Guest-responsive coherence time of radical qubits in a metal-organic framework.

Metal-organic frameworks (MOFs) integrated with molecular qubits are promising for quantum sensing. In this study, a new UiO-type MOF with a 5,12-diazatetracene (DAT)-containing ligand is synthesized, and the radicals generated in the MOF exhibit high stability and a relatively long coherence time (T2) responsive to the introduction of various guest molecules.

Radical qubits photo-generated in acene-based metal-organic frameworks.

A series of metal-organic frameworks (MOFs) assembled with diazatetracene (DAT)-based linkers were synthesized and characterized. Despite different chromophore orientations and spacings, photoinduced persistent radicals were generated in all the MOFs, and their spin-lattice relaxation time (T1) and spin-spin relaxation time (T2) were found to be relatively long even at room temperature. The generality of long T1 and T2 values of photogenerated radicals in the chromophore-assembled MOFs provides a new platform towards quantum sensing applications.

azyx-1 is a new gene that overlaps with zyxin and affects its translation in C. elegans, impacting muscular integrity and locomotion.

Overlapping genes are widely prevalent; however, their expression and consequences are poorly understood. Here, we describe and functionally characterize a novel zyx-1 overlapping gene, azyx-1, with distinct regulatory functions in Caenorhabditis elegans. We observed conservation of alternative open reading frames (ORFs) overlapping the 5' region of zyxin family members in several animal species, and find shared sites of azyx-1 and zyxin proteoform expression in C. elegans. In line with a standard ribosome scanning model, our results support cis regulation of zyx-1 long isoform(s) by upstream initiating azyx-1a. Moreover, we report on a rare observation of trans regulation of zyx-1 by azyx-1, with evidence of increased ZYX-1 upon azyx-1 overexpression. Our results suggest a dual role for azyx-1 in influencing zyx-1 proteoform heterogeneity and highlight its impact on C. elegans muscular integrity and locomotion.

Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome.

Nitro-fatty acids (NFAs) are endogenous lipid mediators causing a spectrum of anti-inflammatory effects by covalent modification of key proteins within inflammatory signaling pathways. Recent animal models of solid tumors have helped demonstrate their potential as anti-tumorigenic therapeutics. This study evaluated the anti-tumorigenic effects of NFAs in colon carcinoma cells and other solid and leukemic tumor cell lines. NFAs inhibited the ubiquitin-proteasome system (UPS) by directly targeting the 26S proteasome, leading to polyubiquitination and inhibition of the proteasome activities. UPS suppression induced the unfolded protein response, resulting in tumor cell death. The NFA-mediated effects were substantial, specific, and enduring, representing a unique mode of action for UPS suppression. This study provides mechanistic insights into the biological actions of NFAs as possible endogenous tumor-suppressive factors, indicating that NFAs might be key structures for designing a novel class of direct proteasome inhibitors.

SpinTip: A Simple, Robust, and Versatile Preanalytical Method for Microscale Suspension Cell Proteomics.

Sample loss and contamination are critical preanalytical pitfalls in microscale proteomic applications of nonadhering cells. Common assays and workflows are not easily adoptable to microscale sample sizes of suspension cells due to inadvertent sample loss. This impedes preanalytical experimental manipulation of limited suspension cell samples for microscale proteomics applications, such as encountered for primary human materials. Here, we describe and test a simple manual batch technique for single-step 100-fold concentration of scarce numbers of diluted suspension cells (down to 5000 cells) by volume reduction, facilitating microscale experiments with suspension cells. Pipette tips with heat-sealed orifices (SpinTips) are manufactured within 1 min and serve as versatile microcentrifugation vessels from which supernatant can be aspirated with minimal cell loss. A residual volume of approximately 3 µL can be achieved without visualization of the cell pellet. The results show that SpinTips enable the concentration, medium exchange, washing, and culture of highly limited amounts of suspension cells for functional manipulation and microscale proteomics and are readily incorporated into standard workflows. The application is illustrated by profiling ex vivo responses of primary acute myeloid leukemia (AML) cells from one AML patient to daunorubicin (DNR) to a depth of 3462 quantified proteins with excellent repeatability.

Assistive device using computer vision and image processing for visually impaired; review and current status.

