ABSTRACT
The methanol extract of the leaves of E. adenophorum (100, 200 and 300 mg/kg, po) showed significant analgesic activity, as compared to standard drugs diclofenac sodium and pentazocine, employing acetic acid-induced writhing test, tail immersion test and tail flick test models.
Subject(s)
Ageratina , Analgesics/pharmacology , Ageratina/chemistry , Analgesics/isolation & purification , Animals , Diclofenac/pharmacology , Female , Male , Methanol , Mice , Pain Measurement , Pentazocine/pharmacology , Plant Extracts/pharmacology , Plant Leaves/chemistryABSTRACT
The methanol extract of Clitoria ternatea L. root (MECTR) blue flowered variety (Family: Fabaceae), was evaluated for its anti-pyretic potential on normal body temperature and yeast-induced pyrexia in albino rats. Yeast suspension (10 ml/kg body wt.) increased rectal temperature after 19 hours of subcutaneous injection. The extract, at doses of 200, 300 and 400 mg/kg body wt., p.o., produced significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose-dependent manner. The effect extended up to 5 hours after the drug administration. The anti-pyretic effect of the extract was comparable to that of paracetamol (150 mg/kg body wt., p.o.), a standard anti-pyretic agent.
Subject(s)
Analgesics, Non-Narcotic/pharmacology , Body Temperature/drug effects , Clitoria , Fever/prevention & control , Phytotherapy , Plant Extracts/pharmacology , Administration, Oral , Analgesics, Non-Narcotic/administration & dosage , Analgesics, Non-Narcotic/therapeutic use , Animals , Dose-Response Relationship, Drug , Female , Male , Plant Extracts/administration & dosage , Plant Extracts/therapeutic use , Plant Roots , Rats , Rats, Wistar , YeastsABSTRACT
The anti-inflammatory activity of Ionidium suffruticosam (Violaceae) methanol extract was evaluated on carrageenin, histamine and serotonin-induced rat hind paw oedema acute models. The extract at doses of 200 and 400 mg/kg has been found to possess significant anti-inflammatory activity on the tested experimental models. The extract at the dose level of 400 mg/kg exhibited maximum anti-inflammatory activity in all the animal models. In a chronic test, the extract (400 mg/kg) showed 42.78% reduction in granuloma weight. The effect produced by the extract was comparable to that of phenylbutazone, a proto type of a non-steroidal anti-inflammatory agent.
Subject(s)
Anti-Inflammatory Agents/pharmacology , Edema/prevention & control , Phytotherapy , Plant Extracts/pharmacology , Violaceae , Administration, Oral , Animals , Anti-Inflammatory Agents/administration & dosage , Anti-Inflammatory Agents/therapeutic use , Carrageenan , Cotton Fiber , Dose-Response Relationship, Drug , Edema/chemically induced , Granuloma, Foreign-Body/prevention & control , Histamine , Male , Plant Extracts/administration & dosage , Plant Extracts/therapeutic use , Plant Structures , Rats , Rats, Wistar , SerotoninABSTRACT
The analgesic activity of methanol extract of Cleome viscosa, given orally at the doses of 100, 200, 400 mg/kg was evaluated for its analgesic activity in mice using the acetic acid-induced writhing and the tail flick, tail clip, tail immersion methods. The extract showed promising activity in all the tests.
