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1.
Paediatr Perinat Epidemiol ; 24(5): 470-8, 2010 Sep.
Article in English | MEDLINE | ID: mdl-20670227

ABSTRACT

Malignant bone tumours in the paediatric age group (0-14 years) are uncommon; various aetiological theories exist and few reports of incidence, age and sex distributions have been published. We examined the incidence of childhood malignant bone tumours in one large single region of the UK over an extended period of 50 years. The West Midlands specialist regional children's tumour registry holds data on all malignancies and benign brain tumours in children under 15 years in the West Midlands region, which has a population of around 1 million children. Demographic and clinical data have been abstracted and diagnoses reviewed by a panel of expert pathologists. During the period 1957-2006, 259 cases of malignant paediatric bone tumours were diagnosed. There were 153 osteosarcomas, 78 Ewing sarcomas and 28 other primary bone tumours. The overall age standardised rate was 4.66, with no increase over time, although there was a significant increase in the incidence of Ewing sarcomas in the period 1965-92. Sixty-eight per cent of tumours were in patients over 10 years, whereas the incidence in patients under 10 years showed a non-significant increase. Survival rates increased dramatically post-chemotherapy introduction, with Ewing sarcoma demonstrating better survival overall. This is a large study giving an overview of malignant bone tumours in the childhood population of a single region over an extended period, showing results consistent with national reports. It also examines late effects, which were mostly mobility/orthopaedic, although almost one-fifth of patients had cardiac problems and five went on to develop second malignancies.


Subject(s)
Bone Neoplasms/therapy , Sarcoma, Ewing/therapy , Adolescent , Bone Neoplasms/epidemiology , Child , Child, Preschool , Female , Humans , Incidence , Infant , Male , Proportional Hazards Models , Sarcoma, Ewing/epidemiology , Survival Rate , Treatment Outcome , United Kingdom
2.
Eur J Cancer ; 43(9): 1422-9, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17499987

ABSTRACT

Altogether 156 children treated for Wilms' tumour (WT) between 1970 and 1998 were studied. Sixty-six children, selected only by their attendance at clinic, were carefully examined and the findings compared to those from a case note review of 90 children. Congenital abnormalities were present in 45% of the examined cohort, in 19% of the case notes review group and in 30% overall. Novel findings included the association of WT with Marshall Smith syndrome, developmental delay in 3 of 4 cases of WT (one bilateral) and 1 sibling from consanguineous Pakistani families and another sibling also had leukaemia. The possibility of rare DNA repair or cancer predisposing disorders among these 4 families requires further study. Careful examination and history taking of an unselected patient cohort revealed a higher than expected incidence of clinical abnormalities which may be overlooked if not specifically sought.


Subject(s)
Congenital Abnormalities/genetics , Kidney Neoplasms/complications , Wilms Tumor/complications , Adolescent , Adult , Child , Child, Preschool , Cohort Studies , Female , Follow-Up Studies , Genetic Techniques , Humans , Infant , Kidney Neoplasms/genetics , Male , Pedigree , Wilms Tumor/genetics
3.
Eur J Cancer ; 42(4): 501-8, 2006 Mar.
Article in English | MEDLINE | ID: mdl-16406574

ABSTRACT

Many survivors of childhood cancer have significant health problems due to their illness or treatment. This population-based study examines the number of long-term survivors, their disabilities and consequent long-term care needs. Survival rates for children diagnosed with cancer between 1960 and 1999 in the West Midlands, United Kingdom (UK), were used to estimate future long-term survivor numbers. Treatment and late effects data on a cohort of patients surviving for more than 5 years were used to consider continuing care needs. Between the 1960s and 1990s, 5-year survival increased from 23% to 70%. There were 98 5-year survivors in 1970, and numbers may exceed 2,100 by the end of 2005. Most (at least 61%) survivors in the West Midlands Region have one or more chronic medical problems and may require multidisciplinary care. We conclude that, in order to determine how to provide cost-effective care for this increasing population, protocol delivered management with audit is needed.