PURPOSE: The purpose of this article is to review the vision substitution devices based on computer vision and Image processing. The focus of this article is on reviewing devices that require coding and sensors mechanism. METHODS: Review of existing and commercially available vision assistive devices has been done. Comparison is based on feedback mechanics, adaptability in the surrounding environment, and functionality of devices. The study extended to advanced researches based on computer science and image processing. The integration of object detection and face recognition techniques in assistive devices for visually impaired in specific applications has been studied. Comparative analyses were presented. RESULTS: The findings from this study suggest that a few assistive devices are available commercially. The commercially available assistive devices influenced by the mindsets of visually impaired and economical benefits. A combination of several devices can be fruitful in eliminating the limitation of an available device. Ample researches have been done for navigation, communication, object detection, and object recognition to assist visual impaired. The primary results might be promising, but most studies are not tested in actual conditions. CONCLUSION: Various assistive devices for visually impaired are available commercially and several studies indicate further advancement. However, adaptability and trustworthiness are major issues. The primary reason behind this is the low-performance level of the device, feedback, and testing. The secondary reason is commercial availability and poor knowledge of the end-user.IMPLICATIONS FOR REHABILITATIONAdvancement in computer science and image processing has paved the way to assist sensory impaired in doing various activities.Assistive technologies play a pivotal role in daily activities of visually impaired by assisting them for communication, and mobility.Assistive technologies can lead visually impaired to make them self-sustained.Very few research and devices related to assistive technology had reached the stage of testing and commercialization.Researchers can utilize the study in providing better assistive technology for the visually impaired.

Identification of Non-Canonical Translation Products in C. elegans Using Tandem Mass Spectrometry.

Transcriptome and ribosome sequencing have revealed the existence of many non-canonical transcripts, mainly containing splice variants, ncRNA, sORFs and altORFs. However, identification and characterization of products that may be translated out of these remains a challenge. Addressing this, we here report on 552 non-canonical proteins and splice variants in the model organism C. elegans using tandem mass spectrometry. Aided by sequencing-based prediction, we generated a custom proteome database tailored to search for non-canonical translation products of C. elegans. Using this database, we mined available mass spectrometric resources of C. elegans, from which 51 novel, non-canonical proteins could be identified. Furthermore, we utilized diverse proteomic and peptidomic strategies to detect 40 novel non-canonical proteins in C. elegans by LC-TIMS-MS/MS, of which 6 were common with our meta-analysis of existing resources. Together, this permits us to provide a resource with detailed annotation of 467 splice variants and 85 novel proteins mapped onto UTRs, non-coding regions and alternative open reading frames of the C. elegans genome.

Zn(II)/Cd(II)-Based Metal-Organic Frameworks as Bifunctional Materials for Dye Scavenging and Catalysis of Fructose/Glucose to 5-Hydroxymethylfurfural.

Functional neutral metal-organic frameworks (MOFs) {[M(5OH-IP)(L)]}n [M = Zn(II) for ADES-4; Cd(II) for ADES-5; 5OH-IP = 5-hydroxyisophthalate; L = (E)-N'-(pyridin-3-ylmethylene)nicotinohydrazide) have been synthesized by a diffusion/conventional reflux/mechanochemical method and characterized by various analytical techniques. Crystals were harvested by a diffusion method, and single-crystal X-ray diffraction (SXRD) analysis revealed that an adjacent [M2(COO)2]n ladder chain generates isostructural two-dimensional network motifs by doubly pillaring via L. The bulk-phase purity of ADES-4 and ADES-5 synthesized by a versatile synthetic approach has been recognized by the decent match of powder X-ray diffraction patterns with the simulated one. Both ADES-4 and ADES-5 showed selective adsorption of cationic dyes methylene blue (MB), methyl violet (MV), and rhodamine B (RhB) over anionic dye methyl orange (MO) from water with good uptake and rapid adsorption. Utilization of ADES-4 as a chromatographic column filler for adsorptive removal of individual cationic dyes as well as a mixture of dyes has been demonstrated from the aqueous phase. Interestingly, ADES-4 is reusable with good stability, and it showed a dye desorption phenomenon in methanol. The probable mechanism of cationic dye removal based on insight from structural information and plausible supramolecular interactions has also been explored. Both MOFs also showed efficient catalytic transformation of fructose and glucose into the high-value chemical intermediate 5-hydroxymethylfurfural of industrial significance.

