1.
Chem Commun (Camb)
; 60(55): 7025-7028, 2024 Jul 04.
Article
in English
| MEDLINE
| ID: mdl-38888299
ABSTRACT
We describe a versatile and tuneable thiol responsive linker system using thiovinylketones, which relies on the conjugate addition-elimination mechanism of Michael acceptors for the traceless release of therapeutics. In a proof-of-principle study, we translate our findings to exhibit potent thiol-cleavable antibiotic prodrugs and antibody-drug conjugates.