ABSTRACT
Vitamin D plays an important role in the metabolism of calcium and phosphorus and bone health, but is also involved in several other important biological processes. Epidemiological studies indicate that the prevalence of vitamin D deficiency is very high globally. Recent studies have shown an association between vitamin D status with the prevalence and outcomes of several cancers that includes gastric cancer, which is a common cancer with a poor prognosis. The early diagnosis and treatment of gastric cancer, in its advanced stages, is difficult and patients who are diagnosed at an advanced stage have a poor prognosis. In this review, we have summarized the recent studies investigating the association between vitamin D status and the incidence and mortality of gastric cancer.
Subject(s)
Stomach Neoplasms/etiology , Vitamin D Deficiency/complications , Vitamin D/adverse effects , Vitamin D/blood , Humans , Incidence , Prevalence , Risk Factors , Stomach Neoplasms/blood , Stomach Neoplasms/epidemiology , Ultraviolet Rays , United States/epidemiology , Vitamins/adverse effects , Vitamins/bloodABSTRACT
Hematological parameters have emerged as independent determinants of high serum concentrations of uric acid (UA) and predictive factors in the evaluation of the total cardiovascular risk in patients with essential hypertensive. Here, we have investigated the possible relationships between hematological factors and serum uric acid levels in hypertensive patients recruited as part of Mashhad Stroke and Heart Atherosclerotic Disorders cohort study. Two-thousand three-hundred and thirty-four hypertensive individuals were recruited from this cohort and these were divided into two groups; those with either high or low serum UA concentrations. Demographic, biochemical, and hematological characteristics of population were evaluated in all the subjects. Logistic-regression analysis was performed to determine the association of hematological parameters with hypertension (HTN). Of the 2334 hypertensive subjects, 290 cases had low UA, and 2044 had high serum UA concentrations. Compared with the low UA group, the patients with high serum UA, had higher values for several hematological parameters, whilst platelet counts (PLT) were lower. Multiple linear regression analysis showed that PLT and serum high sensitivity-c reactive protein (hs-CRP) were correlated with serum UA level. Stepwise multiple logistic regression model confirmed that platelet distribution width (PDW) and gender were independent determinant of a high serum UA. PDW and PLT appear to be independently associated with serum UA level in patients with HTN. © 2018 BioFactors, 44(6):532-538, 2018.
Subject(s)
Blood Platelets/pathology , Blood Pressure , Essential Hypertension/blood , Uric Acid/blood , Adult , Anthropometry , Biomarkers/blood , C-Reactive Protein/metabolism , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Cohort Studies , Erythrocyte Indices , Essential Hypertension/diagnosis , Female , Humans , Logistic Models , Male , Mean Platelet Volume , Middle Aged , Platelet Count , Risk Factors , Sex Factors , Triglycerides/bloodABSTRACT
Gastric cancer (GC) has a high mortality rate with a poor 5-year survival. Helicobacter pylori (H. pylori) is present as part of the normal flora of stomach. It is found in the gastric mucosa of more than half of the world population. This bacterium is involved in developing H. pylori-induced GC due to the regulation of different micro ribonucleic acid (miRNA or miR). miRNAs are small noncoding RNAs and are recognized as prognostic biomarkers for GC that may control gene expression. miRNAs may function as tumor suppressors, or oncogenes. In this review, we evaluated studies that investigated the ectopic expression of miRNAs in the prognosis of H. pylori positive and negative GC.
Subject(s)
Helicobacter pylori/isolation & purification , MicroRNAs/analysis , Stomach Neoplasms/diagnosis , Stomach Neoplasms/microbiology , Helicobacter pylori/pathogenicity , Humans , Predictive Value of Tests , Stomach Neoplasms/geneticsABSTRACT
BACKGROUND: The aim of study was to compare the serum level of magnesium in mothers having low birth weight with those having normal birth weight neonates. METHODS: In a case-control study, women who delivered low birth weight neonate (cases), compared with normal birth weight (controls) in serum concentration of magnesium. Blood samples collected within 24 h after delivery. Concentration of magnesium assessed by standard atomic absorption spectro-photometry. Multiple linear regression analysis was performed to control of potential confounding variables. RESULTS: A total of 116 mothers (67 cases and 49 control) were studied. Mothers in two groups did not differ in age, body mass index, and socioeconomic or demographic factors. Maternal magnesium concentration did not differ between two groups 0.86 ± 0.11 m.mol/l versus 0.94 ± 0.22 m.mol/l respectively (P = 0.09). CONCLUSION: There is no significant difference between serum magnesium levels of low birth weight infants' mother and normal weight infants' mother.
