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Exp Cell Res ; 339(2): 252-60, 2015 Dec 10.
Article in English | MEDLINE | ID: mdl-26407906

ABSTRACT

miRNA-125 family, which is a highly conserved miRNA family throughout evolution, is consist of miRNA-125a-3p, miRNA-125a-5p, miRNA-125b-1 and miRNA-125b-2.The aberrant expression of miR-125 familyis tightly related to tumorigenesis and tumor development. The downstream targets of miRNA-125 include transcription factors like STAT3, cytokines like IL-6 and TGF-ß, tumor suppressing protein p53, pro-apoptotic protein Bak1 and RNA binding protein HuR et al. Through regulating these downstream targets miR-125 family is involved in regulating tumorigenesis and tumor development. Nowadays, miR-125b have already became a putative and valuable biomarker for cancer diagnosis, treatment and prognosis. In this review, we mainly summarize the dual function of miRNA-125 family in suppression and promotion of cancer cells and further elaborate its regulatory mechanisms from four facets, proliferation, apoptosis, invasion or metastasis and immune response.


Subject(s)
MicroRNAs/metabolism , Neoplasms/genetics , Neoplasms/pathology , Animals , Apoptosis , Cell Proliferation , Humans , MicroRNAs/classification , MicroRNAs/genetics
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