ABSTRACT
Complex regional pain syndrome (CRPS) and fibromyalgia (FM) share many features. Both can cause severe pain and are considered to have a mechanism of action, including dysfunction of the sympathetic nervous system. However, they have clinical differences in pain range and degree. The present study aimed to find neurophysiologic differences between CRPS and FM using quantitative electroencephalography (QEEG). Thirty-eight patients with CRPS and 33 patients with FM were included in the analysis. Resting-state QEEG data were grouped into frontal, central, and posterior regions to analyze for regional differences. General linear models were utilized to test for group differences in absolute and relative powers. As a result, the CRPS group relative to FM group showed lower total absolute powers in the beta band (Fâ=â5.159, Pâ<â.05), high beta (Fâ=â14.120, Pâ<â.05), and gamma band (Fâ=â15.034, Pâ<â.05). There were no significant differences between 2 groups in the delta, theta, and alpha bands. The present findings show that the CRPS and FM groups differ mainly in the high frequency, which may reflect their distinct pathophysiology and symptomatology. Our study suggests that the QEEG differences can be clinically useful in assessing brain function in patients with CRPS and FM.
Subject(s)
Beta Rhythm , Complex Regional Pain Syndromes/diagnostic imaging , Electroencephalography/statistics & numerical data , Fibromyalgia/diagnostic imaging , Gamma Rhythm , Adult , Brain/diagnostic imaging , Brain/physiopathology , Complex Regional Pain Syndromes/physiopathology , Electroencephalography/methods , Female , Fibromyalgia/physiopathology , Humans , Linear Models , Male , Middle AgedABSTRACT
The glycemic index (GI) and glycemic load (GL) have been considered risk factors for breast cancer, but association studies of breast cancer risk using simple GI and GL might be affected by confounding effects of the overall diet. A total of 357 cases and 357 age-matched controls were enrolled, and dietary intake was assessed using a validated food frequency questionnaire (FFQ) with 103 food items. GI and GL dietary patterns were derived by reduced rank regression (RRR) method. The GI and GL pattern scores were positively associated with breast cancer risk among postmenopausal women [OR (95%CI): 3.31 (1.06-10.39), p for trend=0.031; 9.24 (2.93-29.14), p for trend<0.001, respectively], while the GI pattern showed no statistically significant effects on breast cancer risk, and the GL pattern was only marginally significant, among premenopausal women (p for trend=0.043). The GI and GL pattern scores were positively associated with the risk of breast cancer in subgroups defined by hormone receptor status in postmenopausal women. The GI and GL patterns based on all food items consumed were positively associated with breast cancer.
Subject(s)
Breast Neoplasms/epidemiology , Diet/statistics & numerical data , Dietary Carbohydrates , Glycemic Index , Postmenopause , Premenopause , Adult , Case-Control Studies , Eating , Female , Humans , Middle Aged , Odds Ratio , Regression AnalysisABSTRACT
The effects of soy products and isoflavone on breast cancer recurrence were compared according to receptor status including epidermal growth factor receptor-2 (HER2) with 339 Korean women. Dietary intake of soy foods was assessed using a validated food frequency questionnaire with 103 food items. Twenty-five patients experienced breast cancer recurrence, 17 patients were HER2 negative, and 8 patients were HER2 positive. Legume intake (mostly from black soybeans) was inversely associated with the risk of breast cancer recurrence in HER2 negative cancer patients (HR: 0.27, 95% CI: 0.13-0.57, P for trend < 0.01), whereas legume intake was positively associated in HER2 positive cancer patients (P for trend = 0.02). In HER2 negative cancer patients, isoflavone was inversely associated with breast cancer recurrence (HR: 0.23, 95% CI: 0.06-0.89; P for trend = 0.01). Total soy intake was not associated with an increased risk of cancer recurrence. In conclusion, overall soy food intake might not affect the risk of cancer recurrence, but high intake of soy isoflavones increased the risk of cancer recurrence in HER2-positive breast cancer patients. However, further research is needed to confirm these results due to the small number of cancer recurrence events.
Subject(s)
Breast Neoplasms/epidemiology , Diet , Isoflavones/administration & dosage , Neoplasm Recurrence, Local/epidemiology , Receptor, ErbB-2/analysis , Soy Foods , Adult , Aged , Breast Neoplasms/chemistry , Breast Neoplasms/prevention & control , Female , Humans , Korea , Middle Aged , Neoplasm Recurrence, Local/chemistry , Neoplasm Recurrence, Local/prevention & control , Postmenopause , Premenopause , Receptors, Estrogen/analysis , Receptors, Progesterone/analysis , Risk Factors , Glycine max/chemistryABSTRACT
We evaluated the association between dietary patterns and breast cancer risk according to menopausal and hormone receptor status among Korean women. In a study with 357 cases and 357 age-matched controls, dietary patterns (vegetable-seafood and meat-starch) were derived via principle component analysis based on 39 food groups from a food frequency questionnaire. The relation between dietary patterns and breast cancer risk was assessed by using multivariate logistic regression. The vegetable-seafood pattern was inversely associated with breast cancer risk [odds ratio (OR) and 95% confidence interval (CI) for high vs. low intake = 0.14 (0.08-0.25); P for trend < 0.001]. No association between the meat-starch pattern and breast cancer risk was found. The association between dietary patterns and breast cancer risk was not modified by menopausal and combined hormone receptor status. These findings indicate that a diet rich in vegetables and seafood is associated with a decreased breast cancer risk in Korean women.