Recent advances in metal-organic frameworks as adsorbent materials for hazardous dye molecules.

Water is vital for the sustenance of all forms of life. Hence, water pollution is a universal crisis for the survival for all forms of life and a hurdle in sustainable development. Textile industry is one of the anthropogenic activities that severely pollutes water bodies. Inefficient dyeing processes result in thousands of tons of synthetic dyes being dumped in water bodies every year. Therefore, the efficient removal of synthetic dyes from wastewater has become a challenging research field. Owing to their tuneable structure-property aspects, metal-organic frameworks (MOFs) have emerged as promising adsorbents for the adsorptive removal of dyes from wastewater and textile effluents. In this perspective, we highlight recent studies involving the application of MOFs for the adsorptive removal of hazardous dye molecules. We also classify the developed MOFs into cationic, anionic, and neutral framework categories to comprehend their suitability for the removal of a given class of dyes.

Ring-opening hydrolysis of spiro-epoxyoxindoles using a reusable sulfonic acid functionalized nitrogen rich carbon catalyst.

Controlling the product selectivity of a ring-opening hydrolysis reaction remains a great challenge with mineral acids and to an extent with homogeneous catalysts. In addition, even trace amounts of metal impurities in a bioactive product hinder the reaction progress. This has necessitated the development of robust and metal-free catalysts to offer an alternative sustainable route. We report a nitrogen-rich sulfonated carbon as a catalyst derived from an inexpensive precursor for the synthesis of bioactive vicinal diols of spiro-oxindole derivatives. The well-characterized catalyst shows wide generality with different electronic and steric substituents in the substrates under mild reaction conditions. Hot filtration test confirms no leaching of the acid moiety and the catalyst could be reused for four cycles with retention of activities.

Controlled assembly of cobalt embedded N-doped graphene nanosheets (Co@NGr) by pyrolysis of a mixed ligand Co(ii) MOF as a sacrificial template for high-performance electrocatalysts.

The development of high-efficiency and durable bifunctional electrocatalysts is an important and challenging topic in the area of energy storage/conversion. Herein, we prepared metallic cobalt nanoparticle decorated N-doped graphitic sheets (Co@NGr) by adopting facile pyrolysis of a mixed ligand cobalt-based MOF (CoMOF-2) as a sacrificial template displaying good OER and HER activity. The catalytic material harvested at three different pyrolytic temperatures was characterized by various analytical methods such as PXRD, SEM, TEM, Raman, and XPS analyses. The catalytic activity of the obtained hybrid composite materials towards oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) was studied. Co@NGr-900 was found to be an efficient bifunctional electrocatalyst and 10 mA cm-2 current density was afforded at an overpotential of 390 mV for OER and 340 mV for HER respectively. This study provides insight for the development of cost-effective nonprecious element-based electrocatalysts for water splitting which has relevance in energy storage and conversion. Catalytic performance is governed by the synergistic compositional effect of metallic cobalt/nitrogen-doping in the graphitic carbon increasing the electrical conductivity/active sites of the composite material.

Cycloaddition of CO2 with an Epoxide-Bearing Oxindole Scaffold by a Metal-Organic Framework-Based Heterogeneous Catalyst under Ambient Conditions.

The synthesis and characterization of a mixed ligand metal-organic framework (MOF) with good thermal and chemical stability, {[Co(BDC)(L)·2H2O]·xG}n (CoMOF-2), involving an aromatic dicarboxylate (H2BDC = 1,4-benzenedicarboxylic acid) and an acyl-decorated N-donor linker [L = (E)-N'-(pyridin-4-ylmethylene) isonicotinohydrazide] by various physicochemical techniques, including Single crystal X-Ray Diffraction (SXRD), are reported. The MOF showed a good affinity for CO2 capture, and Grand Canonical Monte Carlo simulation studies exposed strong interactions of CO2 with the functionalized N-donor ligand of the framework. CoMOF-2 and KI act as an efficient binary catalyst for the sustainable utilization of CO2 with spiro-epoxy oxindole to spirocyclic carbonate under ambient conditions. Notably, herein we report MOF-based catalysis for the cycloaddition of oxindole-based epoxides with CO2 for harvesting new spirocyclic carbonates. Interestingly, we could isolate and crystallize six of the spirocyclic carbonate products, and the structure of the newly synthesized molecules has been established by SXRD analysis. We present a plausible proposed catalytic mechanism through activation of the epoxide ring by the Lewis acidic/basic sites present on the framework surface that is validated by molecular modeling.