Subject(s)
Child Health Services/organization & administration , Health Status , Neoplasms/mortality , Survivors/statistics & numerical data , Adolescent , Child , Child, Preschool , England/epidemiology , Follow-Up Studies , Humans , Infant , Infant, Newborn , Long-Term Care , Neoplasms/therapy , Survival Analysis
5.
Br J Cancer ; 85(3): 350-6, 2001 Aug 03.
Article in English | MEDLINE | ID: mdl-11487264

ABSTRACT

In order to further define the factors associated with the observed variations in the Epstein-Barr virus-positive rate in childhood Hodgkin's disease, we have studied the effect of material deprivation (measured by the Townsend score) and ethnic origin on the frequency of Epstein-Barr virus-positivity in 55 cases of childhood Hodgkin's disease, diagnosed between 1981 and 1999, from a multi-ethnic region of the United Kingdom. Epstein-Barr virus status was determined by immunohistochemistry for the Epstein-Barr virus-encoded latent membrane protein-1. 62% of cases were Epstein-Barr virus-positive. Ethnic group was the strongest predictor of Epstein-Barr virus-positivity, with South Asians having a more than 20-fold risk of being Epstein-Barr virus-positive compared with non-South Asians. An increased risk was still present after adjusting for deprivation. Townsend scores were significantly higher (indicating more deprivation) in the Epstein-Barr virus-positive group, particularly in males. The relative risk of Epstein-Barr virus-positivity showed a gradient with increasing Townsend score; the risk being 7-times higher in the most deprived quartile compared with the least deprived group. Although the association between Townsend score and Epstein-Barr virus-positivity was reduced after adjusting for ethnic group, the risk of Epstein-Barr virus-positivity was still 3-times higher in the most deprived compared with the least deprived quartile. In addition, cases having 2 or more siblings were 5-times as likely to be Epstein-Barr virus-positive as those from smaller families. These results provide the first evidence of a strong association between Epstein-Barr virus-positive Hodgkin's disease and South Asian children from the United Kingdom. In addition, deprivation may increase the likelihood of Epstein-Barr virus-positive disease independently of ethnicity.


Subject(s)
Economics , Epstein-Barr Virus Infections/ethnology , Hodgkin Disease/ethnology , Adolescent , Adult , Antigens, Viral/immunology , Asia/epidemiology , Child , Child, Preschool , Epstein-Barr Virus Infections/virology , Female , Hodgkin Disease/virology , Humans , Immunohistochemistry , In Situ Hybridization , Incidence , Infant , Infant, Newborn , Male , Middle Aged , Risk Factors , Viral Matrix Proteins/immunology
6.
Br J Cancer ; 82(9): 1568-70, 2000 May.
Article in English | MEDLINE | ID: mdl-10789726

ABSTRACT

Some studies suggest that Asian children with leukaemia have a worse outcome than Whites. Survival of Asians with ALL treated at the Birmingham Children's Hospital from 1975 to 1994 was the same as that of Whites, despite their greater deprivation and poorer nutrition. For one 5-year period (1980-1984) Asians had significantly poorer survival, even after adjustment for prognostic factors. Poor treatment compliance during that period may have contributed to this difference.


Subject(s)
Precursor Cell Lymphoblastic Leukemia-Lymphoma/ethnology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/mortality , Survival Analysis , White People , Asia/ethnology , Child , Humans , United Kingdom
8.
Pediatr Hematol Oncol ; 16(1): 3-7, 1999.
Article in English | MEDLINE | ID: mdl-9932268

ABSTRACT

The hematology and oncology service at Birmingham Children's Hospital was established in the late 1960s and now is one of the largest in the United Kingdom. It provides comprehensive care for the entire range of childhood malignancies, coagulation disorders, and hemoglobinopathies and other hematological disorders, and undertakes bone marrow transplant and megatherapy/peripheral blood stem cell procedures. Research includes clinical trials of treatments of childhood cancers; molecular biology studies on leukemia, Hodgkin's disease, neuroblastoma, and sarconas; childhood cancer epidemiology, and geographical and racial incidence; and treatment of hemophilia and molecular investigation of coagulation disorders. These activities involve collaboration with local, national, and international research groups.


