Russell body esophagitis and Barrett's esophagus.

85-year-old woman being studied for anemia, an endoscopy is performed where there is evidence of two areas with metaplastic appearance in the distal portion of the esophagus, which are biopsied. Histologic exam reveals a lymphoplasmacytic infiltrate with the presence of Russell cells and foci of intestinal metaplasia without evidence of dysplasia. Although not the usual location, it must be acknowledged that there is a possibility of recognizing Russell bodies in the context of esophageal inflammation and its possible association with Barrett's esophagus.

Melanoma metastasis in the stomach: correlation of endoscopic findings with microscopic images.

An 85-year-old female patient with a history of melanoma 2 years ago, with anemia and signs of upper gastrointestinal bleeding. She underwent gastroscopy in which 4 ulcerated and pigmented lesions located in the body and subcardial region were recognized. The anatomopathological study confirmed the diagnosis of metastatic melanoma.

[Leiomyosarcoma of the nasal fossa. A case report]. / Leiomiosarcoma de fosa nasal. A propósito de un caso.

A 54-year-old female patient presented with a left nasal obstruction. On physical examination a pink delimited mass in the left nostril was observed. A cranial computed tomography scan revealed an expansive mass in the upper anterior third of the left nasal fossa, partially obstructing it. Endoscopic resection of the mass was performed. Histopathology revealed an atypical mesenchymal proliferation formed by cells disposed in disorganized and interconnected long bundles. Tumor cells had abundant eosinophilic cytoplasm and an oval, vesicular and hyperchromatic nucleus. Frequent mitotic figures were observed, many of them atypical. Necrosis was not observed. Immunohistochemistry showed tumor cells to be positive for calponin, muscle specific actin, caldesmon and smooth muscle specific myosin. Ki-67 index proliferation was 30%. A diagnosis of leiomyosarcoma of the nasal fossa was established.

Leiomiosarcoma de fosa nasal. A propósito de un caso / Leiomyosarcoma of the nasal fossa. A case report

Paciente mujer de 54 años que acude a consulta por un cuadro de obstrucción nasal. En la exploración física se observa una lesión rosada, bien delimitada, en la fosa nasal izquierda. Se realiza TAC de macizo facial en la que se observa una masa expansiva a nivel del tercio anterosuperior de la fosa nasal izquierda. Se realiza resección endoscópica. Histológicamente se observa una proliferación mesenquimal atípica constituida por células que forman haces largos desorganizados y entrecruzados. Las células tumorales presentan un citoplasma amplio eosinófilo y núcleo ovalado, vesiculoso e hipercromático. Se aprecian frecuentes figuras mitóticas, muchas de ellas atípicas. No se observa necrosis. En el estudio inmunohistoquímico se evidenció inmunorreactividad de las células tumorales frente a calponina, actina muscular específica, caldesmón y miosina específica de músculo liso. El índice de proliferación frente a KI-67 fue de un 30%. Con todos estos hallazgos se estableció el diagnóstico de leiomiosarcoma de fosa nasal.(AU)

A 54-year-old female patient presented with a left nasal obstruction. On physical examination a pink delimited mass in the left nostril was observed. A cranial computed tomography scan revealed an expansive mass in the upper anterior third of the left nasal fossa, partially obstructing it. Endoscopic resection of the mass was performed. Histopathology revealed an atypical mesenchymal proliferation formed by cells disposed in disorganized and interconnected long bundles. Tumor cells had abundant eosinophilic cytoplasm and an oval, vesicular and hyperchromatic nucleus. Frequent mitotic figures were observed, many of them atypical. Necrosis was not observed. Immunohistochemistry showed tumor cells to be positive for calponin, muscle specific actin, caldesmon and smooth muscle specific myosin. Ki-67 index proliferation was 30%. A diagnosis of leiomyosarcoma of the nasal fossa was established.(AU)

Carcinosarcoma of the gallbladder diagnosed in a cholecystectomy specimen.

We report the case of a patient with an incidental diagnosis of gallbladder adenocarcinoma with chondrosarcomatoid areas in a cholecystectomy specimen. Since it is associated with a worse prognosis when compared to usual carcinoma, we need to understand this entity to offer our patients a better treatment.

Bone metaplasia in ovarian metastasis of colorectal carcinoma.

Calcerrada Alises E, et al. presented the case of a hyperplastic polyp with bone metaplasia. We present the case of a patient with metastatic colorectal adenocarcinoma in the ovary, with bone metaplasia in the ovarian metastasis but not in the primary lesion.

Primary Ewing's sarcoma of the small intestine.

17 year old female teenager with abdominal pain secondary to pelvic mass of 12 x 10 cm, which seems to depend on ovary. Surgery is scheduled for removal of the tumor, during which it is observed that the lesion originates in the ileum. The histopathological study shows a neoplasm of small round cells with nucleoli and scant cytoplasm. The tumor cells are immunoreactive to CD99 and ERG, being negative for cytokeratins, FLI1, WT1, DOG1 and lymphoid markers. By means of FISH, a rearrangement of the EWSR1 gene was demonstrated. By integrating these molecular and immunohistochemical findings with the morphology, it was diagnosed as Ewing's sarcoma. This aggressive and infrequent tumor originates from neuroectodermal cells and usually develops in the long bones of pediatric and young adult patients, although exceptionally it can occur in other locations. At the intestinal level, it mainly affects the ileum, with a non-specific pain and fatigue clinic. The treatment of choice is surgery for resection of the affected loop, followed by chemotherapy.

Recalcitrant granulomatous periorificial dermatitis with good response to low-dose oral isotretinoin.

Granulomatous periorificial dermatitis is a clinical variant of periorificial dermatitis. We present the case of an 18-year-old girl with several reddish papular lesions in the perioral, perinasal, and periorbital regions unresponsive to conventional therapy. After 6 months of therapy with low-dose oral isotretinoin, the lesions fully remitted.