Exploring neuropeptide signalling through proteomics and peptidomics.

INTRODUCTION: Neuropeptides are neuro-endocrine signaling molecules capable of signaling as neurotransmitters, neuromodulators or neurohormones. Studying how neuropeptide signaling is integrated in endocrine pathways and how neuropeptides regulate endogenous processes is crucial to understanding how multicellular organisms respond to environmental and internal cues. Areas covered: This review will cover proteomics and peptidomics approaches used in researching peptide signaling systems and breakthroughs that were achieved in this field. Both differential mass spectrometry and reverse genetic approaches are commonly used to study neuropeptidergic signaling. The field of proteomics quickly developed in the past decades and expanded from gel-based approaches to include advanced liquid chromatography and mass spectrometry. We explore how proteomics is used to reveal neuropeptide maturation and identify downstream targets of neuropeptide signaling pathways. We show how peptidomics differs from standard proteomics approaches and how it is used to study both neuropeptide processing and signal pathway identification. Expert commentary: Thanks to recent advancements in isolation techniques and increased sensitivity of equipment, proteomics and peptidomics studies of neuropeptide signaling are contributing increasingly to elucidating functional implications of endocrine signaling. Further technical progress should allow for full peptidomic profiling of single neurons, eventually providing us with a complete comprehension of endocrine signaling.

Sustainable Heterogeneous Catalysts for CO2 Utilization by Using Dual Ligand ZnII /CdII Metal-Organic Frameworks.

Two-dimensional ZnII /CdII -based dual ligand metal-organic frameworks (MOFs) {[M(CHDC)(L)]⋅H2 O}n involving 4-pyridyl carboxaldehyde isonicotinoylhydrazone (L) in combination with flexible 1,4-cyclohexanedicarboxylic acid (H2 CHDC) as linkers have been synthesized by adaptable synthetic protocols including a green mechanochemical (grinding) method. Characterization, chemical/thermal stability, phase purity, and solid-state luminescent properties of both MOFs have been established by various analytical methods. Structural analysis revealed dimeric metal clusters composed of [M2 (CHDC)2 ]n loops doubly pillared with L, generating a 2D framework. Both MOFs can be used as highly active solvent-free binary catalysts for CO2 cycloaddition with epoxides in the presence of the co-catalyst tetrabutylammonium bromide (TBAB) with good catalytic conversion in up to six catalytic cycles without significant loss of activity. The present investigation demonstrates the application of MOFs as efficient heterogeneous catalysts for CO2 utilization under moderate reaction conditions. Based on the single-crystal X-ray data, a probable mechanism for the cycloaddition reaction has also been proposed.

Amine-functionalized Zn(ii) MOF as an efficient multifunctional catalyst for CO2 utilization and sulfoxidation reaction.

Herein, a zinc(ii)-based 3D mixed ligand metal organic framework (MOF) was synthesized via versatile routes including green mechanochemical synthesis. The MOF {[Zn(ATA)(L)·H2O]}n (ZnMOF-1-NH2) has been characterized by various physico-chemical techniques, including SCXRD, and composed of the bipyridyl-based Schiff base (E)-N'-(pyridin-4-ylmethylene)isonicotinohydrazide (L) and 2-aminoterephthalic acid (H2ATA) ligands as linkers. The MOF material has been explored as a multifunctional heterogeneous catalyst for the cycloaddition of alkyl and aryl epoxides with CO2 and sulfoxidation reactions of aryl sulfides. The influence of various reaction parameters is examined to optimize the performance of the catalytic reactions. It is found that solvent-free catalytic reaction conditions offer good catalytic conversion in the case of cyclic carbonates, and for sulfoxide, good conversion and selectivity are achieved in the presence of DCM as a solvent medium under ambient reaction conditions. The chemical and thermal stability of the catalyst are excellent and it is active for up to four catalytic cycles without significant loss in activity. Furthermore, based on the catalytic activity and structural evidence, a plausible mechanism for both catalytic reactions is proposed.

Selective and reversible adsorption of cationic dyes by mixed ligand Zn(ii) coordination polymers synthesized by reactant ratio modulation.