Subject(s)
Hematologic Diseases/therapy , Hematology , Hospitals, Pediatric , Medical Oncology , Neoplasms/therapy , Child , England , Female , Humans , Pregnancy , Prenatal Diagnosis
9.
Pediatr Hematol Oncol ; 15(6): 545-51, 1998.
Article in English | MEDLINE | ID: mdl-9842649

ABSTRACT

Paraganglioma (extra-adrenal pheochromocytoma) is a rare tumor, particularly in childhood. Those in the female genital tract are exceptionally rare, with only 9 cases reported in detail since 1926. All were seen in adults and only two arose in the vagina. This study examined the incidence of this tumor in the childhood population of the West Midlands region of the United Kingdom since 1957 and found 4 cases: 2 abdominal, 1 para-aortic, and 1 carotid body. A recent additional case is reported in the vagina of a child aged 11 years, who presented with heavy vaginal bleeding in the absence of hypertension. Initial diagnosis suggested rhabdomyosarcoma and near complete excision was carried out. Since this is the first such case to be described in a child, the outcome can only be assumed. Although histopathological examination suggested the benign nature of the tumor, implying that surgical excision was sufficient treatment, close follow-up is recommended.


Subject(s)
Paraganglioma , Vaginal Neoplasms , Adolescent , Adult , Child , Child, Preschool , Diagnosis, Differential , Female , Humans , Paraganglioma/diagnosis , Paraganglioma/pathology , Paraganglioma/physiopathology , Paraganglioma/surgery , Rhabdomyosarcoma/diagnosis , Vaginal Neoplasms/diagnosis , Vaginal Neoplasms/pathology , Vaginal Neoplasms/physiopathology , Vaginal Neoplasms/surgery
10.
IMA J Math Appl Med Biol ; 15(3): 279-97, 1998 Sep.
Article in English | MEDLINE | ID: mdl-9773520

ABSTRACT

The incidences of human diseases vary from place to place, and this is also likely to be so for the risk of people developing many of them. We have analysed the spatial distribution of childhood cancer in the West Midland Health Authority Region of England from 1980 to 1984. This is a rare disease which is considered to be noncontagious. The observed frequencies of the disease in the electoral wards have been converted to proportions that estimate the risk of a child's developing it. The spatial autocorrelation of the risk, expressed in the variogram, was determined in a novel way from the proportions within electoral wards by treating them as binomial variables dependent on the risk and the numbers of children in the wards. The observed variogram was modelled by Whittle's elementary two-dimensional correlation. Covariances of the proportion and cross covariances between the proportion and the risk were derived, and from the latter and the proportions the risk was estimated in two ways by a form of cokriging: ordinary and conditional unbiased cokriging. The variogram of the risk shows strong autocorrelation, and the kriged estimates, when mapped, have a distribution that is far from even. There are patches where the estimated risk is large, especially in the rural south west and the suburban north east; and there are other patches, notably the more densely populated areas, where it is small.


Subject(s)
Neoplasms/epidemiology , Adolescent , Binomial Distribution , Child , Child, Preschool , Data Collection , England/epidemiology , Forecasting , Humans , Models, Statistical , Population Density , Prevalence , Risk Factors
11.
Pediatr Pathol Lab Med ; 17(6): 893-902, 1997.
Article in English | MEDLINE | ID: mdl-9353829

ABSTRACT

We have performed DNA analysis by means of fluorescence-activated cell cytometry on paraffin-embedded tissue from the diagnostic biopsy specimens in 40 cases of non-Hodgkin's lymphoma (NHL) and 25 of Hodgkin's disease (HD) and from 50 normal tonsils as controls. For HD cases, aneuploidy was found in 7 of 25 (28%), a higher proportion than in two previous studies of mainly adult patients. Diploid tumors showed S-phase fractions (SPFs) similar to those of controls. In the NHL cases aneuploidy was found in 12 of 40 (30%) with no significant association with site, stage, histopathology, immunophenotype, or prognosis. SPFs were highest in abdominal and chest primary sites but were not related to stage. Burkitt's lymphomas had the highest SPFs relative to lymphoblastic (P < .01) and centroblastic lymphomas (P < .05). Significantly higher SPFs were found in B cell than in T cell tumors (P < .001). There was considerable heterogeneity for SPFs within each NHL subgroup. Survival was worse at 5 years for those with high SPFs compared with those with normal SPFs (P = .04). These results suggest that tumor DNA analysis may be useful in the evaluation of children with NHL. Larger studies are needed to define its role as an independent prognostic variable.


