experiment (7 days). The exposure of MEL cells for the same length of time demonstrates a higher degree of differentiation in HNE-treated than in DMSO-treated MEL cells. The protooncogene c-myc is down-modulated early, in HNE-induced MEL cells as well as in DMSO-treated cells. However, ornithine decarboxylase gene expression first increases and then decreases, during the lowering of the proliferation rate. These findings indicate that HNE, at a concentration physiologically found in many normal tissues and in the plasma, induces MEL cell differentiation by modulation of specific gene expression.


Subject(s)
Aldehydes/pharmacology , Cell Differentiation/drug effects , Growth Inhibitors/pharmacology , Animals , Cell Division/drug effects , Gene Expression/drug effects , Genes, myc , Leukemia, Erythroblastic, Acute , Mice , Ornithine Decarboxylase/genetics , Tumor Cells, Cultured
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