Dye capture and separation through coordination polymers (CPs) has been a promising research field in recent times due to the toxic and nondegradable nature of organic dyes released into the environment from various industries as well as the reusability of CPs for the said purpose. Here, we report the synthesis and characterization of two mixed ligand CPs {[Zn2(HBTC)2(L)(H2O)2](C2H5OH)3}n (CP1) and {[Zn5(BTC)2(L)3(OH)4(H2O)2](H2O)4(CH3OH)11}n (CP2) (where H3BTC = 1,3,5-benzene tricarboxylic acid and L = 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene) by the stoichiometric variation of the precursors. The crystal structure analysis revealed that CP1 is a 2D network composed of a [Zn2(HBTC)2(H2O)2]n motif linked via terminal nitrogen atoms of L and CP2 is a 3D framework in which symmetrically disposed two-dimensional {[Zn5(BTC)2(L)3(OH)4(H2O)2]}n sheets composed of pentanuclear [Zn5(RCO2)6(µ3-OH)2(µ2-OH)2(H2O)2] SBUs are pillared by L ligands. Adsorption and separation of cationic dyes by CP1 and the solid-state fluorescence properties of both CPs have been investigated. Cationic dyes (RhB, MB, and MV) can be effectively adsorbed by CP1 from their aqueous solution (61%, 90%, and 97%, respectively) while the anionic dye methyl orange (MO) remains uncaptured. Dye desorption studies and CP1 as a column chromatographic filler for the separation of cationic dyes in water have also been demonstrated.

Mixed-Ligand LMOF Fluorosensors for Detection of Cr(VI) Oxyanions and Fe3+/Pd2+ Cations in Aqueous Media.

Zn(II)/Cd(II)-based dual ligand Luminescent Metal-Organic Frameworks (LMOFs) {[M(ATA)(L)]}n·xH2O (1) and (2) were synthesized by versatile synthetic routes, viz., diffusion of precursor solutions, conventional reflux, and green mechanochemical (grinding) reactions from bipyridyl-based Schiff base, (E)-N'-(pyridin-4-ylmethylene)isonicotinohydrazide (L) and amino functionalized 2-aminoterephthalic acid (H2ATA) as linkers. Chemical and thermal stability, phase purity, and characterization of both LMOFs were established by various analytical methods. SXRD analysis revealed the 3D framework is composed of two-dimensional [M(ATA)]n nets doubly pillared by L through the terminal nitrogen atom. Selective and sensitive detection of chromate anions (CrO42-/Cr2O72-) and Fe3+/Pd2+ cations in the aqueous phase by fluorescent quenching of the LMOFs 1 and 2 has been established. Competitive experiments in the presence of interfering anions/cations with 1 and 2 revealed no major change in the quenching efficiency. The observed limits of detection (LOD) values by 1 for CrO42-/Cr2O72- were 0.25 µM (48 ppb)/0.43 µM (126 ppb) and for Fe3+/Pd2+ were 3.76 µM (0.61 ppm)/0.20 µM (35 ppb), whereas LOD values by 2 were 0.18 µM (35 ppb)/0.19 µM (55 ppb) and 1.77 µM (0.29 ppm)/0.10 µM (18 ppb), respectively. Simple fluorescent-based test paper strips have been developed for reliable and visual detection of the mentioned analytes in practical applications. The present investigation clearly demonstrates selective detection of CrO42-/Cr2O72- and Fe3+/Pd2+ in aqueous media, and the probable mechanism for the quenching phenomena based on structural aspects has also been discussed.

Solvothermal self-assembly of Cd2+ coordination polymers with supramolecular networks involving N-donor ligands and aromatic dicarboxylates: synthesis, crystal structure and photoluminescence studies.

Two cadmium(ii) coordination polymers (CPs) of compositions {[Cd(H2O)4(4-BPDB)][BPDC]}n (CP1) and {[Cd(H2O)(BrIP)(BTTMB)]·4MeOH}n (CP2) have been synthesized by solvothermal methods and characterized by several analytical methods including SXRD (Single Crystal X-ray Diffraction). The structure of CP1 can be described as a 1D cationic chain, {[Cd(H2O)4(4-BPDB)]2+}n and discrete BPDC counter anions. The structure of CP2 revealed an undulated 2D sql net comprising Cd2+ nodes bridged by the ditopic N-donor, BTTMB and dicarboxylate BrIP involved in µ2-η1η1η1η1 coordination. Supramolecular interactions in both CPs generate 3D hydrogen bonded architectures. The solid state fluorescence properties of these d10 metal ion containing CPs have been investigated. Fluorescence emission of CP1 suspended in acetonitrile is observed to be selectively quenched by acetone (LOD = 0.15 mM) over other common laboratory solvents.