Subject(s)
DNA, Neoplasm/analysis , Hodgkin Disease/pathology , Lymphoma, Non-Hodgkin/pathology , Ploidies , Aneuploidy , Cell Division , Child , Flow Cytometry , Hodgkin Disease/genetics , Humans , Immunophenotyping , Lymphoma, Non-Hodgkin/genetics
12.
Br J Cancer ; 75(8): 1156-9, 1997.
Article in English | MEDLINE | ID: mdl-9099964

ABSTRACT

A retrospective histopathological review of 2104 cases of solid tumour was carried out to assess the variability in diagnosis of childhood cancer. Cases were subject to three independent, concurrent opinions from a national panel of specialist pathologists. The conformity between them was analysed using the percentage of agreement and the kappa statistic (kappa), a measure of the level of agreement beyond that which could occur by chance alone, and weighted kappa (w kappa), which demonstrates the degree of variation between opinions. The major groupings of the Birch-Marsden classification were used within which tumours were assigned for kappa analysis according to the clinical significance of the differential diagnoses. The mean agreement for all tumours together was 90%; kappa = 0.82, w kappa = 0.82. Retinoblastoma achieved the highest kappa value (1.0) and lymphoma the lowest (0.66). Of the cases, 16.5% had their original diagnoses amended and the panel confirmed the original diagnosis of paediatric pathologists in 89% of cases compared with 78% for general pathologists. The varying levels of agreement between experts confirm the difficulty of diagnosis in some tumour types, suggesting justification for specialist review in most diagnoses. Specialist training in paediatric pathology is also recommended.


Subject(s)
Medicine , Neoplasms/diagnosis , Pathology, Surgical , Specialization , Child , Humans , Reproducibility of Results , Retrospective Studies
13.
Childs Nerv Syst ; 12(10): 582-8; discussion 589, 1996 Oct.
Article in English | MEDLINE | ID: mdl-8934017

ABSTRACT

We review our experience of meningeal tumours in patients under 16 years who were treated between 1957 and 1993. These were 16 with meningiomas (median age 12 years) and 5 with poorly differentiated malignant meningeal tumours (median age 3 years). The incidence of meningeal tumours in this period was 1.62% of all CNS tumours. There were 19 supratentorial tumours (5 intraventricular), 1 tentorial and 1 cervical. Surgical excision was complete in 12 patients and incomplete in 6; in 2 patients a biopsy only was undertaken. The remaining patient had radiological diagnosis only. All 5 patients in the group with malignant poorly differentiated tumours died (median survival 5 months), confirming the aggressive nature of these lesions. Of the 16 patients with meningiomas, 4 died during followup but 11 of the 12 meningioma patients remaining alive had complete resections. There is a strong tendency for paediatric meningeal tumours to have a supratentorial origin and intraventricular location. The female preponderance found in adults is not evident in children. Incomplete surgical excision or focal neurological deficit at presentation was associated with poor outcome.


Subject(s)
Meningeal Neoplasms/diagnosis , Meninges/pathology , Meningioma/diagnosis , Adolescent , Child , Child, Preschool , Female , Humans , Magnetic Resonance Imaging , Male , Meningeal Neoplasms/pathology , Meningeal Neoplasms/surgery , Meninges/surgery , Meningioma/pathology , Meningioma/surgery , Retrospective Studies , Survival Rate , Tomography, X-Ray Computed
14.
Cancer ; 78(4): 858-63, 1996 Aug 15.
Article in English | MEDLINE | ID: mdl-8756382

