ABSTRACT
A readily available copper(I) catalyst, in an ionic liquid, can effect three-component coupling of aldehydes, amines and alkynes to generate propargylamines in high yields.
Subject(s)
Copper/chemistry , Ionic Liquids/chemistry , Pargyline/analogs & derivatives , Propylamines/chemical synthesis , Aldehydes/chemistry , Alkynes/chemistry , Amines/chemistry , Catalysis , Molecular Structure , Pargyline/chemical synthesis , Pargyline/chemistry , Propylamines/chemistry , StereoisomerismABSTRACT
[reaction: see text] New Pd(II) complexes with bisimidazole ligands were prepared and proved to be effective catalysts for the Heck reaction under phosphine-free conditions using ionic liquids as solvents. This system could be recycled five times without any loss of catalytic activity.
ABSTRACT
[reaction: see text] In connection with the known diyne-ene [2 + 2 + 2] cycloaddition reactions mediated by titanium aryloxides, the ability of titanium alkoxides to promote coupling of a titanacyclopentadiene with an alkene has been assessed for the isomerization-free preparation of 1,3-cyclohexadienes. The successful cycloaddition by titanium alkoxides is predicated on the use of homoallylic alcohols as the olefin component. With secondary homoallylic alcohols, high 1,3-diastereoselectivity is observed, which lends itself to enantioselective preparation of functionalized 1,3-cyclohexadienes.