Mechanochemical and Conventional Synthesis of Zn(II)/Cd(II) Luminescent Coordination Polymers: Dual Sensing Probe for Selective Detection of Chromate Anions and TNP in Aqueous Phase.

Isostructural Zn(II)/Cd(II) mixed ligand coordination polymers (CPs) {[M(IPA)(L)]}n (CP1 and CP2) built from isophthalic acid (H2IPA) and 3-pyridylcarboxaldehyde nicotinoylhydrazone (L) were prepared using versatile synthetic routes: viz., diffusion of precursor solutions, conventional reflux methods, and green mechanochemical (grinding) reactions. Both robust CPs synthesized by different routes were characterized by various analytical methods, and their thermal and chemical stability as well as the phase purity was established. Crystallographic studies revealed that CP1 and CP2 are isostructural frameworks and feature a double-lined two-dimensional network composed of Zn2+/Cd2+ nodes connected through IPA and pillared by the Schiff base ligand L with a double-walled edge. The photoluminescent (PL) properties of CP1 and CP2 have been exploited as dual detection fluorosensors for hexavalent chromate anions (CrO42-/Cr2O72-) and 2,4,6-trinitrophenol (TNP) because it was observed that the emission intensity of aqueous suspensions of CPs selectively quenches by chromate anions or TNP among large pools of different anions or nitro compounds, respectively. Competitive experiments in the presence of interfering anions/other nitro compounds also revealed no major effect in the quenching efficiency, suggesting the selective detection of hexavalent chromate anions as well as TNP by the LCPs. The limits of detection by CP1 for CrO42-/Cr2O72- and TNP are 4 ppm/4 ppm and 28 ppb, respectively, whereas the limits of detection by CP2 for the same analytes are 1 ppm/1 ppm and 14 ppb, respectively. A probable mechanism for the quenching phenomena is also discussed.

Mixed ligand two dimensional Cd(ii)/Ni(ii) metal organic frameworks containing dicarboxylate and tripodal N-donor ligands: Cd(ii) MOF is an efficient luminescent sensor for detection of picric acid in aqueous media.

Two dimensional metal organic frameworks (MOFs) [Cd(5-BrIP)(TIB)]n () and [Ni2(5-BrIP)2(TIB)2]n (), involving the aromatic polycarboxylate ligand 5-bromo isophthalic acid (H2BrIP), flexible tripodal ligand 1,3,5-tris(imidazol-1-ylmethyl)benzene (TIB) and Cd(ii)/Ni(ii) metal nodes have been synthesized by different methods. These compounds were characterized by various analytical methods, and variable temperature X-ray diffraction data showed thermal stability of both MOFs up to 350 °C. Phase purity as well as water stability of the MOFs were established by powder X-ray diffraction, and the structural diversity of the compounds were investigated by single-crystal X-ray diffraction. Both the MOFs are mixed ligand 2D nets, and the topology of the network can be described as a binodal 3,5-c connected net with 3,5L2 topology having the point symbol {4(2)·6(7)·8}{4(2)·6}. Sensing of picric acid [2,4,6-trinitrophenol, TNP] by luminescence quenching among a large range of nitroanalytes in aqueous phase by the Cd(ii) luminescent MOF (LMOF) were been investigated. Structural studies on 1 : 1 co-crystals () of TIB and TNP were carried out. The selective and sensitive fluorescence quenching response of towards electron-deficient TNP over other nitro analytes in aqueous phase was demonstrated by fluorescence quenching titration. Concomitant occurrence of electron transfer/energy transfer processes and electrostatic interaction favours the selective sensing of TNP. A Cd(ii) LMOF ()-coated paper strip that we developed demonstrated fast and selective response to TNP, by the complete quenching of the blue fluorescence upon excitation of the paper strip at 365 nm radiation in its presence.