ABSTRACT

BACKGROUND: Trilateral retinoblastoma is a well recognized, although rare, syndrome. Most of the reported cases have involved a family history of retinoblastoma (RB) and the disease is almost always fatal. The authors chose to investigate the cases of trilateral retinoblastoma occurring in the West Midlands, a region of the United Kingdom with an increasing incidence of bilateral sporadic RB. METHODS: Five patients with trilateral retinoblastoma (including two were previously reported), diagnosed in 146 consecutive patients with RB in the West Midlands Health Authority Region between 1957 and 1994, are presented (an incidence of 3%). Their clinical presentation, treatment, and outcome are described. RESULTS: There were 4 patients with pineoblastoma, only one of whom had a positive family history. The mean age at diagnosis of RB and 6 months, whereas the patients with pineoblastoma were diagnosed at a mean age of 2 years 8 months. The tumors were not evident on the initial computed tomography scans. One child presented with a calcified suprasellar mass 13 months before the bilateral sporadic RB was identified. Death occurred within 1 month of diagnosis of the intracranial tumor in 3 patients who did not receive any treatment. In the other 2 patients who were treated, death occurred at 15 months and 2 years 7 months, respectively, after diagnosis of intracranial tumor. CONCLUSIONS: Early diagnosis with regular neuro-imaging and more aggressive treatment may improve prognosis in patients with RB and an intracranial tumor.


Subject(s)
Eye Neoplasms , Retinoblastoma , Child , Child, Preschool , Eye Neoplasms/pathology , Eye Neoplasms/therapy , Female , Humans , Infant , Infant, Newborn , Male , Retinoblastoma/pathology , Retinoblastoma/therapy , Treatment Outcome
16.
Br J Cancer ; 72(6): 1563-9, 1995 Dec.
Article in English | MEDLINE | ID: mdl-8519679

ABSTRACT

Cancer and associated congenital abnormalities were investigated in Muslim and non-Muslim Asian children from the West Midlands. Cancer incidence rates were calculated for Indian (non-Muslim), Pakistani/Bangladeshi (Muslim) and white children diagnosed from 1978 to 1992. Incidence was significantly higher in the Pakistanis, with an age-standardised rate (ASR) of 163 cases per million per year, compared with 115 for Indian and 125 for white children. Among Asian cancer patients, congenital malformations were significantly more common in Muslim (21%) compared with non-Muslim (7%). In Muslims the malformation excess was caused by autosomal recessive and dominant disorders (in 8% and 5% of cases respectively). Cancer malformation/predisposition syndromes were found in 10% of Muslims, compared with 2% of non-Muslims. In 33% of the Muslims with malformations, childhood cancer and a malformation were also present in a close relative. None of the non-Muslims with malformations had a relative with childhood cancer. The cancer excess in Muslims may be partly related to inherited genes causing both malformations and cancer. The prevalence of autosomal recessive disorders may be related to consanguinity, which is common in the Pakistani Muslim population. The high incidence of autosomal dominant disorders may be related to older paternal age at conception, giving rise to spontaneous mutations.


Subject(s)
Congenital Abnormalities/epidemiology , Neoplasms/epidemiology , Adolescent , Age Factors , Bangladesh/ethnology , Child , Child, Preschool , England/epidemiology , Family Health , Female , Humans , Incidence , India/ethnology , Infant , Islam , Male , Pakistan/ethnology , White People
17.
Br J Cancer ; 72(1): 219-23, 1995 Jul.
Article in English | MEDLINE | ID: mdl-7599055

ABSTRACT

The West Midlands Regional Children's Tumour Research Group holds high-quality data from 1957 on all childhood cancers in the West Midlands Health Authority region. Since it has been reported that malignant germ cell tumours are increasing in incidence in the north-west of England, we undertook to examine rates in this region and to map the distribution of cases in order to assess any geographical changes in incidence rates. We identified a total of 102 malignant germ cell tumours (MGCTs) between 1957 and 1992. The average age-standardised rate was 1.6 per million per year in the period 1957-74 and 3.6 per million per year during 1975-92, a significant increase (P = 0.0004). Particular increases were noted in older children (10-14 years); P = 0.0002) and in yolk sac (endodermal sinus) tumours (P = 0.004). A small excess was also observed in Asian children when compared with other diagnoses. Geographical analysis showed particularly higher rates at health district level in the West Midlands conurbation as compared with the other areas in the period 1975-92. These factors suggest the possibility that industrial/urban or population effects may be implicated in the observed increase in childhood MGCT and we recommend these areas for further studies.


Subject(s)
Germinoma/epidemiology , Adolescent , Age Factors , Child , Child, Preschool , Female , Germinoma/ethnology , Humans , Incidence , Infant , Infant, Newborn , Male , Registries , Sex Distribution , Time Factors , United Kingdom/epidemiology
18.
Cancer ; 76(1): 155-6, 1995 Jul 01.
Article in English | MEDLINE | ID: mdl-8630871
19.
J Clin Pathol ; 48(1): 22-5, 1995 Jan.
Article in English | MEDLINE | ID: mdl-7535803

ABSTRACT

AIMS: To analyse the immunophenotype of a large number of non-endemic Burkitt's lymphomas to determine whether a B cell phenotype is consistently recognisable using formalin fixed, paraffin wax embedded archival material and a standard panel of commercially available antibodies. METHODS: Archival material was obtained from 30 cases of childhood Burkitt's lymphoma registered with the West Midlands Regional Children's Tumour Research Group. These were analysed by a standard avidin biotin complex immunoperoxidase method using antibodies to CD45, CD43, CD30, CD20, CD15, and immunoglobulin heavy and light chains. RESULTS: There was a high incidence of the CD45RB and CD20 immunophenotypes, with a clearly recognisable B cell lineage even in archival material. IgM was identifiable in 13 of the 23 (56.5%) cases tested. Only three of 17 (18%) cases expressed CD30. Positive membrane staining with CD45RO was observed in two (6.7%) cases. CONCLUSIONS: A B cell lineage can be identified in Burkitt's lymphoma in formalin fixed, paraffin wax embedded material, even in archival tissue. There was a low incidence of membrane staining with CD45RO which is a potential source of diagnostic confusion.


Subject(s)
B-Lymphocytes/immunology , Burkitt Lymphoma/immunology , Immunophenotyping , Neoplastic Stem Cells/immunology , Adolescent , Antigens, CD/analysis , Antigens, CD20 , Antigens, Differentiation, B-Lymphocyte/analysis , Antigens, Neoplasm/analysis , B-Lymphocytes/pathology , Child , Child, Preschool , Female , Humans , Immunoenzyme Techniques , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Leukocyte Common Antigens/analysis , Male , Neoplastic Stem Cells/pathology
20.
Arch Dis Child ; 71(5): 398-403, 1994 Nov.
Article in English | MEDLINE | ID: mdl-7826109

ABSTRACT

The pattern of cancer in white and Asian (Indian, Pakistani, and Bangladeshi) children living in the West Midlands Health Authority Region was investigated using age standardised incidence rates. Two sets of rates were calculated, a 10 year rate (1982-91) using survey based estimates of the ethnic population and a four year rate (1989-92) using the ethnic population counts from the 1991 census. The 10 year rates showed a significantly higher annual incidence of cancer in Asian (159.1/million/year) than in white (130.8) children. The pattern of cancers in Asian children was different, with an excess of lymphomas and germ cell tumours, and a deficit of rhabdomyosarcomas. These findings were confirmed by the four year rates. Although underestimation of the Asian population probably contributes to the apparent excess, there remains cause for concern that UK Asian children may be at higher risk of cancer. Accurate ethnic population figures and confirmatory studies are urgently required.


Subject(s)
Neoplasms/ethnology , Adolescent , Bangladesh/ethnology , Central Nervous System Neoplasms/ethnology , Child , Child, Preschool , England/epidemiology , Humans , Incidence , India/ethnology , Infant , Infant, Newborn , Leukemia/ethnology , Lymphoma/ethnology , Neoplasms, Germ Cell and Embryonal/ethnology , Pakistan/ethnology , Registries , Risk Factors , Sarcoma/ethnology
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